... drug-induced movement disorder dyskinesia dystonia glutamatergic pathway neurodegenerative disease Parkinson’s disease Briefly, LID has been associated both with an increased activity and with altered patterns of activity in glutamatergic pathways within the corticobasal ganglia network...

... (Lis-1) neurodegenerative disease nuclear distribution protein E (NDE1) nuclear distribution protein E-like (NDEL1) Intracellular cargo transport is driven by myosin, kinesin and dynein motor proteins that can move directionally along actin filaments and microtubules. Myosins use actin...

... to the aetiology of various neurodegenerative diseases related to protein conformational disorders by causing the accumulation of mutant proteins and cellular toxicity. Combining the knowledge of autophagy dysfunction and the mechanism of drug action may thus be rational for designing targeted therapy. The present...

... Biochemistry 1998 37 10223 10230 19 Morfini G.A. Burns M. Binder L.I. Kanaan N.M. LaPointe N. Bosco D.A. Brown R.H. Jr Brown H. Tiwari A. Hayward L. Axonal transport defects in neurodegenerative diseases J. Neurosci. 2009 29 12776 12786 20...

... Society 2008 iron chelation metal ion neurodegenerative disease oxidative stress protein aggregation therapy A classification of neurodegeneration can be achieved on the basis of the principal neuropathological changes, characterized by the presence of abnormal protein components [ 1...

... potential benefit in acute stroke patients. © The Authors Journal compilation © 2007 Biochemical Society 2007 inflammation interleukin-1 (IL-1) interleukin-1 receptor antagonist (IL-1RA) ischaemia neurodegenerative disease stroke Inflammation is generally a beneficial response...

...K.J. Krishnan; A.K. Reeve; D.M. Turnbull A decline in mitochondrial function has long been shown to exist in neurodegenerative disease. Whether this decline is a secondary consequence of other factors or whether it causes the eventual death of a cell is unknown. In this review, we will discuss some...

... pertinent pharmacological targets to induce neuroprotection in chronic neurodegenerative diseases. 1 To whom correspondence should be addressed (email [email protected] ). 11 8 2006 © 2006 The Biochemical Society 2006 cerebral ischaemia neurodegenerative disease...

... in various neurodegenerative diseases. Many proteins have the ability to produce amyloid-like structures, including the pre-synaptic protein α-syn, which is found in Lewy bodies [ 1 ]. EM (electron microscopy) has been used to show that α-syn fibrils both in brain extracts and formed in vitro are rigid...

...L. Masino; A. Pastore A growing number of neurodegenerative diseases are caused by expansion of CAG trinucleotide repeats coding for polyglutamine. The presence of intranuclear inclusions in the affected neuronal cells has suggested a mechanism for pathogenesis based on protein misfolding...

... neurodegenerative disease plasticity microglia Biochemical Society Transactions (2002) Volume 30, part 2 Tissue plasminogen activator as a modulator of neuronal survival and function S. E. Tsirka' Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY I 1794-865 I...