... the similarities that the anionic polyP shares with the better-understood negatively charged polymers DNA and RNA, postulating that the nucleus offers an ideal environment where polyP physiology might thrive. Correspondence: Adolfo Saiardi ( [email protected] ) 14 9 2023 6 10 2023 10 10...

...David J. Thaller; C. Patrick Lusk Morphological abnormalities of the bounding membranes of the nucleus have long been associated with human diseases from cancer to premature aging to neurodegeneration. Studies over the past few decades support that there are both cell intrinsic and extrinsic...

... in providing a physical separation between the genome and the cytoplasm and regulating the exchanges between the two cellular compartments, it has become quite evident in recent years that the NE also represents a hub for localized signal transduction. Mechanical, stress, or mitogen signals reach the nucleus...

... 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 lamin lamin A/C nucleus premature aging progeria Vitamin D is crucial for maintaining calcium and phosphate homeostasis, and most genomic activities of vitamin D are mediated...

... and microtubule dynamics. Not surprisingly, formins are best known as key regulators of the cytoskeleton in a variety of morphogenetic processes. However, mounting evidence implicates several formins in the assembly and organization of actin within and around the nucleus. In addition, actin-independent roles...

...Nullin Divecha Phosphoinositides are a family of phospholipid messenger molecules that control various aspects of cell biology in part by interacting with and regulating downstream protein partners. Importantly, phosphoinositides are present in the nucleus. They form part of the nuclear envelope...

... and structural components of the cell responsible for transducing external mechanical forces into biochemical signalling cascades, only recently have studies begun to examine how mechanical signals are transmitted to the nucleus and activate specific gene expression programmes. One necessary step...

... genome. 1 email [email protected] 30 8 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 centromere protein B (CENP-B) genomics long terminal repeat (LTR) nucleus retrotransposon RNA interference (RNAi) TEs (transposable elements...

... of ERKs proposes that MEK acts to anchor ERK in the cytoplasm in resting cells but, on mitogen stimulation, this complex dissociates, and allows entry of active ERK into the nucleus, where it is able to activate nuclear substrates [ 13 ]. Mechanisms involved in terminating the activity of ERK...

...Maria L. Lombardi; Jan Lammerding Providing a stable physical connection between the nucleus and the cytoskeleton is essential for a wide range of cellular functions and it could also participate in mechanosensing by transmitting intra- and extra-cellular mechanical stimuli via the cytoskeleton...

... to the nucleus, bind to HIF-1β and form HIF-1. This is a transcriptional activator of many genes including erythropoietin and vascular endothelial growth factor [ 3 ]. The down-regulation of the L-type channel in both hypoxic- and DFX-treated cells indicates that the mechanism of down-regulation is via the HIF...

... fluorescent protein nucleus phospholipase C protein kinase C (PKC) sperm Abbreviations used: IP 3 , inositol 1,4,5-trisphosphate; PLC, phospholipase C; IP 3 R, IP 3 receptor; PKC, protein kinase C; PIP 2 , phosphatidylinositol 4,5-bisphosphate; PH, pleckstrin homology; GFP, green fluorescent...

...L. Santella; E. Ercolano; D. Lim; G.A. Nusco; F. Moccia Starfish oocytes that are extracted from the ovaries are arrested at the prophase of the first meiotic division. At this stage of maturation, they are characterized by a large nucleus called the germinal vesicle. Meiosis resumption (maturation...