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Keywords: nuclear factor κB (NF-κB)
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Articles

Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway

Colin E. Murdoch, Markus M. Bachschmid, Reiko Matsui
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1665–1670.
https://doi.org/10.1042/BST20140213
Published: 17 November 2014
... signalling function to proteins with redox-sensitive thiols. Glrx can regulate vascular hypertrophy and inflammation by regulating the activity of nuclear factor κB (NF-κB) and actin polymerization. Vascular endothelial growth factor (VEGF)-induced endothelial cell (EC) migration is inhibited by Glrx...
View articletitled, Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway
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Articles

NF-κB and the cell cycle

Adeline C. Ledoux, Neil D. Perkins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 76–81.
https://doi.org/10.1042/BST20130156
Published: 23 January 2014
[email protected] ). 17 7 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer cell cycle cyclin D1 mitosis nuclear factor κB (NF-κB) p53 NF-κB (nuclear factor κB) consists of the homo- and hetero-dimers formed from a family of five transcription factors...
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Articles

The impact of hypoxia on cell death pathways

Colin R. Lenihan, Cormac T. Taylor
Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (2): 657–663.
https://doi.org/10.1042/BST20120345
Published: 21 March 2013
... be addressed (email [email protected] ). 22 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 apoptosis B-cell lymphoma (Bcl) hypoxia nuclear factor κB (NF-κB) In contrast, the intrinsic pathway is primarily activated in response to cell stress or injury...
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Articles

Genetic relationships between A20/TNFAIP3 , chronic inflammation and autoimmune disease

Lars Vereecke, Rudi Beyaert, Geert van Loo
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 1086–1091.
https://doi.org/10.1042/BST0391086
Published: 20 July 2011
... The Authors Journal compilation © 2011 Biochemical Society 2011 A20 autoimmunity B-cell inflammatory bowel disease (IBD) nuclear factor κB (NF-κB) tumour necrosis factor α-induced protein 3 (TNFAIP3) DSS dextran sodium sulfate DUB deubiquitinating GWAS genome-wide...
View articletitled, Genetic relationships between A20/TNFAIP3 , chronic inflammation and autoimmune disease
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Articles

Spatial and temporal information coding and noise in the NF-κB system

Marco Marcello, Michael R.H. White
Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1247–1250.
https://doi.org/10.1042/BST0381247
Published: 24 September 2010
... be addressed to either author (email [email protected] or [email protected] ). 8 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression regulation inflammatory response nuclear factor κB (NF-κB) oscillation phosphorylation single-cell...
View articletitled, Spatial and temporal information coding and noise in the NF-κB system
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Articles

Antiviral activity of resveratrol

Michela Campagna, Carmen Rivas
Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (1): 50–53.
https://doi.org/10.1042/BST0380050
Published: 19 January 2010
... be addressed (email [email protected] ). 26 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 antiviral activity nuclear factor κB (NF-κB) p53 resveratrol virus Resveratrol (3,4′,5-trihydroxy- trans -stilbene) is a phenolic compound produced by various...
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Articles

Regulation of cyclin D1 gene expression

Ini-Isabée Witzel, Li Fang Koh, Neil D. Perkins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (1): 217–222.
https://doi.org/10.1042/BST0380217
Published: 19 January 2010
... be addressed (email [email protected] ). 17 7 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 cyclin D1 nuclear factor κB (NF-κB) RNA processing Smad nuclear interacting protein 1 (SNIP1) transcription The CCND1 gene-encoded cyclin D1 protein...
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Articles

Regulation of the RelA (p65) transactivation domain

John M. O'shea, Neil D. Perkins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 603–608.
https://doi.org/10.1042/BST0360603
Published: 22 July 2008
... proteins. Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function. © The Authors Journal compilation © 2008 Biochemical Society 2008 co-activator co-repressor nuclear factor κB...
View articletitled, Regulation of the RelA (p65) transactivation domain
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Includes: Supplementary data
Articles

Role of NF-κB in β-cell death

Danielle Melloul
Journal: Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 334–339.
https://doi.org/10.1042/BST0360334
Published: 21 May 2008
[email protected] 3 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis β-cell cytokine islet graft rejection nuclear factor κB (NF-κB) Type 1 diabetes Type 1 and Type 2 are the two main forms of diabetes mellitus. T1DM (Type 1 diabetes mellitus...
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Articles

Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2

Andrew G. Bowie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 449–452.
https://doi.org/10.1042/BST0360449
Published: 21 May 2008
... Biochemical Society 2008 intracellular signalling interleukin-1-receptor-associated kinase (IRAK) nuclear factor κB (NF-κB) Toll-like receptor tumour-necrosis-factor-receptor-associated factor-6 (TRAF-6) vaccinia virus The formation of these receptor/adaptor complexes then triggers...
View articletitled, Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2
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Articles

