...Yu Chen; Guoli Zhou; Miao Yu The nuclear pore complex (NPC) is a vital regulator of molecular transport between the nucleus and cytoplasm in eukaryotic cells. At the heart of the NPC’s function are intrinsically disordered phenylalanineglycine-rich nucleoporins (FG-Nups), which form a dynamic...

... histones importins karyopherins nuclear pore complex nuclear protein transport The compartmentalization of the cell into nucleus and cytoplasm is a major feature of all eukaryotic cells. The nuclear envelope separates DNA in the nucleus from protein synthesis process, which occurs...

..., we focus on a subset of nuclear envelope herniations that likely arise as a consequence of disrupting physiological nuclear membrane remodeling pathways required to maintain nuclear envelope homeostasis. For example, stalling of the interphase nuclear pore complex (NPC) biogenesis pathway...

... contain high levels of the small G protein RanGTP, whereas the cytoplasm contains high levels of Ran-GDP ( Figure 3 ). In the cytoplasm, NLS-containing proteins bind to importin receptors for transport across the NPC (nuclear pore complex) where high levels of Ran-GTP in the nuclear compartment dissociate...

... as their NE targeting mechanisms. © The Authors Journal compilation © 2010 Biochemical Society 2010 Arabidopsis higher plant nuclear envelope (NE) nuclear pore complex Sad1/UNC-84 (SUN) domain Nuclear Envelope Disease and Chromatin Organization 2009: Independent Meeting held...

...M. Stewart Transport of macromolecules between the nuclear and cytoplasmic compartments through NPCs (nuclear pore complexes) is mediated by soluble transport factors that are commonly members of the importin-β superfamily. In the nuclear protein import cycle, importin-β binds cargo...