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Keywords: obesity
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Articles
Biochem Soc Trans (2022) 50 (1): 487–497.
Published: 07 January 2022
...Priyadarshni Patel; Jeganathan Ramesh Babu; Xu Wang; Thangiah Geetha Obesity is caused by a combination of hereditary and environmental factors. Despite extensive study, contemporary through diet, exercise, education, surgery, and pharmacological treatments, no effective long-term solution has been...
Articles
Biochem Soc Trans (2022) 50 (1): 447–457.
Published: 23 December 2021
...Le Zhao; Haili Yang; Xingchun Li; Yongju Zhao Obesity and its associated metabolic diseases, including diabetes, insulin resistance, and inflammation, are rapidly becoming a global health concern. Moreover, obese individuals are more likely to be infected with COVID-19. New research on adipose...
Articles
Biochem Soc Trans (2020) 48 (4): 1819–1828.
Published: 29 July 2020
...Megan Phillips; Jeganathan Ramesh Babu; Xu Wang; Thangiah Geetha In recent years, obesity has reached epidemic proportions globally and has become a major public health concern. The development of obesity is likely caused by several behavioral, environmental, and genetic factors. Genomic...
Articles
Biochem Soc Trans (2020) 48 (1): 291–300.
Published: 12 February 2020
... that are in dire need of new therapeutic targets. These include cancer, immunotherapy, diabetes, obesity, and Alzheimer's disease. In this mini-review, we will provide a brief overview of research in these areas that support targeting SHIP1, SHIP2 or both enzymes for therapeutic purposes. Correspondence...
Articles
Biochem Soc Trans (2019) 47 (1): 305–315.
Published: 30 January 2019
... and conservation with higher vertebrates, to perform phenotype-driven chemical and genetic screens. In this review, we describe how zebrafish have been used to reveal novel mechanisms by which metabolism regulates embryonic development, obesity, fatty liver disease and cancer. In addition, we will highlight how...
Articles
Biochem Soc Trans (2016) 44 (2): 638–644.
Published: 11 April 2016
... disease (CVD) and non-alcoholic fatty liver disease, as well as the development of insulin resistance and obesity. 1 To whom correspondence should be addressed (email jules.griffin@mrc-hnr.cam.ac.uk ; jlg40@cam.ac.uk ). 15 1 2016 © 2016 Authors; published by Portland Press Limited...
Articles
Biochem Soc Trans (2016) 44 (1): 293–298.
Published: 09 February 2016
... Authors; published by Portland Press Limited 2016 β-cell insulin lipid kinases nutrients obesity signalling CAPS calcium-dependent activator protein for secretion DAG diacylglycerol GSIS glucose-stimulated insulin secretion MAG mono-acyl-glycerol PI3K...
Articles
Biochem Soc Trans (2014) 42 (2): 419–424.
Published: 20 March 2014
..., HAGH (hydroxyacylglutathione hydrolase), has a regulatory p53-response element. Glo1 is linked to healthy aging, obesity, diabetes and diabetic complications, chronic renal disease, cardiovascular disease, other disorders and multidrug resistance in cancer chemotherapy. Mathematical modelling...
Articles
Biochem Soc Trans (2013) 41 (6): 1569–1576.
Published: 20 November 2013
... neuronal networks. In the present paper, we review molecular evidence suggesting that maternal nutrition and metabolism during pregnancy can affect the formation and function of the hippocampus and hypothalamus by altering endocannabinoid signalling such that neuropsychiatric diseases and obesity...
Articles
Biochem Soc Trans (2008) 36 (5): 905–908.
Published: 19 September 2008
... and death decisions of the pancreatic β-cell: the role of fatty acids Clin. Sci. 2007 112 27 42 7 Samaha F.F. Effect of very high-fat diets on body weight, lipoproteins, and glycemic status in the obese Curr. Atheroscler. Rep. 2005 7 412 420 8 Kusunoki M. Tsutsumi K...
Articles
Biochem Soc Trans (2008) 36 (5): 935–940.
Published: 19 September 2008
...Chong Yew Tan; Antonio Vidal-Puig The prevalence of obesity is increasing and with it the prevalence of associated metabolic complications. Precisely how obesity results in metabolic disturbances remains unclear. In the face of persistent positive caloric balance, it has been postulated...
Articles
Biochem Soc Trans (2008) 36 (3): 363–365.
Published: 21 May 2008
...Andreia S. Bernardo; Kevin Docherty Obesity is a metabolic disorder, which has been recognized as a global epidemic. It contributes to insulin resistance, the major cause of Type 2 diabetes, as well as to the development of other related diseases. Our basic premise is that a better understanding...
