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Keywords: nitric oxide
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Articles
João S. Gonçalves, Ana L. Marçal, Bárbara S. Marques, Filipa D. Costa, João Laranjinha, Bárbara S. Rocha, Cátia F. Lourenço
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 279–289.
Published: 22 February 2024
... undergo sequential reduction reactions in vivo to produce nitric oxide ( • NO), a ubiquitous paracrine messenger that supports multiple physiological events such as vasodilation and neuromodulation. In the brain, • NO plays a key role in neurovascular coupling, a fine process associated with the dynamic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1447–1458.
Published: 23 August 2023
... signal for biofilm dispersal is the diatomic gas nitric oxide (NO). Low intracellular levels of NO have been well documented to rapidly disperse biofilm macrostructures and are sensed by a widely conserved NO - s ensory p rotein, NosP, in many pathogenic bacteria. When bound to heme and ligated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 495–505.
Published: 05 February 2021
.... This beneficial symbiosis is of importance in the context of sustainable agriculture as legumes do not require the addition of nitrogen fertilizer to grow. Interestingly, nitric oxide (NO) has been detected at various steps of the rhizobium–legume symbiosis where it has been shown to play multifaceted roles. Both...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2539–2555.
Published: 05 November 2020
...Amir M. Alsharabasy; Sharon A. Glynn; Abhay Pandit The extracellular matrix (ECM) dynamics in tumour tissue are deregulated compared to the ECM in healthy tissue along with disorganized architecture and irregular behaviour of the residing cells. Nitric oxide (NO) as a pleiotropic molecule exerts...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1107–1118.
Published: 06 September 2018
... and antimicrobial. We ask: is this definition of a gasotransmitter appropriate in the cases of nitric oxide, carbon monoxide and hydrogen sulfide (H 2 S) in microbes? Recent advances show that, not only do bacteria synthesise each of these gases, but the molecules also have important signalling or messenger roles...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 996–1000.
Published: 11 August 2014
... and to release vasodilator compounds, such as ATP and NO (nitric oxide), in response to tissue oxygenation. More recently it has been shown that RBCs are also able to produce NO endogenously as they express a functional NOS (nitric oxide synthase), similar to the endothelial isoform. In addition, RBCs carry...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 548–555.
Published: 20 March 2014
... and disease. MG is assayed by derivatization by 1,2-diaminobenzene derivatives in cell extracts. Such assays are not applicable to high sample throughput, subcellular, live-cell and in vivo estimations. The use of fluorogenic probes designed for NO (nitric oxide) detection in biological samples and living...
Articles
Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 108–113.
Published: 23 January 2014
...Opher Gileadi Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1633–1638.
Published: 21 November 2011
... (vascular endothelial growth factor) flow-dependent nitric oxide release in remodelling skeletal muscle microcirculation is established for elevated (activity, dilatation) and reduced (overload, ischaemia) shear stress, although their temporal relationship to angiogenesis varies. It is clear that growth...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1832–1837.
Published: 21 November 2011
... conditions and/or excessive ammonia loading, and the presence of high nitrite (NO 2 − ) concentrations, these bacteria are also documented to produce nitric oxide (NO) and nitrous oxide (N 2 O) gases. Essentially, ammonia oxidation in the presence of non-limiting substrate concentrations (ammonia and O 2...
Articles
Juan J. Cabrera, Cristina Sánchez, Andrew J. Gates, Eulogio J. Bedmar, Socorro Mesa, David J. Richardson, María J. Delgado
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1880–1885.
Published: 21 November 2011
...Juan J. Cabrera; Cristina Sánchez; Andrew J. Gates; Eulogio J. Bedmar; Socorro Mesa; David J. Richardson; María J. Delgado Nitric oxide (NO) is a gaseous signalling molecule which becomes very toxic due to its ability to react with multiple cellular targets in biological systems. Bacterial cells...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1886–1889.
Published: 21 November 2011
...María J. Torres; María I. Rubia; Eulogio J. Bedmar; María J. Delgado Denitrification is the complete reduction of nitrate or nitrite to N 2 , via the intermediates nitric oxide (NO) and nitrous oxide (N 2 O), and is coupled to energy conservation and growth under O 2 -limiting conditions...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 175–178.
Published: 19 January 2011
... and oceanic dead zones through algal bloom-induced hypoxia [ 7 ]. 1 To whom correspondence should be addressed (email [email protected] ). 19 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 ammonium nitrate nitric oxide nitrite nitrogen cycle...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 207–212.
