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Keywords: neuroprotection
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Articles
Biochem Soc Trans (2014) 42 (3): 697–701.
Published: 22 May 2014
... muscle atrophy neuroprotection neurotrophic factor regeneration Peripheral nerve injuries, defined as those that affect any nerves outside the central nervous system, have been reported to affect 2.8% of trauma patients [ 1 ]. Injuries can range from compression of the nerve with no loss...
Articles
Biochem Soc Trans (2013) 41 (6): 1583–1587.
Published: 20 November 2013
... have multiple physiological roles including involvement in learning and memory, neuroinflammation, oxidative stress, neuroprotection and neurogenesis. They have also been implicated in the pathology of, or perhaps protective responses to, neurodegenerative diseases. This is particularly the case...
Articles
Biochem Soc Trans (2013) 41 (6): 1577–1582.
Published: 20 November 2013
... proliferation, indicating a critical role for both CB 1 and CB 2 receptors in the proliferation of NSC via IL-1 signalling pathways. Thus the endocannabinoid system, which has neuroprotective and immunomodulatory actions mediated by IL-1 signalling cascades in the brain, could assist the process...
Articles
Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
... • ), alkoxyl radicals (RO • ), peroxyradicals (ROO • ), hypochlorous acid (HOCl), nitric oxide (NO • ), peroxynitrite (ONOO − ), nitrogen dioxide ( • NO 2 ) and dinitrogen trioxide (N 2 O 3 ). antioxidant defence astrocyte neurodegeneration neuron neuroprotection oxidative stress ROS...
Articles
Biochem Soc Trans (2012) 40 (4): 656–660.
Published: 20 July 2012
... for intervention and clarify how tau pathology propagates from one brain region to the next. Tau fibrils transmit the neurotoxic process from diseased cells to healthy cells thus recapitulating the pattern observed by Braak and Braak [ 25 ]. Consequently one neuroprotective approach would be to block cell-to-cell...
Articles
Biochem Soc Trans (2009) 37 (6): 1147–1160.
Published: 19 November 2009
... trauma such as ischaemia and traumatic brain injury, as well as certain neurodegenerative diseases such as Huntington's disease. However, normal physiological patterns of NMDA receptor activity can promote neuroprotection against both apoptotic and excitotoxic insults. As a result, NMDA receptor blockade...
Articles
Biochem Soc Trans (2007) 35 (2): 428–432.
Published: 20 March 2007
...) and motor learning parameters (which are thought to be dependent on mesolimbocortical reward signalling) within the same task has revealed some surprising consequences of dopamine lesions and neuroprotective/neuroreparative approaches to repair in rat models of Parkinson's disease. The data generated using...
Articles
Biochem Soc Trans (2006) 34 (6): 1318–1322.
Published: 25 October 2006
... should be addressed (email alastair.buchan@ndm.ox.ac.uk ). 3 8 2006 © 2006 The Biochemical Society 2006 animal experiment intracerebral haemorrhage neuroprotection neurovascular imaging thrombolysis tissue plasminogen activator (tPA) A thrombo-embolic stroke results...
Articles
Biochem Soc Trans (2006) 34 (6): 1310–1312.
Published: 25 October 2006
...T. Yamashita; K. Deguchi; K. Sawamoto; H. Okano; T. Kamiya; K. Abe Possible strategies for treating ischaemic stroke include: (i) neuroprotection (preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischaemia), and (ii) neurosupplementation (the repair of broken...
Articles
Biochem Soc Trans (2006) 34 (6): 1323–1326.
Published: 25 October 2006
...M.D. Ginsberg; Y.Y. Palesch; M.D. Hill; for the ALIAS Trialists High-dose human ALB (albumin) therapy is highly neuroprotective in animal models of ischaemic stroke. A recently completed 82-subject pilot-phase dose-escalation trial has shown that ALB is safe, with strong preliminary suggestions...
Articles
Biochem Soc Trans (2006) 34 (6): 1327–1333.
Published: 25 October 2006
...C.-Z. Lu; B.-G. Xiao In several experimental studies of cerebral ischaemia, G-CSF (granulocyte colony-stimulating factor) exerted neuroprotective effects through different mechanisms, including mobilization of haemopoietic stem cells, anti-apoptosis, neuronal differentiation, angiogenesis and anti...
Articles
Biochem Soc Trans (2006) 34 (5): 936–938.
Published: 25 October 2006
...) excitotoxicity neuroprotection N -methyl- D -aspartate receptor (NMDA receptor) NMDARs [NMDA ( N -methyl- D -aspartate) receptors] are cation channels, gated by glutamate, the main excitatory neurotransmitter in the mammalian CNS (central nervous system). As well as passing Na + , NMDARs also pass Ca...
Articles
Biochem Soc Trans (2006) 34 (6): 1271–1276.
Published: 25 October 2006
...W.-R. Schäbitz; M. Fisher After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of recent study results. We outline in this review how a neuroprotective candidate drug should be developed, beginning with a thorough preclinical evaluation according...
Articles
Biochem Soc Trans (2006) 34 (6): 1352–1355.
Published: 25 October 2006
...S.L. Stevens; M.P. Stenzel-Poore Ischaemic tolerance in the brain is a powerful adaptive defence that involves an endogenous programme of neuroprotection culminating in marked protection against brain injury from ischaemia. A range of preconditioning stimuli exist that differ in ligand and target...
Articles
Biochem Soc Trans (2006) 34 (6): 1095–1097.
Published: 25 October 2006
...Y. Sun; S.P.H. Alexander; D.A. Kendall; A.J. Bennett Cannabinoids have been shown to possess anti-inflammatory and neuroprotective properties, which were proposed to occur mainly via activation of the G-protein-coupled receptor CB 1 (cannabinoid receptor 1). Recently, certain cannabinoids have been...
Articles
Biochem Soc Trans (2006) 34 (6): 1341–1346.
Published: 25 October 2006
... as a neuroprotective agent in cerebral ischaemia. Fibrates and other non-fibrate PPARα activators as well as thiazolidinediones and other non-thiazolidinedione PPARγ agonists have been demonstrated to induce both preventive and acute neuroprotection. This neuroprotective effect involves both cerebral and vascular...
Articles
Biochem Soc Trans (2001) 29 (6): 812–817.
Published: 01 November 2001
... of a mechanism preventing ROS production. UCP2 could therefore be involved in protecting the brain against oxidative stress. The involvement of UCP2 in neuroprotection is also consistent with the recent observation that kainic acid, which promotes Ca 2+ uptake in the glutamate-activated neurons...