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Keywords: oxidative stress
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Articles
Therapeutic exploitation of ferroptosis
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 693–706.
Published: 17 April 2024
... Society 2024 cancer cell death ferroptosis ischaemia-reperfusion injury lipid peroxidation oxidative stress Approximately 2.4 billion years ago, ‘The Great Oxygenation event’ changed the earth's atmospheric landscape. The significant increase in atmospheric oxygen levels introduced new...
Articles
Type III intermediate filaments in redox interplay: key role of the conserved cysteine residue
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 849–860.
Published: 07 March 2024
... and appears to play a key role in the ability of the filament network to respond to oxidative stress. Current structural models and experimental evidence indicate that this cysteine residue may occupy a strategic position in the filaments in such a way that perturbations at this site, due to chemical...
Articles
Opeyemi Stella Ademowo, Olubukola Oyebode, Roshita Edward, Myra E. Conway, Helen R. Griffiths, Irundika H.K. Dias
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 65–74.
Published: 22 February 2024
...Opeyemi Stella Ademowo; Olubukola Oyebode; Roshita Edward; Myra E. Conway; Helen R. Griffiths; Irundika H.K. Dias Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS...
Articles
RNA-binding proteins that preferentially interact with 8-oxoG-modified RNAs: our current understanding
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 111–122.
Published: 04 January 2024
...Kathleen E. Taylor; Lucas G. Miller; Lydia M. Contreras Cells encounter a variety of stresses throughout their lifetimes. Oxidative stress can occur via a myriad of factors, including exposure to chemical toxins or UV light. Importantly, these stressors induce chemical changes (e.g. chemical...
Articles
Caveolae and the oxidative stress response
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1377–1385.
Published: 30 May 2023
...Yeping Wu; Ye-Wheen Lim; Robert G. Parton Oxidative stress is a feature of many disease conditions. Oxidative stress can activate a number of cellular pathways leading to cell death, including a distinct iron-dependent pathway involving lipid peroxidation, termed ferroptosis, but cells have evolved...
Articles
Redox-regulated chaperones in cell stress responses
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1169–1177.
Published: 04 May 2023
...Kathrin Ulrich Proteostasis and redox homeostasis are tightly interconnected and most protein quality control pathways are under direct redox regulation which allow cells to immediately respond to oxidative stress conditions. The activation of ATP-independent chaperones serves as a first line...
Articles
Cardiotoxicity of pyrethroids: molecular mechanisms and therapeutic options for acute and long-term toxicity
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1737–1751.
Published: 16 November 2022
... of the late sodium current (INaL), which impairs the action potential waveform and can cause severe cardiac arrhythmias. Moreover, long-term, low-dose exposure to PY displays oxidative stress in the heart, which could induce tissue remodeling and impairment. Isolated and preliminary evidence supports...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2189–2198.
Published: 19 October 2021
... metabolic reprogramming oxidative stress In 1836, Samuel Baup discovered an unknown product following the thermal decomposition of citric acid [ 1 ]. Four years later, Gustav Crasso synthesised the same compound by decarboxylation of cis -aconitate naming it itaconate — an anagram of aconitate [ 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1295–1303.
Published: 17 November 2017
... and oxidative stress are implicated in many disorders. That these pathological processes can influence each other both up- and downstream makes for a complicated picture, but means that successfully targeting one area may have an effect on others. This targeting requires an understanding of the mechanisms...
Articles
Theresia A. Schaedler, Belinda Faust, Chitra A. Shintre, Elisabeth P. Carpenter, Vasundara Srinivasan, Hendrik W. van Veen, Janneke Balk
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 943–951.
Published: 09 October 2015
... of the mitochondria, whereas ABCB10 is involved in haem biosynthesis. They also play a role in preventing oxidative stress. Mutations in ABCB6 and ABCB7 have been linked to human disease. Recent crystal structures of yeast Atm1 and human ABCB10 have been key to identifying substrate-binding sites and transport...
Articles
Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathway
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 632–638.
Published: 03 August 2015
... (reduction-oxidation) homoeostasis using a previously unrecognized NADPH-independent source of reducing power fuelled by dietary methionine. The NADPH-dependent systems are robustly redundant in liver, such that disruption of either TrxR1 or GR alone does not cause oxidative stress. However, disruption...
Articles
Frequency modulated translocational oscillations of Nrf2, a transcription factor functioning like a wireless sensor
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 669–673.
Published: 03 August 2015
.... Holtzclaw W.D. Kang M. Kobayashi A. Yamamoto M. Kensler T.W. Talalay P. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers Proc. Natl. Acad. Sci. U.S.A. 2004 101 2040 2045 10.1073...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 663–668.
