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1-17 of 17
Keywords: neuroprotection
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Articles
Regenerative effects of adipose-tissue-derived stem cells for treatment of peripheral nerve injuries
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 697–701.
Published: 22 May 2014
... alternative to the nerve graft. 7 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 adipose-tissue-derived stem cell angiogenesis muscle atrophy neuroprotection neurotrophic factor regeneration Angiogenesis has long been recognized as being critical...
Articles
Endocannabinoid signalling in Alzheimer's disease
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1583–1587.
Published: 20 November 2013
... have multiple physiological roles including involvement in learning and memory, neuroinflammation, oxidative stress, neuroprotection and neurogenesis. They have also been implicated in the pathology of, or perhaps protective responses to, neurodegenerative diseases. This is particularly the case...
Articles
Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signalling
Available to PurchaseDaniel García-Ovejero, Ángel Arévalo-Martín, Beatriz Navarro-Galve, Emmanuel Pinteaux, Eduardo Molina-Holgado, Francisco Molina-Holgado
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1577–1582.
Published: 20 November 2013
... proliferation, indicating a critical role for both CB 1 and CB 2 receptors in the proliferation of NSC via IL-1 signalling pathways. Thus the endocannabinoid system, which has neuroprotective and immunomodulatory actions mediated by IL-1 signalling cascades in the brain, could assist the process...
Articles
Insight into a neuron's preferential susceptibility to oxidative stress
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
.... 2002 4 1 13 21 Bell K.F. Al-Mubarak B. Fowler J.H. Baxter P.S. Gupta K. Tsujita T. Chowdhry S. Patani R. Chandran S. Horsburgh K. Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning Proc...
Articles
Potential neuroprotective strategies against tauopathy
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 656–660.
Published: 20 July 2012
... ]. Consequently one neuroprotective approach would be to block cell-to-cell spreading. Further understanding of the mechanisms by which cells take up tau aggregates is needed. Several treatment strategies based on current understanding of tau neurotoxicity have reached clinical trials. These treatments...
Articles
Coupling of the NMDA receptor to neuroprotective and neurodestructive events
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1147–1160.
Published: 19 November 2009
... trauma such as ischaemia and traumatic brain injury, as well as certain neurodegenerative diseases such as Huntington's disease. However, normal physiological patterns of NMDA receptor activity can promote neuroprotection against both apoptotic and excitotoxic insults. As a result, NMDA receptor blockade...
Articles
Movement without dopamine: striatal dopamine is required to maintain but not to perform learned actions
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 428–432.
Published: 20 March 2007
...) and motor learning parameters (which are thought to be dependent on mesolimbocortical reward signalling) within the same task has revealed some surprising consequences of dopamine lesions and neuroprotective/neuroreparative approaches to repair in rat models of Parkinson's disease. The data generated using...
Articles
Pro-survival signalling from the NMDA receptor
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 936–938.
Published: 25 October 2006
... element (CRE)-binding protein (CREB) excitotoxicity neuroprotection N -methyl- D -aspartate receptor (NMDA receptor) In contrast with the deleterious effects of excessive NMDAR activity, physiological patterns of synaptic NMDAR activity actually promote neuronal survival. Elimination of NMDAR...
Articles
Perspectives on neuroprotective stroke therapy
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1271–1276.
Published: 25 October 2006
...W.-R. Schäbitz; M. Fisher After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of recent study results. We outline in this review how a neuroprotective candidate drug should be developed, beginning with a thorough preclinical evaluation according...
Articles
Translational vehicles for neuroprotection
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1318–1322.
Published: 25 October 2006
... ]. The approach to the CT (computed tomography) scan is to exclude any patients with haemorrhage or mass lesions from thrombolysis treatment. The focus is on vascular lesions as well as on early ischaemic changes. animal experiment intracerebral haemorrhage neuroprotection neurovascular imaging...
Articles
Neuroprotection and neurosupplementation in ischaemic brain
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1310–1312.
Published: 25 October 2006
...T. Yamashita; K. Deguchi; K. Sawamoto; H. Okano; T. Kamiya; K. Abe Possible strategies for treating ischaemic stroke include: (i) neuroprotection (preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischaemia), and (ii) neurosupplementation (the repair of broken...
Articles
The ALIAS (ALbumin In Acute Stroke) Phase III randomized multicentre clinical trial: design and progress report
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1323–1326.
Published: 25 October 2006
...M.D. Ginsberg; Y.Y. Palesch; M.D. Hill; for the ALIAS Trialists High-dose human ALB (albumin) therapy is highly neuroprotective in animal models of ischaemic stroke. A recently completed 82-subject pilot-phase dose-escalation trial has shown that ALB is safe, with strong preliminary suggestions...
Articles
G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1327–1333.
Published: 25 October 2006
...C.-Z. Lu; B.-G. Xiao In several experimental studies of cerebral ischaemia, G-CSF (granulocyte colony-stimulating factor) exerted neuroprotective effects through different mechanisms, including mobilization of haemopoietic stem cells, anti-apoptosis, neuronal differentiation, angiogenesis and anti...
Articles
Toll-like receptors and tolerance to ischaemic injury in the brain
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1352–1355.
Published: 25 October 2006
...S.L. Stevens; M.P. Stenzel-Poore Ischaemic tolerance in the brain is a powerful adaptive defence that involves an endogenous programme of neuroprotection culminating in marked protection against brain injury from ischaemia. A range of preconditioning stimuli exist that differ in ligand and target...
Articles
Cannabinoids and PPARα signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1095–1097.
Published: 25 October 2006
...Y. Sun; S.P.H. Alexander; D.A. Kendall; A.J. Bennett Cannabinoids have been shown to possess anti-inflammatory and neuroprotective properties, which were proposed to occur mainly via activation of the G-protein-coupled receptor CB 1 (cannabinoid receptor 1). Recently, certain cannabinoids have been...
Articles
PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases
Available to PurchaseR. Bordet, T. Ouk, O. Petrault, P. Gelé, S. Gautier, M. Laprais, D. Deplanque, P. Duriez, B. Staels, J.C. Fruchart, M. Bastide
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1341–1346.
Published: 25 October 2006
... as a neuroprotective agent in cerebral ischaemia. Fibrates and other non-fibrate PPARα activators as well as thiazolidinediones and other non-thiazolidinedione PPARγ agonists have been demonstrated to induce both preventive and acute neuroprotection. This neuroprotective effect involves both cerebral and vascular...
Articles
Uncoupling protein 2 in the brain: distribution and function
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (6): 812–817.
Published: 01 November 2001
... of a mechanism preventing ROS production. UCP2 could therefore be involved in protecting the brain against oxidative stress. The involvement of UCP2 in neuroprotection is also consistent with the recent observation that kainic acid, which promotes Ca 2+ uptake in the glutamate-activated neurons...