Articles
Biochem Soc Trans (2007) 35 (5): 1203–1204.
Published: 25 October 2007
...R.L. Cripps; Z.A. Archer; J.G. Mercer; S.E. Ozanne Obesity prevalence is increasing worldwide, leading to increased morbidity, mortality and health care costs due to its role as a key risk factor in many diseases. Early life growth and nutrition has been implicated in determining susceptibility...
Articles
Biochem Soc Trans (2007) 35 (3): 484–486.
Published: 22 May 2007
... © 2007 Biochemical Society 2007 apolipoprotein B48 (apoB48) cardiovascular disease chylomicron diabetes dyslipidaemia obesity Diet and Cardiovascular Health: Chylomicron Remnants and Their Emerging Roles in Vascular Dysfunction in Atherogenesis: Biochemical Society Focused...
Articles
Biochem Soc Trans (2007) 35 (3): 477–481.
Published: 22 May 2007
...R. Mangat; J. Su; P.G. Scott; J.C. Russell; D.F. Vine; S.D. Proctor Postprandial (PP) lipaemia is a significant contributor to the development of dyslipidaemia and cardiovascular disease (CVD). It is also evident that PP lipaemia is prevalent during conditions of obesity and insulin resistance (IR...
Articles
Biochem Soc Trans (2007) 35 (1): 33–36.
Published: 22 January 2007
..., and insulin resistance (basically, an impaired response to insulin in its target cell types). Type 2 diabetes occurs when both these phenotypes are combined ( Figure 1 ). The most common cause of insulin resistance is obesity (see, e.g., [ 5 ]). We have been studying Type 2 diabetes in my laboratory for 20...
Articles
Biochem Soc Trans (2006) 34 (5): 770–773.
Published: 25 October 2006
..., such as diabetes, obesity and the metabolic syndrome. 1 To whom correspondence should be addressed (email david.k.covington@gsk.com ). 21 6 2006 © 2006 The Biochemical Society 2006 Information Processing and Molecular Signalling: A Focus Topic at BioScience2006, held at SECC Glasgow, U.K...
Articles
Biochem Soc Trans (2005) 33 (5): 1049–1052.
Published: 26 October 2005
...S.W. Coppack This review gives a broad description of some of the changes in adipose tissue seen in obesity. There are multiple changes in adipose tissue in obesity: histological, neural and vascular, relating to lipid and carbo-hydrate metabolism and to adipose tissue's endocrine functions. Some...
Articles
Biochem Soc Trans (2005) 33 (2): 350–353.
Published: 01 April 2005
... in humans, monkeys and rodents. In humans, defects in aPKC in muscle are seen in Type II diabetes and its precursors, obesity, the obesity-associated polycystic ovary syndrome and impaired glucose tolerance. These defects in muscle aPKC activation are due to both impaired activation of insulin receptor...
Articles
Biochem Soc Trans (2005) 33 (1): 213–215.
Published: 01 February 2005
... C. Fillon S. Buck M. Schleicher E. Rodemann H.P. Knabbe C. Kandolf R. Lang F. Cell Physiol. Biochem. 2002 12 135 142 glucocorticoid hypertension metabolic syndrome obesity SGK1 serum The serum- and glucocorticoid-inducible kinase SGK1...
Articles
Biochem Soc Trans (2001) 29 (6): 791–797.
Published: 01 November 2001
... the adipose-specific promoter in aP2- Ucp 1 transgenic mice mitigated obesity induced by genetic or dietary factors. The obesity resistance, accompanied by mitochondrial uncoupling in adipocytes and increased energy expenditure, resulted from ectopic expression of UCP1 in white but not in brown fat. Probably...
Articles
Biochem Soc Trans (2001) 29 (6): 798–802.
Published: 01 November 2001
... rate mitochondria obesity thermogenesis UCP, uncoupling protein BAT, brown adipose tissue OGC, 2-oxoglutarate carrier CNS, central nervous system ROS, reactive oxygen species RT-PCR reverse transcriptase PCR SKM, skeletal muscle WT, wild-type Biochemical Society Transactions (200 I...
Articles
Biochem Soc Trans (2001) 29 (6): 785–791.
Published: 01 November 2001
... abdul.dulloo@unifr.ch ). 22 6 2001 © 2001 Biochemical Society 2001 fat oxidation obesity UCP2 UCP3 UCP, uncoupling protein BAT, brown adipose tissue FFA, free fatty acids FOG, fast oxidative-glycolytic SO, slow oxidative FG, fast glycolytic ROS, reactive oxygen species...