Nod1 and Nod2 in innate immunity and human inflammatory disorders

L. Le Bourhis, S. Benko, S.E. Girardin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1479–1484.
https://doi.org/10.1042/BST0351479
Published: 23 November 2007
...) nuclear factor κB (NF-κB) pattern-recognition molecule (PRM) Sensing and defeating microbial infections is essential for the survival of metazoan species. All living organisms are constantly exposed to microbes that are, most of the time, neutral or beneficial to the host, but sometimes cause...
View articletitled, Nod1 and Nod2 in innate immunity and human inflammatory disorders
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Articles

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins

K. Kersse, T. Vanden Berghe, M. Lamkanfi, P. Vandenabeele
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1508–1511.
https://doi.org/10.1042/BST0351508
Published: 23 November 2007
... domain (ASC) caspase 1 caspase recruitment domain (CARD) inflammation interleukin-1β (IL-1β) nuclear factor κB (NF-κB) Caspase 1 was the first member of an evolutionarily conserved family of cysteine-dependent aspartate-specific proteases, better known as caspases, to be reported. Originally...
View articletitled, A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins
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Articles

Ubiquitin signals in the NF-κB pathway

J. Terzic, I. Marinovic-Terzic, F. Ikeda, I. Dikic
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 942–945.
https://doi.org/10.1042/BST0350942
Published: 25 October 2007
... Journal compilation © 2007 Biochemical Society 2007 de-ubiquitinating enzyme inhibitory κB kinase (IKK) nuclear factor κB (NF-κB) transcription factor tumour necrosis factor receptor (TNFR) ubiquitination The NF-κB (nuclear factor κB) transcription factors are key regulators of immune...
View articletitled, Ubiquitin signals in the NF-κB pathway
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Articles

Protein transduction: identification, characterization and optimization

J. Tilstra, K.K. Rehman, T. Hennon, S.E. Plevy, P. Clemens, P.D. Robbins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 811–815.
https://doi.org/10.1042/BST0350811
Published: 20 July 2007
...-penetrating peptide (CPP) inflammation nuclear factor κB (NF-κB) protein transduction domain PTDs (protein transduction domains) or CPPs (cell-penetrating peptides) are small peptides which are able to carry much larger molecules such as oligonucleotides, peptides, full-length proteins, 40 nm iron...
View articletitled, Protein transduction: identification, characterization and optimization
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Articles

The role of SHIP1 in T-lymphocyte life and death

G. Gloire, C. Erneux, J. Piette
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 277–280.
https://doi.org/10.1042/BST0350277
Published: 20 March 2007
... ] T-cells H 2 O 2 Anti-apoptotic [ 38 ] 1 To whom correspondence should be addressed (email [email protected] ). 9 9 2006 © 2007 The Biochemical Society 2007 apoptosis cell proliferation nuclear factor κB (NF-κB) phosphoinositide 3-kinase (PI3K...
View articletitled, The role of SHIP1 in T-lymphocyte life and death
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Articles

Resolution of Inflammatory Responses: a brief introduction

I. Adcock, P.C. Evans
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 261–262.
https://doi.org/10.1042/BST0350261
Published: 20 March 2007
... Kirkham P. Biochem. Soc. Trans. 2007 35 284 287 11 Rossi A.G. Hallett J.M. Sawatzky D.A. Teixeira M.M. Haslett C. Biochem. Soc. Trans. 2007 35 288 291 inflammation inhibitor of nuclear factor κB (IκB) nuclear factor κB (NF-κB) phagocytosis post...
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Articles

Impact of post-translational modifications of proteins on the inflammatory process

K. Ito
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 281–283.
https://doi.org/10.1042/BST0350281
Published: 20 March 2007
... © 2007 The Biochemical Society 2007 acetylation chronic obstructive pulmonary disease (COPD) glucocorticoid histone deacetylase (HDAC) nuclear factor κB (NF-κB) post-translational modification PTM (post-translational modification) is the chemical modification of a protein after...
View articletitled, Impact of post-translational modifications of proteins on the inflammatory process
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Articles

Single-cell time-lapse imaging of the dynamic control of NF-κB signalling

K. Sillitoe, C. Horton, D.G. Spiller, M.R.H. White
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 263–266.
https://doi.org/10.1042/BST0350263
Published: 20 March 2007
... The Biochemical Society 2007 inflammatory response nuclear factor κB (NF-κB) oscillation RelA single-cell imaging The NF-κB signalling pathway has been shown to be active in virtually all cell types and to regulate a number of essential cellular functions. These include inflammation, apoptosis...
View articletitled, Single-cell time-lapse imaging of the dynamic control of NF-κB signalling
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Articles

