... protein). Taken together, these studies suggest that HtrA1 may be a novel therapeutic target for several diseases. © The Authors Journal compilation © 2007 Biochemical Society 2007 differentiation high-temperature requirement protein A1 (HtrA1) mineralization osteoarthritis osteoblast...

... controlled by osteoclasts, which are monocytic in origin and resorb existing bone, and BMSC (bone marrow stromal cell)-derived osteoblasts, which synthesize new bone. Interactions between cells of osteoclast/osteoblast lineages occur at several levels but most importantly recruitment and activation...