...Akihiko Nunomura; Hyoung-gon Lee; Xiongwei Zhu; George Perry Unlike DNA, oxidative damage to RNA has received little attention presumably due to the assumed transient nature of RNA. However, RNAs including mRNA can persist for several hours to days in certain tissues and are demonstrated to sustain...

...Michael P. Murphy Mitochondrial oxidative damage has long been known to contribute to damage in conditions such as ischaemia–reperfusion (IR) injury in heart attack. Over the past years, we have developed a series of mitochondria-targeted compounds designed to ameliorate or determine how...

... on Oxidative DNA Damage has concluded that the true levels of the most widely studied lesion, 8-oxodG (8-oxo-7,8-dihydro-2′-deoxyguanosine), in cellular DNA is between 0.5 and 5 lesions per 10 6 dG bases. Base excision repair of oxidative damage to DNA can be assessed by nicking assays based...

...B. Halliwell The terms ‘antioxidant’, ‘oxidative stress’ and ‘oxidative damage’ are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using...

... In vitro and in vivo effects of oxidative damage to deoxyguanosine M.M. Greenberg1 Department of Chemistry, Johns Hopkins University, 3400 North Charles St, Baltimore, MD 21218, U.S.A. Abstract Biochemical, biophysical and biological studies of oligonucleotides containing lesions at defined sites provide...

...-stimulated proteolysis of CopZ appears to play an important role in copper homoeostasis by E. hirae. 1 E-mail [email protected] 10 3 2002 © 2002 Biochemical Society 2002 cop operon CopZ Enterococcus hirae metallochaperone oxidative damage Biometals 2002...