Published: 03 August 2015
... be addressed (email [email protected] ) . 19 2 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution License 3.0 . disease tolerance infection Nrf2 oxidative stress tissue damage...
Articles
Redox-based regulation of neural stem cell function and Nrf2
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
Dysregulation of the Keap1–Nrf2 pathway in cancer
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 645–649.
Published: 03 August 2015
... Authors; published by Portland Press Limited 2015 cancer genome Kelch-like ECH-associated protein 1 (Keap1) nuclear factor E2-related factor 2 (Nrf2) oxidative stress The Cancer Genome Atlas (TCGA) Oxidative stress, an imbalance between the production and disposal of reactive oxygen...
Articles
The role of oxidative stress in the cardiovascular actions of particulate air pollution
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1006–1011.
Published: 11 August 2014
... thrombosis and impair fibrinolysis, accelerate the development of atherosclerosis, increase the extent of myocardial ischaemia, and increase susceptibility to myocardial infarction. The pathways underlying these effects are complex and poorly understood; however, particulate-induced oxidative stress...
Articles
Aberrant redox homoeostasis and mitochondrial dysfunction in Rett syndrome
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 959–964.
Published: 11 August 2014
... physiological cell function, it is not surprising that disturbed redox balance is considered to be causally linked to neuropathology. There is convincing evidence that also RTT is associated with redox imbalance and oxidative stress [ 24 , 39 ] ( Figure 1 ). In patients, lowered blood serum levels...
Articles
About the dangers, costs and benefits of living an aerobic lifestyle
Available to PurchaseDaniela Knoefler, Lars I.O. Leichert, Maike Thamsen, Claudia M. Cremers, Dana Reichmann, Michael J. Gray, Wei-Yun Wholey, Ursula Jakob
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 917–921.
Published: 11 August 2014
..., yet its mode of action has remained enigmatic. We have discovered that, under bleach-like stress, bacteria re-direct large amounts of ATP into long chains of polyP [ 37 ]. Our data suggest that this reallocation of ATP is largely responsible for the observed oxidative stress-mediated depletion...
Articles
Ultra-endurance exercise: unanswered questions in redox biology and immunology
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
.... The majority of studies discussed examine continuous ultra-endurance exercise that it is not separated by periods of recovery (i.e. sleep). Although analysis of some oxidative stress biomarkers suggests an additive effect of repeated ultra-endurance exercise, analysis of other biomarkers suggests...
Articles
Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 928–933.
Published: 11 August 2014
... diabetes endothelial cell glucose oxidative stress Diabetes and diabetes-related disease are at epidemic levels. Although T1DM (Type 1 diabetes mellitus), a disease principally of autoimmune origin, remains a significant and pernicious problem, the massive global rise in morbidity and mortality...
Articles
Hypercholesterolaemia-induced oxidative stress at the blood–brain barrier
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1001–1005.
Published: 11 August 2014
..., during oxidative stress, plasma oxycholesterols could have damaging effects on BBB (blood–brain barrier) function and consequently on neuronal cells. Cholesterol-lowering drugs such as statins may prevent the modifications to LDL in mid-life and might show beneficial effects in later life. 1...
Articles
Dicarbonyl stress and glyoxalases in ovarian function
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 433–438.
Published: 20 March 2014
... with their receptors results in generation of oxidative stress and activation of redox-sensitive transcription factors such as NF-κB (nuclear factor κB) [ 32 ]. Malicková et al. [ 33 ] reported that the FF concentration of sRAGE (soluble RAGE), a circulating isoform of RAGE that can neutralize the ligand-mediated...
Articles
Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... the Lifespan: Translational Neuroscience from Molecule to Man: An Independent Meeting held at University College Cork, Ireland, 12–13 September 2013. Organized and Edited by Eoin Fleming (University College Cork, Ireland). memory neurodegeneration oxidative stress synaptic plasticity...
Articles
Assay of methylglyoxal-derived protein and nucleotide AGEs
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 511–517.
Published: 20 March 2014
..., oxidation and nitration and DNA glycation and oxidation represent imperfections of physiological systems, and these processes increase in hyperglycaemia and metabolic stress conditions, e.g. dicarbonyl stress, oxidative stress and nitrosative stress. These abnormal metabolic states are widely implicated...
Articles
Regulating the level of intracellular hydrogen peroxide: the role of peroxiredoxin IV
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 42–46.
Published: 23 January 2014
...Rachel E. Martin; Zhenbo Cao; Neil J. Bulleid Hydrogen peroxide (H 2 O 2 ) can act as a signalling molecule affecting the cell cycle as well as contributing towards the oxidative stress response. The primary target of this molecule is oxidation-sensitive cysteine residues in proteins...
