... partners to regulate synaptic maturation and efficacy [ 36 , 37 ]. GABA glutamate mouse models neurodevelopmental disorders neuroimaging serotonin Autism spectrum disorders (ASD) are a heterogenous set of syndromes characterised by social impairments and communication deficits, often...

... that undergo retrotransposition by replicating and inserting into the genome via an RNA intermediate, in a ‘copy-and-paste' manner. LINE-1 neurodevelopment neurodevelopmental disorders retrotransposon © 2024 The Author(s) 2024 This is an open access article published by Portland Press...

.... I endeavour to highlight some of the critical questions that still require careful and concerted attention over the next decade to bring us closer to the goal of understanding the salient mechanisms whereby CHD8 deficiency causes neurodevelopmental disorders. Table 1. CHD8-interacting proteins...

... 2 2023 22 2 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 activity-regulated gene expression chromatin neurodevelopmental disorders Chromatin regulators have emerged as a major genetic contributor...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . CDKL5 deficiency disorder kinase neurodevelopmental disorders phosphorylation CDKL5 deficiency disorder (CDD) is a neurodevelopmental encephalopathy, characterized by early onset, refractory seizures and gross...

... signalling and physiology, including in brain function and development. Here, we review current knowledge on PP2A gene mutations causally involved in neurodevelopmental disorders and intellectual disability, focusing on PPP2CA , PPP2R1A and PPP2R5D . We provide insights into the impact of these mutations...

... in language and motor skills, as seen in many neurodevelopmental disorders (NDD). Recent widespread high-throughput approaches that utilize whole-exome sequencing or whole-genome sequencing have allowed for a considerable increase in the identification of these pathogenic variants in monogenic forms of ID...