...Priyadarshni Patel; Jeganathan Ramesh Babu; Xu Wang; Thangiah Geetha Obesity is caused by a combination of hereditary and environmental factors. Despite extensive study, contemporary through diet, exercise, education, surgery, and pharmacological treatments, no effective long-term solution has been...

...Le Zhao; Haili Yang; Xingchun Li; Yongju Zhao Obesity and its associated metabolic diseases, including diabetes, insulin resistance, and inflammation, are rapidly becoming a global health concern. Moreover, obese individuals are more likely to be infected with COVID-19. New research on adipose...

...Megan Phillips; Jeganathan Ramesh Babu; Xu Wang; Thangiah Geetha In recent years, obesity has reached epidemic proportions globally and has become a major public health concern. The development of obesity is likely caused by several behavioral, environmental, and genetic factors. Genomic...

... that are in dire need of new therapeutic targets. These include cancer, immunotherapy, diabetes, obesity, and Alzheimer's disease. In this mini-review, we will provide a brief overview of research in these areas that support targeting SHIP1, SHIP2 or both enzymes for therapeutic purposes. Figure 1. SHIP...

... and conservation with higher vertebrates, to perform phenotype-driven chemical and genetic screens. In this review, we describe how zebrafish have been used to reveal novel mechanisms by which metabolism regulates embryonic development, obesity, fatty liver disease and cancer. In addition, we will highlight how...

... disease (CVD) and non-alcoholic fatty liver disease, as well as the development of insulin resistance and obesity. 1 To whom correspondence should be addressed (email [email protected] ; [email protected] ). 15 1 2016 © 2016 Authors; published by Portland Press Limited...

... [email protected] ). 30 11 2015 © 2016 Authors; published by Portland Press Limited 2016 β-cell insulin lipid kinases nutrients obesity signalling β-cells play an essential role in maintaining energy homoeostasis by secreting insulin in response to plasma glucose and other...

..., HAGH (hydroxyacylglutathione hydrolase), has a regulatory p53-response element. Glo1 is linked to healthy aging, obesity, diabetes and diabetic complications, chronic renal disease, cardiovascular disease, other disorders and multidrug resistance in cancer chemotherapy. Mathematical modelling...

... neuronal networks. In the present paper, we review molecular evidence suggesting that maternal nutrition and metabolism during pregnancy can affect the formation and function of the hippocampus and hypothalamus by altering endocannabinoid signalling such that neuropsychiatric diseases and obesity...

... and death decisions of the pancreatic β-cell: the role of fatty acids Clin. Sci. 2007 112 27 42 7 Samaha F.F. Effect of very high-fat diets on body weight, lipoproteins, and glycemic status in the obese Curr. Atheroscler. Rep. 2005 7 412 420 8 Kusunoki M. Tsutsumi K...

...Chong Yew Tan; Antonio Vidal-Puig The prevalence of obesity is increasing and with it the prevalence of associated metabolic complications. Precisely how obesity results in metabolic disturbances remains unclear. In the face of persistent positive caloric balance, it has been postulated...

...Andreia S. Bernardo; Kevin Docherty Obesity is a metabolic disorder, which has been recognized as a global epidemic. It contributes to insulin resistance, the major cause of Type 2 diabetes, as well as to the development of other related diseases. Our basic premise is that a better understanding...

...R.L. Cripps; Z.A. Archer; J.G. Mercer; S.E. Ozanne Obesity prevalence is increasing worldwide, leading to increased morbidity, mortality and health care costs due to its role as a key risk factor in many diseases. Early life growth and nutrition has been implicated in determining susceptibility...

... © 2007 Biochemical Society 2007 apolipoprotein B48 (apoB48) cardiovascular disease chylomicron diabetes dyslipidaemia obesity Diet and Cardiovascular Health: Chylomicron Remnants and Their Emerging Roles in Vascular Dysfunction in Atherogenesis: Biochemical Society Focused...

...R. Mangat; J. Su; P.G. Scott; J.C. Russell; D.F. Vine; S.D. Proctor Postprandial (PP) lipaemia is a significant contributor to the development of dyslipidaemia and cardiovascular disease (CVD). It is also evident that PP lipaemia is prevalent during conditions of obesity and insulin resistance (IR...

... 2007 The Biochemical Society 2007 diet insulin resistance leptin obesity peroxisome-proliferator-activated receptor γ (PPARγ) Type 2 diabetes One of the principal motivations underlying the biomedical science revolution of the late 20th and early 21st Centuries is the promise...

..., such as diabetes, obesity and the metabolic syndrome. 1 To whom correspondence should be addressed (email [email protected] ). 21 6 2006 © 2006 The Biochemical Society 2006 Information Processing and Molecular Signalling: A Focus Topic at BioScience2006, held at SECC Glasgow, U.K...

...S.W. Coppack This review gives a broad description of some of the changes in adipose tissue seen in obesity. There are multiple changes in adipose tissue in obesity: histological, neural and vascular, relating to lipid and carbo-hydrate metabolism and to adipose tissue's endocrine functions. Some...

... in humans, monkeys and rodents. In humans, defects in aPKC in muscle are seen in Type II diabetes and its precursors, obesity, the obesity-associated polycystic ovary syndrome and impaired glucose tolerance. These defects in muscle aPKC activation are due to both impaired activation of insulin receptor...

... of transport proteins. Among the most important future tasks is the search for proteins directly phosphorylated by SGK1. glucocorticoid hypertension metabolic syndrome obesity SGK1 serum The serum- and glucocorticoid-inducible kinase SGK1 was originally cloned as early gene induced...

...-mail [email protected] ). 22 6 2001 © 2001 Biochemical Society 2001 fat oxidation obesity UCP2 UCP3 UCP, uncoupling protein BAT, brown adipose tissue FFA, free fatty acids FOG, fast oxidative-glycolytic SO, slow oxidative FG, fast glycolytic ROS, reactive oxygen species...

... the adipose-specific promoter in aP2- Ucp 1 transgenic mice mitigated obesity induced by genetic or dietary factors. The obesity resistance, accompanied by mitochondrial uncoupling in adipocytes and increased energy expenditure, resulted from ectopic expression of UCP1 in white but not in brown fat. Probably...

... rate mitochondria obesity thermogenesis UCP, uncoupling protein BAT, brown adipose tissue OGC, 2-oxoglutarate carrier CNS, central nervous system ROS, reactive oxygen species RT-PCR reverse transcriptase PCR SKM, skeletal muscle WT, wild-type Biochemical Society Transactions (200 I...