..., allowing each elementary microfibril to associate into larger microfibrils. Not drawn to scale. The seemingly complex oligomeric arrangements of CESA proteins within the CSC are the result of individual interactions between subunits, such that CSC assembly can be interpreted as the sequential...

... that may be wasted simply by generating larger single polypeptide units, and allows new features such as cooperativity to emerge. Taking inspiration from nature, protein designers and engineers are now building artificial oligomeric complexes using a variety of approaches to generate new and useful...

... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . allosteric regulation HD domain HIV hydrolase oligomerization SAMHD1 Sterile-α-motif and HD domain containing...

... protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies on UapA, a nucleobase ascorbate transporter, from Aspergillus nidulans , have revealed both that dimerization of this protein is essential for correct trafficking...

... Society 2015 Ca 2+ release channel excitation–contraction coupling inter-domain interactions oligomerization pathophysiology ryanodine receptor Several studies have also indicated that N-terminal/central domain unzipping underlies channel dysfunction and diastolic SR Ca 2+ leak...

...Sarah R. Needham; Laura C. Zanetti-Domingues; Michael Hirsch; Daniel J. Rolfe; Christopher J. Tynan; Selene K. Roberts; Marisa L. Martin-Fernandez; David T. Clarke Dimerization and higher-order oligomerization are believed to play an important role in the activation of the EGFR (epidermal growth...

... that were not clearly visible before. The application of the PALM technique to study the plasma membrane organization of signalling molecules, such as GPCRs, has successfully determined the oligomeric fraction of β 2 -adrenergic receptor in cardiomyocytes cells, which is dependent on actin integrity...

... to the study of this RNR have revealed the importance of oligomeric state to overall enzyme activity and suggest that unprecedented subunit configurations are in play. Although it has been five decades since the isolation of nucleotide reductase activity in extracts of E. coli , this prototypical RNR continues...

...Tina Perica; Joseph A. Marsh; Filipa L. Sousa; Eviatar Natan; Lucy J. Colwell; Sebastian E. Ahnert; Sarah A. Teichmann All proteins require physical interactions with other proteins in order to perform their functions. Most of them oligomerize into homomers, and a vast majority of these homomers...

... These authors contributed equally to this work. 2 To whom correspondence should be addressed (email [email protected] ). 3 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 CD81 Claudin-1 hepatitis C virus (HCV) oligomerization tetraspanin...

...-driven assembly of this oligomeric complex, in which NorR apparently forms a DNA-bound hexamer in the absence of NO, provides a ‘poised’ system for transcriptional activation that can respond rapidly to nitrosative stress. 1 To whom correspondence should be addressed: (email matt.bush...

...-frankfurt.mpg.de ). 20 9 2005 © 2006 The Biochemical Society 2006 collybistin gephyrin glycine receptor oligomerization splicing vasodilator-stimulated phosphoprotein (VASP) Gephyrin is a ubiquitously expressed protein with an apparent molecular mass of approx. 93 kDa. In neurons...

...-treated cells. 1 To whom correspondence should be addressed (email [email protected] ). 8 7 2004 © 2004 The Biochemical Society 2004 cholesterol glycosylphosphatidylinositol anchor lipid raft Listeria monocytogenes listeriolysin O oligomerization Fifteen years after...

... assay, we also demonstrated that the interaction with NMDAR abolishes agonist-mediated D 1 R sequestration, indicating that oligomerization with NMDAR could represent a novel regulatory mechanism modulating D 1 R cellular trafficking and desensitization. 1 To whom correspondence should...

..., the two proteins associated into homodimers and homotrimers respectively. Moreover, studies using the TOXCAT assay system confirmed that the αIIb and β3 transmembrane domains can self-associate in biological cell membranes. Transmembrane domain-mediated homo-oligomerization provides a plausible structural...

... evidence for the oligomerization of the p14ARF tumour suppressor and Mdm2 inhibitor in response to oxidative stress. 1 e-mail [email protected] 678th Meeting of the Biochemical Society, held at Imperial College, London, 16–18 December 2002 15 January 2003 Copyright 2003...

...-protein long-term potentiation neurotoxicity oligomerization Aβ, amyloid-β peptide AD, Alzheimer's disease APP, amyloid-β precursor protein CM, conditioned medium IDE, insulin-degrading enzyme LTP, long-term potentiation Biochemical Society Transactions (2002) Volume 30, part 4 ~ Amyloid...