...Norbert Zilka; Branislav Kovacech; Peter Barath; Eva Kontsekova; Michal Novák Pathological truncations of human brain proteins represent the common feature of many neurodegenerative disorders including AD (Alzheimer's disease), Parkinson's disease and Huntington's disease. Protein truncations...

...) [ 21 ]. The phenotype associated with the 17q21.31 microduplication thus covers a broad range of disorders, including neurodevelopmental and neurodegenerative disorders. One should note that the FTLD patient only carried the H1 haplotype, whereas other patients all had H1/H2 haplotypes. The genotype...

...Robert Layfield; Mark S. Searle A role for ubiquitin in the pathogenesis of human diseases was first suggested some two decades ago, from studies that localized the protein to intracellular protein aggregates, which are a feature of the major human neurodegenerative disorders. Although several...

...M. Baron; A.P. Kudin; W.S. Kunz There is compelling evidence for the direct involvement of mitochondria in certain neurodegenerative disorders, such as Morbus Parkinson, FRDA (Friedreich's ataxia), ALS (amyotrophic lateral sclerosis), and temporal lobe epilepsy with Ammon's horn sclerosis...