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Keywords: oxidative stress
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 693–706.
Published: 17 April 2024
... ) * Shared first authorship. 18 1 2024 21 3 2024 2 4 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 cancer cell death ferroptosis ischaemia-reperfusion injury lipid peroxidation oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 849–860.
Published: 07 March 2024
... and appears to play a key role in the ability of the filament network to respond to oxidative stress. Current structural models and experimental evidence indicate that this cysteine residue may occupy a strategic position in the filaments in such a way that perturbations at this site, due to chemical...
Articles
Opeyemi Stella Ademowo, Olubukola Oyebode, Roshita Edward, Myra E. Conway, Helen R. Griffiths, Irundika H.K. Dias
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 65–74.
Published: 22 February 2024
...Opeyemi Stella Ademowo; Olubukola Oyebode; Roshita Edward; Myra E. Conway; Helen R. Griffiths; Irundika H.K. Dias Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 111–122.
Published: 04 January 2024
...Kathleen E. Taylor; Lucas G. Miller; Lydia M. Contreras Cells encounter a variety of stresses throughout their lifetimes. Oxidative stress can occur via a myriad of factors, including exposure to chemical toxins or UV light. Importantly, these stressors induce chemical changes (e.g. chemical...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1377–1385.
Published: 30 May 2023
...Yeping Wu; Ye-Wheen Lim; Robert G. Parton Oxidative stress is a feature of many disease conditions. Oxidative stress can activate a number of cellular pathways leading to cell death, including a distinct iron-dependent pathway involving lipid peroxidation, termed ferroptosis, but cells have evolved...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1169–1177.
Published: 04 May 2023
...Kathrin Ulrich Proteostasis and redox homeostasis are tightly interconnected and most protein quality control pathways are under direct redox regulation which allow cells to immediately respond to oxidative stress conditions. The activation of ATP-independent chaperones serves as a first line...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1737–1751.
Published: 16 November 2022
... of the late sodium current (INaL), which impairs the action potential waveform and can cause severe cardiac arrhythmias. Moreover, long-term, low-dose exposure to PY displays oxidative stress in the heart, which could induce tissue remodeling and impairment. Isolated and preliminary evidence supports...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2189–2198.
Published: 19 October 2021
... 28 9 2021 cardiovascular disease immunometabolism inflammation itaconate metabolic reprogramming oxidative stress In 1836, Samuel Baup discovered an unknown product following the thermal decomposition of citric acid [ 1 ]. Four years later, Gustav Crasso synthesised the same...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1295–1303.
Published: 17 November 2017
... and oxidative stress are implicated in many disorders. That these pathological processes can influence each other both up- and downstream makes for a complicated picture, but means that successfully targeting one area may have an effect on others. This targeting requires an understanding of the mechanisms...
Articles
Theresia A. Schaedler, Belinda Faust, Chitra A. Shintre, Elisabeth P. Carpenter, Vasundara Srinivasan, Hendrik W. van Veen, Janneke Balk
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 943–951.
Published: 09 October 2015
... of the mitochondria, whereas ABCB10 is involved in haem biosynthesis. They also play a role in preventing oxidative stress. Mutations in ABCB6 and ABCB7 have been linked to human disease. Recent crystal structures of yeast Atm1 and human ABCB10 have been key to identifying substrate-binding sites and transport...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 632–638.
Published: 03 August 2015
... (reduction-oxidation) homoeostasis using a previously unrecognized NADPH-independent source of reducing power fuelled by dietary methionine. The NADPH-dependent systems are robustly redundant in liver, such that disruption of either TrxR1 or GR alone does not cause oxidative stress. However, disruption...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 669–673.
Published: 03 August 2015
... chemoprotection oxidative stress oscillation Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the cellular expression of a battery of protective genes countering oxidative stress, toxic substances, lipid peroxidation, inflammation, metabolic dysfunction and aging [ 1 – 3 ]. It senses...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 663–668.
Published: 03 August 2015
... be addressed (email [email protected] ) . 19 2 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution License 3.0 . disease tolerance infection Nrf2 oxidative stress tissue damage...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 645–649.
Published: 03 August 2015
... Authors; published by Portland Press Limited 2015 cancer genome Kelch-like ECH-associated protein 1 (Keap1) nuclear factor E2-related factor 2 (Nrf2) oxidative stress The Cancer Genome Atlas (TCGA) Oxidative stress, an imbalance between the production and disposal of reactive oxygen...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
... analysis of some oxidative stress biomarkers suggests an additive effect of repeated ultra-endurance exercise, analysis of other biomarkers suggests that clearance or repair processes can be initiated between sampling points and bouts of exercise [ 4 ]. Thus studies investigating multi-day events including...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1001–1005.
Published: 11 August 2014
..., during oxidative stress, plasma oxycholesterols could have damaging effects on BBB (blood–brain barrier) function and consequently on neuronal cells. Cholesterol-lowering drugs such as statins may prevent the modifications to LDL in mid-life and might show beneficial effects in later life. 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1006–1011.
Published: 11 August 2014
... thrombosis and impair fibrinolysis, accelerate the development of atherosclerosis, increase the extent of myocardial ischaemia, and increase susceptibility to myocardial infarction. The pathways underlying these effects are complex and poorly understood; however, particulate-induced oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 959–964.
Published: 11 August 2014
... disease oxidative stress reactive oxygen species (ROS) redox imaging RTT (Rett syndrome) was initially described in 1966 as an “unusual brain atrophy syndrome” [ 1 , 2 ]. It primarily affects girls with a prevalence of 1:10000–15000, and is associated with severe cognitive impairment. Typically...