Published: 19 January 2011
.... Agrobacterium tumefaciens denitrification denitrification regulatory phenotype (DRP) nitric oxide nitrous oxide Paracoccus denitrificans Microbial life and proliferation in environments such as soil is filled with challenges. Frequent fluctuations in the availability of carbon, nutrients...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 213–215.
Published: 19 January 2011
... The Authors Journal compilation © 2011 Biochemical Society 2011 anaerobiosis Escherichia coli nitric oxide nitric oxide reductase nitrosative stress The ability of both pathogenic and free living bacteria to protect themselves against nitrosative stress is critical to their survival...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 289–293.
Published: 19 January 2011
...Matthew Bush; Tamaswati Ghosh; Nicholas Tucker; Xiaodong Zhang; Ray Dixon A flavorubredoxin and its associated oxidoreductase (encoded by norV and norW respectively) detoxify NO (nitric oxide) to form N 2 O (nitrous oxide) under anaerobic conditions in Escherichia coli . Transcription of the norVW...
Articles
Cristina Sánchez, Juan J. Cabrera, Andrew J. Gates, Eulogio J. Bedmar, David J. Richardson, María J. Delgado
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 184–188.
Published: 19 January 2011
...Cristina Sánchez; Juan J. Cabrera; Andrew J. Gates; Eulogio J. Bedmar; David J. Richardson; María J. Delgado NO (nitric oxide) is a signal molecule involved in diverse physiological processes in cells which can become very toxic under certain conditions determined by its rate of production...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 294–298.
Published: 19 January 2011
...Giorgio Giardina; Nicoletta Castiglione; Manuela Caruso; Francesca Cutruzzolà; Serena Rinaldo In response to environmental conditions, NO (nitric oxide) induces global changes in the cellular metabolism of Pseudomonas aeruginosa , which are strictly related to pathogenesis. In particular, at low...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 219–223.
Published: 19 January 2011
... is the detoxification of NO (nitric oxide) to nitrate by the flavohaemoglobin enzyme CaYhb1. Members of the haemoglobin superfamily are highly conserved and are found in archaea, eukaryotes and bacteria. Flavohaemoglobins have a dioxygenase activity [NOD (NO dioxygenase domain)] and contain three domains: a globin...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 195–200.
Published: 19 January 2011
...Serena Rinaldo; Giorgio Giardina; Nicoletta Castiglione; Valentina Stelitano; Francesca Cutruzzolà The cd 1 NiRs (nitrite reductases) are enzymes catalysing the reduction of nitrite to NO (nitric oxide) in the bacterial energy conversion denitrification process. These enzymes contain two distinct...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1243–1247.
Published: 19 November 2009
...Lorna R. Fiedler; Beata Wojciak-Stothard ADMA (asymmetric dimethylarginine) is a cardiovascular risk factor and an endogenous inhibitor of NOS (nitric oxide synthase). ADMA is metabolized by DDAHs (dimethylarginine dimethylaminohydrolases). ADMA levels are increased in cardiovascular disorders...
Articles
Christian Hesslinger, Andreas Strub, Rainer Boer, Wolf-Rüdiger Ulrich, Martin D. Lehner, Clemens Braun
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 886–891.
Published: 22 July 2009
...Christian Hesslinger; Andreas Strub; Rainer Boer; Wolf-Rüdiger Ulrich; Martin D. Lehner; Clemens Braun Nitric oxide (NO) is a key physiological mediator and disturbed regulation of NO release is associated with the pathophysiology of almost all inflammatory diseases. A multitude of inhibitors...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (2): 368–372.
Published: 20 March 2009
... and mechanistic insights that may be afforded by working with such electrodes through studies of Escherichia coli NrfA, a pentahaem cytochrome with nitrite and nitric oxide reductase activities. In addition, we demonstrate that the ability to characterize electrocatalytically active protein films by MCD (magnetic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (2): 392–399.
Published: 20 March 2009
...Nicholas J. Watmough; Sarah J. Field; Ross J. L. Hughes; David J. Richardson The two-subunit cytochrome bc complex (NorBC) isolated from membranes of the model denitrifying soil bacterium Paracoccus denitrificans is the best-characterized example of the bacterial respiratory nitric oxide reductases...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1160–1164.