The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses

S. Weldon, N. McGarry, C.C. Taggart, N.G. McElvaney
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 273–276.
https://doi.org/10.1042/BST0350273
Published: 20 March 2007
... antiprotease host response inflammatory lung disease monocyte nuclear factor κB (NF-κB) secretory leucoprotease inhibitor (SLPI) Human SLPI (secretory leucoprotease inhibitor) was originally isolated from secretions of patients with COPD (chronic obstructive pulmonary disease) and CF (cystic...
View articletitled, The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses
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Articles

Control of the NF-κB inhibitor IκBα in pathogen infection

M. Naumann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 267–269.
https://doi.org/10.1042/BST0350267
Published: 20 March 2007
... factor κB α kinase complex (IKK complex) NEDD8 nuclear factor κB (NF-κB) β-transducin repeat-containing protein (β-TrCP) In most cases the epithelial cell layer represents the first barrier for microbial pathogens and triggers the innate and inflammatory responses in the host. Subsequent...
View articletitled, Control of the NF-κB inhibitor IκBα in pathogen infection
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Articles

IKKα in the regulation of inflammation and adaptive immunity

T. Lawrence, M. Bebien
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 270–272.
https://doi.org/10.1042/BST0350270
Published: 20 March 2007
...) inflammation inhibitor of nuclear factor κB kinase (IKK) nuclear factor κB (NF-κB) 1 To whom correspondence should be addressed (email [email protected] ). 1 11 2006 © 2007 The Biochemical Society 2007 Resolution of Inflammatory Responses: Signalling Networks...
View articletitled, IKKα in the regulation of inflammation and adaptive immunity
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Articles

De-ubiquitinating enzymes: intracellular signalling and disease

J.A. Johnston, J.F. Burrows
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 764–769.
https://doi.org/10.1042/BST0340764
Published: 25 October 2006
... 2006 The Biochemical Society 2006 de-ubiquitinating enzyme DNA repair ovarian tumour protease intracellular signalling nuclear factor κB (NF-κB) ubiquitin C-terminal hydrolase Over the last decade, it has become apparent that ubiquitination plays a fundamental role in the regulation...
View articletitled, De-ubiquitinating enzymes: intracellular signalling and disease
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Articles

NF-κB signalling in cerebral ischaemia

M. Schwaninger, I. Inta, O. Herrmann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1291–1294.
https://doi.org/10.1042/BST0341291
Published: 25 October 2006
... κB (IκB) kinase (IKK) nuclear factor κB (NF-κB) stroke tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) Stroke is a frequent clinical disorder. The WHO (World Health Organization) estimates that worldwide 5–6 million people die from strokes every year. Thrombolysis has...
View articletitled, NF-κB signalling in cerebral ischaemia
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Articles

Post-translational modification of RelA(p65) NF-κB

K.J. Campbell, N.D. Perkins
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1087–1089.
https://doi.org/10.1042/BST0321087
Published: 26 October 2004
... total NF-κB inhibition. 1 To whom correspondence should be addressed (email [email protected] ). 5 7 2004 © 2004 The Biochemical Society 2004 chemotherapy nuclear factor κB (NF-κB) post-translational modification RelA transcription UV light NF-κB...
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Articles

Characterization of the survival effect of tumour necrosis factor-α in human neutrophils

S.R. Walmsley, A.S. Cowburn, A. Sobolewski, J. Murray, N. Farahi, I. Sabroe, E.R. Chilvers
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (3): 456–460.
https://doi.org/10.1042/bst0320456
Published: 01 June 2004
... neutrophil nuclear factor κB (NF-κB) phosphoinositide 3-kinase tumour necrosis factor-α Abbreviations used: BAL, bronchoalveolar lavage; GM-CSF, granulocyte/macrophage colony-stimulating factor; I-κBα, inhibitory κB-α; IL-2, interleukin-2; mAb, monoclonal antibody; MDM, Iscove's modified...
View articletitled, Characterization of the survival effect of tumour necrosis factor-α in human neutrophils
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Articles

B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB) via a mechanism that involves diacylglycerol

P. Antony, J.B. Petro, G. Carlesso, N.P. Shinners, J. Lowe, W.N. Khan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 113–115.
https://doi.org/10.1042/bst0320113
Published: 01 February 2004
...-cells (NFAT) nuclear factor κB (NF-κB) phospholipase C-γ2 Abbreviations used: BCR, B-cell antigen receptor; BTK, Bruton's tyrosine kinase; PLC-γ2, phospholipase C-γ2; LSM, lipid second messenger; DAG, diacylglycerol; NFAT, nuclear factor of activated T-cells; NF-κB, nuclear factor κB; PKC...
View articletitled, B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB) via a mechanism that involves diacylglycerol
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