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Keywords: oncogene
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Articles
Biochem Soc Trans (2017) 45 (4): 855–870.
Published: 03 July 2017
... information, analytical reagents and model systems available regarding normal and oncogenic HGF/Met signaling will continue to be invaluable in meeting these challenges and moving expeditiously toward more effective cancer treatment. Correspondence: Donald P. Bottaro ( dbottaro@helix.nih.gov...
Articles
Biochem Soc Trans (2016) 44 (3): 925–931.
Published: 09 June 2016
..., and the impact on the pathways in which that protein is involved. In this paper we examine the mutation patterns observed in oncogenes and tumour suppressors, and discuss different approaches that have been developed to identify driver mutations within cancers that contribute to the disease progress. We also...
Includes: Supplementary data
Articles
Biochem Soc Trans (2013) 41 (4): 1029–1036.
Published: 18 July 2013
... E. Parikh C. Durinck S. Chaudhuri S. Pujara K. Guillory J. Edgar K.A. Oncogenic ERBB3 mutations in human cancers Cancer Cell 2013 23 603 617 30 Baselga J. Swain S.M. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3 Nat. Rev. Cancer...
Articles
Biochem Soc Trans (2012) 40 (1): 251–256.
Published: 19 January 2012
... of tumour cell invasion and migration. Several oncogenes can stimulate ERK5 activity, and protein levels are increased by a novel amplification at chromosome locus 17p11 and by down-regulation of the microRNAs miR-143 and miR-145 . Together, these finding underscore the case for further investigation...
Articles
Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
... in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult...
Articles
Biochem Soc Trans (2008) 36 (4): 599–602.
Published: 22 July 2008
...Lezanne Ooi; Ian C. Wood Many human diseases are the result of inappropriate changes in gene expression resulting in deleterious phenotypes of specific cells. For example, loss of expression of tumour suppressors and/or ectopic expression of oncogenes underlie many cancers, a switch from an adult...
Articles
Biochem Soc Trans (2005) 33 (2): 343–345.
Published: 01 April 2005
... The Biochemical Society 2005 glycogen inhibitor insulin kinase oncogene phosphatase There are several reasons why phosphorylation is a major method of control in biological systems, and a very attractive target for therapeutic intervention [ 1 ]. Phosphorylation is one of the most ubiquitous...