Published: 19 November 2008
... and the signals that they sense has greatly increased. The present article reviews recent developments, with a particular focus on bacterial sensors of nitric oxide. Transcriptional regulators containing transition metal cofactors provide effective mechanisms for controlling gene expression in response...
Articles
Serena Rinaldo, Alessandro Arcovito, Giorgio Giardina, Nicoletta Castiglione, Maurizio Brunori, Francesca Cutruzzolà
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1155–1159.
Published: 19 November 2008
...Serena Rinaldo; Alessandro Arcovito; Giorgio Giardina; Nicoletta Castiglione; Maurizio Brunori; Francesca Cutruzzolà The cytochrome cd 1 nitrite reductases are enzymes that catalyse the reduction of nitrite to nitric oxide (NO) in the bacterial energy conversion denitrification process...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1119–1121.
Published: 25 October 2007
...G.C. Brown Inflammation contributes to a wide variety of brain pathologies, apparently via glia killing neurons. A number of mechanisms by which inflammatory-activated microglia and astrocytes kill neurons have been identified in culture. These include iNOS (inducible nitric oxide synthase), which...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1133–1137.
Published: 25 October 2007
...S. Murphy; C.L. Gibson Cerebral ischaemia results in the activation of three isoforms of NOS (nitric oxide synthase) that contribute to the development of and recovery from stroke pathology. This review discusses, in particular, the role of the transcriptionally activated NOS-2 (inducible NOS...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1138–1141.
Published: 25 October 2007
...L. Li; P.K. Moore Biologically active gases that occur naturally in the body include nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H 2 S). Each of these molecules is synthesized by enzymes which have been characterized biochemically and pharmacologically, and each acts, via well...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1258–1263.
Published: 25 October 2007
...O. Pierrefiche; A.P.L. Abdala; J.F.R. Paton NO (nitric oxide) modulates several central pattern generators, but its role in respiratory rhythmogenesis and its mode of action on medullary respiratory neurons during normoxia are unknown. We analysed the actions of NO on the mammalian respiratory...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 191–194.
Published: 20 January 2006
...N.P. Tucker; B. D'Autréaux; S. Spiro; R. Dixon Nitric oxide (NO) is a highly reactive water-soluble gas encountered by bacteria endogenously as an intermediate of denitrification and exogenously as one of the radical species deployed by macrophages against invading pathogens. Bacteria therefore...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 195–196.
Published: 20 January 2006
...G.E. Meakin; B.J.N. Jepson; D.J. Richardson; E.J. Bedmar; M.J. Delgado The identification of nitric oxide-bound leghaemoglobin within soya bean nodules has led to the question of how Bradyrhizobium japonicum bacteroids overcome the toxicity of this nitric oxide. It has previously been shown...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 197–199.
Published: 20 January 2006
... meningitis. Following activation, macrophages produce superoxide (O 2 − ), hydrogen peroxide (H 2 O 2 ) and nitric oxide (NO). The toxicity of O 2 − , generated using X/Xo (xanthine/xanthine oxidase), and H 2 O 2 was investigated in the presence and absence of the NO donor DEA-NONOate [2-( N , N...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 200–202.
Published: 20 January 2006
...S. Spiro Exposure of Escherichia coli to nitric oxide (NO) or nitrosating agents causes significant changes in patterns of gene expression. Three recent studies have used microarrays to analyse the response of the E. coli transcriptome to NO and nitrosative stress. Drawing on the array data, I...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 130–132.
Published: 20 January 2006
... to the reactive molecule nitric oxide. Further study demonstrated that HCNT1 does not encode the genes for NO reductase. Prolonged incubation of HCNT1 under anoxic conditions revealed that the cells had reduced culturability but not viability when nitrite was present. This may indicate an adaptation to anoxic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 182–184.
Published: 20 January 2006
...R. Cramm; A. Büsch; K. Strube The σ54-dependent transcriptional regulator NorR of Ralstonia eutropha H16 activates gene expression in response to nitric oxide (NO). The N-terminal domain of NorR is thought to be involved in signal perception. A C112S exchange within this domain abolished promoter...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 185–187.
Published: 20 January 2006
...S. Rinaldo; G. Giardina; M. Brunori; F. Cutruzzolà All denitrifiers can keep the steady-state concentrations of nitrite and nitric oxide (NO) below cytotoxic levels by controlling the expression of denitrification gene clusters by redox signalling through transcriptional regulators belonging...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1399–1403.
