... Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. disease hydroxylation hypoxia nutrient sensing oxygenase post translational modification Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases (henceforth simplified...

... kinase (MAPK) nutrient sensing target of rapamycin (TOR) transceptor AA transporters are required to deliver AAs to intracellular AA sensors such as those of the TOR and GCN2 signalling pathways and may also operate subtly at various levels (as éminences grises , or ‘powers behind the throne...

... of a nutrient-sensing system in yeast that was responsive to extracellular amino acids [ 1 – 3 ]. In subsequent work, the primary sensor was found to be a plasma-membrane-localized complex comprising three core components, Ssy1, Ptr3 and Ssy5, and accordingly was dubbed the SPS-sensor [ 4 ]. The sensor...

... 2 diabetes and neurodegeneration. Recently, it has become clear that multiple types of local nutrient-sensing mechanisms have an impact on cellular insulin-sensitivity through the downstream kinase TOR (target of rapamycin). In vivo analysis in flies has surprisingly highlighted PATs ( p roton...

... diabetes Drosophila lipogenesis nutrient sensing Although altered PI3K/Akt signalling most obviously affects growth, other more subtle phenotypes are also observed. For example, photoreceptors mutant for the PI3K antagonist PTEN (phosphatase and tensin homologue deleted on chromosome 10; Figure...

.... diabetes fatty acid G-protein-coupled receptor GPR40 family nutrient sensing obesity Fatty acids serve vital functions as sources of energy, building materials for cellular structures, modulators of physiological responses, and in some cases, biomarkers for disease. SCFAs (short-chain fatty...

... (email [email protected] ). 17 9 2004 © 2005 The Biochemical Society 2005 amino acid nutrient sensing Saccharomyces cerevisiae Ssy1 transporter-like sensor In Saccharomyces cerevisiae , distinct mechanisms have evolved to sense the extracellular presence of amino acids...

... it is becoming evident that the gut epithelium senses and responds to luminal nutrients, little is known about the nature of the nutrient sensing molecule and the downstream cellular events. A prototype example is the modulation in the capacity of the gut to absorb monosaccharides via the intestinal luminal...