Articles
Insight into a neuron's preferential susceptibility to oxidative stress
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
...Karen F.S. Bell Neurons are more vulnerable to oxidative stress than astrocytes, the reasons for which have yet to be fully elucidated. Understanding the cellular and molecular mechanisms which contribute to this enhanced vulnerability is key to efforts aimed at ameliorating neuronal health...
Articles
The nuclear envelope and its involvement in cellular stress responses
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1795–1798.
Published: 21 November 2011
... a role for CCTα, the nucleoplasmic reticulum and lamin A/C in differentiation of MDCK cells under hypertonic conditions [ 25 ] and recovery from osmotic stress. In addition to the above, oxidative stress triggers a response that affects transport into and out of the nucleus. Mild oxidative stress...
Articles
Mechanisms and consequences of oxidative damage to extracellular matrix
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1279–1287.
Published: 21 September 2011
... protected against oxidation than intracellular sites in terms of the presence of both antioxidants (low molecular mass and enzymatic) and repair enzymes. The extracellular compartment may therefore be subject to greater oxidative stress, marked alterations in redox balance and an accumulation of damage due...
Articles
Redox signalling via the cellular thiolstat
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1247–1253.
Published: 21 September 2011
... Biochemical Society 2011 cysteine oxidative stress redox signalling S-thiolation thiolstat Among the various intracellular signalling networks operational within the living cell, the ones based on phosphorylation and dephosphorylation may be the best known and understood. Nonetheless, other...
Articles
Measurement of exercise-induced oxidative stress in lymphocytes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1299–1304.
Published: 21 September 2011
...James E. Turner; Jos A. Bosch; Sarah Aldred Vigorous exercise is associated with oxidative stress, a state that involves modifications to bodily molecules due to release of pro-oxidant species. Assessment of such modifications provides non-specific measures of oxidative stress in human tissues...
Articles
Mitochondrial (‘mild’) uncoupling and ROS production: physiologically relevant or not?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email [email protected] ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
Articles
Role of oxidative stress and antioxidant enzymes in Crohn's disease
Available to PurchaseMarisa Iborra, Inés Moret, Francisco Rausell, Guillermo Bastida, Mariam Aguas, Elena Cerrillo, Pilar Nos, Belén Beltrán
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 1102–1106.
Published: 20 July 2011
...Marisa Iborra; Inés Moret; Francisco Rausell; Guillermo Bastida; Mariam Aguas; Elena Cerrillo; Pilar Nos; Belén Beltrán There is increasing interest in oxidative stress being a potential aetiological factor and/or a triggering factor in Crohn's disease, rather than a concomitant occurrence during...
Articles
Gene expression study of the flavodi-iron proteins from the cyanobacterium Synechocystis sp. PCC6803
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 216–218.
Published: 19 January 2011
...) nitrosative stress oxidative stress Synechocystis sp. PCC6803 The FDPs (flavodi-iron proteins), previously named A-type flavoproteins, are a family of soluble and modular enzymes with a two-domain conserved core constituted by a metallo-β-lactamase-like domain, at the N-terminus, linked...
Articles
Coupling of the NMDA receptor to neuroprotective and neurodestructive events
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1147–1160.
Published: 19 November 2009
... the neuroprotective and neurodestructive effects of NMDA receptor activity, as well as the factors that determine whether an episode of NMDA receptor activity is harmful or beneficial. It is becoming apparent that oxidative stress plays a role in promoting neuronal death in response to both hyper- and hypo-activity...
Articles
Spare respiratory capacity, oxidative stress and excitotoxicity
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
...David G. Nicholls Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress...
Articles
Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 819–823.
Published: 22 July 2009
... in the lungs, and COPD is also associated with features of accelerated aging in other organs, such as the cardiovascular and musculoskeletal systems. Cigarette smoke and other oxidative stresses result in cellular senescence and accelerate lung aging. There is also evidence that anti-aging molecules...
Articles
Iron and calcium in the central nervous system: a close relationship in health and sickness
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1309–1312.
Published: 19 November 2008
...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...
Articles
Iron chelation as a potential therapy for neurodegenerative disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1304–1308.
Published: 19 November 2008
...Robert C. Hider; Yongmin Ma; Francisco Molina-Holgado; Alessandra Gaeta; Sourav Roy Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated...
Articles
Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease
Available to PurchaseJack T. Rogers, Ashley I. Bush, Hyan-Hee Cho, Deborah H. Smith, Andrew M. Thomson, Avi L. Friedlich, Debomoy K. Lahiri, Peter J. Leedman, Xudong Huang, Catherine M. Cahill
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1282–1287.