Published: 26 October 2005
... ]. The NO production during mild-to-moderate hypoxic conditions may be prolonged or even increased through an enhanced activity and expression of endothelial NOS (nitric oxide synthase) [ 22 , 23 ]. Additionally, chronic hypoxia may lead to an up-regulation of mitochondrial NOS activity [ 24 ]. A possible interaction...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 176–180.
Published: 01 February 2005
...R.K. Poole Nitric oxide is not only an obligatory intermediate in denitrification, but also a signalling and defence molecule of major importance. However, the basis of resistance to NO and RNS (reactive nitrogen species) is poorly understood in many microbes. The cellular targets of NO and RNS...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 113–118.
Published: 01 February 2005
... to study bioenergetics and bioinorganic chemistry. These respiratory reactions involve the reduction of dinitrogen, nitrate, nitrite, nitric oxide and nitrous oxide, and the oxidation of ammonium and hydroxylamine. In each case, catalysis involves redox chemistry that takes place at metal centres...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 184–186.
Published: 01 February 2005
... to get some insights of the DNR structural organization. The emission of ANS increases when the molecule is bound in a non-polar environment with a shift in the wavelength of maximum emission from approx. 530 to below 500 nm. anaerobiosis denitrification nitric oxide Pseudomonas aeruginosa...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 190–192.
Published: 01 February 2005
... at the level of the primary dehydrogenase and not from quinol oxidation. © 2005 The Biochemical Society 2005 Campylobacter Nap nitrate nitric oxide nitrite Nrf What electron acceptors are likely to be important for the growth of C. jejuni in vivo ? As it possesses a cb -type...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 193–194.
Published: 01 February 2005
...A. Büsch; K. Strube; B. Friedrich; R. Cramm Nitric oxide reduction in Ralstonia eutropha H16 is catalysed by the quinol-dependent NO reductase NorB. norB and the adjacent norA form an operon that is controlled by the σ 54 -dependent transcriptional activator NorR in response to NO. A NorR...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 187–189.
Published: 01 February 2005
... was increased, indicating that, at higher pH, there is an increase in the high-spin state of the protein. cytochrome c ′ Neisseria meningitidis nitrosyl complex nitric oxide purification spectroscopy Cytochrome c ′, a cytochrome with a C-terminal, covalently attached haem and unusual...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 198–199.
Published: 01 February 2005
... cytochrome c nitrite reductase flavohaemoglobin flavorubredoxin macrophage nitric oxide Salmonella During infection, cells of pathogenic Salmonella species are typically internalized into free macrophages and the fixed macrophages of the liver and spleen. Here, bacterial cells are enclosed...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1447–1449.
Published: 01 December 2003
... of lower levels of endothelial-derived nitric oxide. The mechanisms involved in vascular dysfunction are not entirely understood, but age-related alterations in eNOS (endothelial nitric oxide synthase) activity appear to be a likely source of the aging lesion. However, age-related changes in cell...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1450–1452.
Published: 01 December 2003
...C.M. Shah; I.C. Locke; H.S. Chowdrey; M.P. Gordge RSNOs (S-nitrosothiols) regulate platelet and megakaryocyte function, and may act in vivo as a nitric oxide reservoir. There is a discrepancy between the spontaneous rate of NO release from different RSNO compounds and their pharmacological effects...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 1059–1061.
Published: 01 October 2003
... for the response to injury. Oxidant stress in atherothrombosis In chronic diseases such as atherothrombosis, however, ROS are responsible for the initiation and perpetuation of Key words: antioxidant, endothelial function, nitric oxide, reactive oxygen species. Abbreviations used: eNOS, endothelial NO synthase...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 553–557.
Published: 01 June 2003
...D.M. Lawson; C.E.M. Stevenson; C.R. Andrew; S.J. George; R.R. Eady Cytochrome c ´ (cyt c ´) is found in the periplasmic space of denitrifying bacteria where it is thought to mediate the transfer of NO between the nitrogen-cycle enzymes dissimilatory nitrite reductase and nitric oxide reductase...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 502–505.
Published: 01 June 2003
...S. Daff The nitric oxide synthases are large, modular, dimeric enzymes composed of a reductase domain, which is related to cytochrome P450 reductase, and a structurally unique oxygenase domain containing a Cys-ligated haem. Both the neuronal and endothelial isoforms are activated by the reversible...
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