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Keywords: nucleus
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Biochem Soc Trans (2023) 51 (5): 1947–1956.
Published: 16 October 2023
... the similarities that the anionic polyP shares with the better-understood negatively charged polymers DNA and RNA, postulating that the nucleus offers an ideal environment where polyP physiology might thrive. One important aspect of polyP is its polyanionic nature. The negative charges of the more famed...
Biochem Soc Trans (2018) 46 (4): 877–889.
Published: 19 July 2018
...David J. Thaller; C. Patrick Lusk Morphological abnormalities of the bounding membranes of the nucleus have long been associated with human diseases from cancer to premature aging to neurodegeneration. Studies over the past few decades support that there are both cell intrinsic and extrinsic...
Biochem Soc Trans (2018) 46 (1): 173–182.
Published: 06 February 2018
... in providing a physical separation between the genome and the cytoplasm and regulating the exchanges between the two cellular compartments, it has become quite evident in recent years that the NE also represents a hub for localized signal transduction. Mechanical, stress, or mitogen signals reach the nucleus...
Biochem Soc Trans (2017) 45 (6): 1279–1293.
Published: 10 November 2017
... 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 lamin lamin A/C nucleus premature aging progeria Vitamin D is crucial for maintaining calcium and phosphate homeostasis, and most genomic activities of vitamin D are mediated...
Biochem Soc Trans (2016) 44 (6): 1701–1708.
Published: 02 December 2016
... and microtubule dynamics. Not surprisingly, formins are best known as key regulators of the cytoskeleton in a variety of morphogenetic processes. However, mounting evidence implicates several formins in the assembly and organization of actin within and around the nucleus. In addition, actin-independent roles...
Biochem Soc Trans (2016) 44 (1): 299–306.
Published: 09 February 2016
...Nullin Divecha Phosphoinositides are a family of phospholipid messenger molecules that control various aspects of cell biology in part by interacting with and regulating downstream protein partners. Importantly, phosphoinositides are present in the nucleus. They form part of the nuclear envelope...
Biochem Soc Trans (2014) 42 (3): 645–649.
Published: 22 May 2014
... and structural components of the cell responsible for transducing external mechanical forces into biochemical signalling cascades, only recently have studies begun to examine how mechanical signals are transmitted to the nucleus and activate specific gene expression programmes. One necessary step...
Biochem Soc Trans (2013) 41 (6): 1629–1633.
Published: 20 November 2013
... genome. 1 email Zaratiegui@dls.rutgers.edu 30 8 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 centromere protein B (CENP-B) genomics long terminal repeat (LTR) nucleus retrotransposon RNA interference (RNAi) TEs (transposable elements...
Biochem Soc Trans (2012) 40 (1): 67–72.
Published: 19 January 2012
... differentiation of sympathetic neurons and was associated with sustained ERK activation. Sustained ERK activation was associated with the presence of ERK in the nucleus, whereas transient activation did not lead to nuclear ERK activation and it was suggested that this difference allowed for a qualitative...
Biochem Soc Trans (2011) 39 (6): 1729–1734.
Published: 21 November 2011
...Maria L. Lombardi; Jan Lammerding Providing a stable physical connection between the nucleus and the cytoskeleton is essential for a wide range of cellular functions and it could also participate in mechanosensing by transmitting intra- and extra-cellular mechanical stimuli via the cytoskeleton...
Biochem Soc Trans (2005) 33 (5): 1137–1139.
Published: 26 October 2005
.... It does however appear to be localized within the nucleus of the cell. Figure 1 Down-regulation of L-type calcium channels Lysates extracted from normal (lanes 1 and 3), hypoxic- (lane 2) and DFX-treated (lane 4) cells were resolved by SDS/PAGE (7.5% polyacrylamide), transferred...
Biochem Soc Trans (2003) 31 (5): 907–911.
Published: 01 October 2003
... fluorescent protein nucleus phospholipase C protein kinase C (PKC) sperm Abbreviations used: IP 3 , inositol 1,4,5-trisphosphate; PLC, phospholipase C; IP 3 R, IP 3 receptor; PKC, protein kinase C; PIP 2 , phosphatidylinositol 4,5-bisphosphate; PH, pleckstrin homology; GFP, green fluorescent...