Published: 19 November 2008
... is cleaved in a non-amyloidogenic pathway within its Aβ domain to release the neuroprotective APP ectodomain, APP(s). To adapt and counteract metal-catalysed oxidative stress, as during reperfusion from stroke, iron and cytokines induce the translation of both APP and ferritin (an iron storage protein...
Articles
Role of transition metals in the pathogenesis of amyotrophic lateral sclerosis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1322–1328.
Published: 19 November 2008
... 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyotrophic lateral sclerosis (ALS) Cu,Zn-superoxide dismutase (SOD1) oxidative stress protein aggregation transition metal With an incidence of 1–2 per 100000 individuals per year, ALS (amyotrophic lateral...
Articles
Metal-dependent generation of reactive oxygen species from amyloid proteins implicated in neurodegenerative disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1293–1298.
Published: 19 November 2008
... 29 Barnham K.J. Masters C.L. Bush A.I. Neurodegenerative diseases and oxidative stress Nat. Rev. Drug Discov. 2004 3 205 214 30 Sayre L.M. Smith M.A. Perry G. Chemistry and biochemistry of oxidative stress in neurodegenerative disease Curr. Med. Chem. 2001...
Articles
Key issues in F 2 -isoprostane analysis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1060–1065.
Published: 19 September 2008
...Jaffar Nourooz-Zadeh A large body of evidence indicates that measurement of F 2 -isoprostanes, specific prostaglandin F 2 -like compounds derived from the non-enzymatic peroxidation of arachidonic acid, is a reliable biomarker of oxidant stress in the human body. Since the discovery of F 2...
Articles
Mass spectrometry approaches for vitamin E research
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1066–1070.
Published: 19 September 2008
... to monitor vitamin E status and its interactions, including the use of stable-isotope-labelled vitamin E and metabonomics, are highlighted. Specifically, stable-isotope studies have been used to monitor vitamin E absorption, hepatic processing and lipoprotein transport. As oxidative stress may influence...
Articles
The production of reactive oxygen species by complex I
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
...Judy Hirst; Martin S. King; Kenneth R. Pryde ROS (reactive oxygen species) are considered to be a major cause of cellular oxidative stress, linked to neuromuscular diseases and aging. Complex I (NADH:ubiquinone oxidoreductase) is one of the main contributors to superoxide production by mitochondria...
Articles
High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function
Available to PurchaseStephen Barnes, Erin M. Shonsey, Shannon M. Eliuk, David Stella, Kerri Barrett, Om P. Srivastava, Helen Kim, Matthew B. Renfrow
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1037–1044.
Published: 19 September 2008
... Sciences, P.O. Box 3510, Auburn, AL 36830-3510, U.S.A. 29 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 It has long been appreciated that oxidative stress is part of the aetiology of many chronic diseases, including cardiovascular disease, diabetes...
Articles
Mass spectrometric analysis of HOCl- and free-radical-induced damage to lipids and proteins
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1077–1082.
Published: 19 September 2008
... oxidation products may offer more potential as biomarkers of MPO- and HOCl-induced damage. biomarker chlorohydrin chlorotyrosine free radical oxidative stress precursor-ion scanning HOCl is generated under inflammatory conditions when phagocytes are activated and MPO is released...
Articles
Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1045–1050.
Published: 19 September 2008
... and produce life extension in the nematode Caenorhabditis elegans . This suggests that dicarbonyl glycation damage to the mitochondrial proteome may be a preceding event to mitochondrial dysfunction leading to oxidative stress. Future research will address the functional charges in mitochondrial proteins...
Articles
The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 930–934.
Published: 19 September 2008
... are currently envisaged. Among them, lipids and oxidative stress are considered as toxic candidates for the β-cell. The cellular link between fatty acids and ROS (reactive oxygen species) is essentially the mitochondrion, a key organelle for the control of insulin secretion. Mitochondria are the main source...
Articles
Oxidative stress: the vulnerable β-cell
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 343–347.
Published: 21 May 2008
..., 30623 Hannover, Germany. 13 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 diabetes free radical oxidative stress pancreatic β-cell death reactive nitrogen species reactive oxygen species The pancreatic β-cell is in an extraordinary situation...
Articles
Do mitochondrial DNA mutations have a role in neurodegenerative disease?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1232–1235.
Published: 25 October 2007
... compilation © 2007 Biochemical Society 2007 mitochondrial DNA (mtDNA) mitochondrial DNA mutation mitochondrial dysfunction neurodegenerative disease oxidative stress Parkinson's disease The vast majority of a cell's energy is produced by mitochondria in a process of OXPHOS (oxidative...
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