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Keywords: on-target toxicity
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Articles
Treatment of metastatic renal cell carcinoma (mRCC) with CAIX CAR-engineered T-cells–a completed study overview
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 951–959.
Published: 09 June 2016
... of treatment in four out of eight patients (cohort 1+2). Examination of liver biopsies revealed T-cell infiltration around bile ducts and CAIX expression on bile duct epithelium, adding to the notion of on-target toxicity. No such toxicities were observed in four patients that were pretreated with G250 mAb...