Articles
Daniela Knoefler, Lars I.O. Leichert, Maike Thamsen, Claudia M. Cremers, Dana Reichmann, Michael J. Gray, Wei-Yun Wholey, Ursula Jakob
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 917–921.
Published: 11 August 2014
... The Authors Journal compilation © 2014 Biochemical Society 2014 aging chaperone host defence oxidative stress protein unfolding Living an aerobic lifestyle is treacherous. ROS (reactive oxygen species), including peroxide, superoxide and hydroxyl radicals, are constantly produced...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 928–933.
Published: 11 August 2014
..., is rapidly deactivated by superoxide radicals. 1 To whom correspondence should be addressed (email [email protected] ). 30 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cardiovascular disease diabetes endothelial cell glucose oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 511–517.
Published: 20 March 2014
... methylglyoxal 3-nitrotyrosine oxidative stress 8-oxodeoxyguanosine Proteins in physiological systems undergo continual spontaneous modification by glycating agents such as glucose, MG (methylglyoxal) and others forming glycation adducts. Glycation adducts are classified into two groups: early...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... improvement in the Mattis DRS-2 cognitive score, suggesting that the drug has beneficial effects on cognition and memory [ 62 ]. This result greatly supports the hypothesis that GLP-1 receptor agonists may be a novel effective treatment for AD as well. memory neurodegeneration oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 433–438.
Published: 20 March 2014
... fertility. advanced glycation end-product (AGE) female fertility oocyte aging ovarian aging oxidative stress polycystic ovarian syndrome (PCOS) Although reproductive success is related to positive outcome of intrauterine fetal growth, it begins in the ovary with the production...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 42–46.
Published: 23 January 2014
...Rachel E. Martin; Zhenbo Cao; Neil J. Bulleid Hydrogen peroxide (H 2 O 2 ) can act as a signalling molecule affecting the cell cycle as well as contributing towards the oxidative stress response. The primary target of this molecule is oxidation-sensitive cysteine residues in proteins...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
...Karen F.S. Bell Neurons are more vulnerable to oxidative stress than astrocytes, the reasons for which have yet to be fully elucidated. Understanding the cellular and molecular mechanisms which contribute to this enhanced vulnerability is key to efforts aimed at ameliorating neuronal health...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1795–1798.
Published: 21 November 2011
... Journal compilation © 2011 Biochemical Society 2011 cellular stress DNA damage heat shock nuclear envelope oxidative stress The NE (nuclear envelope) is a structure composed of the outer and inner nuclear membranes, an inter-membrane space bridged by protein complexes, and an underlying...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1279–1287.
Published: 21 September 2011
... protected against oxidation than intracellular sites in terms of the presence of both antioxidants (low molecular mass and enzymatic) and repair enzymes. The extracellular compartment may therefore be subject to greater oxidative stress, marked alterations in redox balance and an accumulation of damage due...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1247–1253.
Published: 21 September 2011
..., hydride transfer, nucleophilic exchange reactions). Aspects of the resulting cysteine-centred cellular redox control system, which is frequently involved in OS (oxidative stress) responses and ‘life and death’ decisions, are slowly emerging ( Figure 1 ). Nonetheless, little is known about the proteins...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1299–1304.
Published: 21 September 2011
...James E. Turner; Jos A. Bosch; Sarah Aldred Vigorous exercise is associated with oxidative stress, a state that involves modifications to bodily molecules due to release of pro-oxidant species. Assessment of such modifications provides non-specific measures of oxidative stress in human tissues...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email [email protected] ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
Articles
Marisa Iborra, Inés Moret, Francisco Rausell, Guillermo Bastida, Mariam Aguas, Elena Cerrillo, Pilar Nos, Belén Beltrán
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 1102–1106.
Published: 20 July 2011
...Marisa Iborra; Inés Moret; Francisco Rausell; Guillermo Bastida; Mariam Aguas; Elena Cerrillo; Pilar Nos; Belén Beltrán There is increasing interest in oxidative stress being a potential aetiological factor and/or a triggering factor in Crohn's disease, rather than a concomitant occurrence during...
Articles
Gene expression study of the flavodi-iron proteins from the cyanobacterium Synechocystis sp. PCC6803
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 216–218.
Published: 19 January 2011
...) nitrosative stress oxidative stress Synechocystis sp. PCC6803 The FDPs (flavodi-iron proteins), previously named A-type flavoproteins, are a family of soluble and modular enzymes with a two-domain conserved core constituted by a metallo-β-lactamase-like domain, at the N-terminus, linked...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
...David G. Nicholls Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1147–1160.
Published: 19 November 2009
... the neuroprotective and neurodestructive effects of NMDA receptor activity, as well as the factors that determine whether an episode of NMDA receptor activity is harmful or beneficial. It is becoming apparent that oxidative stress plays a role in promoting neuronal death in response to both hyper- and hypo-activity...
Articles
Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 819–823.
Published: 22 July 2009
... in the lungs, and COPD is also associated with features of accelerated aging in other organs, such as the cardiovascular and musculoskeletal systems. Cigarette smoke and other oxidative stresses result in cellular senescence and accelerate lung aging. There is also evidence that anti-aging molecules...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1309–1312.
Published: 19 November 2008
...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1304–1308.
Published: 19 November 2008
...Robert C. Hider; Yongmin Ma; Francisco Molina-Holgado; Alessandra Gaeta; Sourav Roy Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated...
Articles
Jack T. Rogers, Ashley I. Bush, Hyan-Hee Cho, Deborah H. Smith, Andrew M. Thomson, Avi L. Friedlich, Debomoy K. Lahiri, Peter J. Leedman, Xudong Huang, Catherine M. Cahill
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1282–1287.
Published: 19 November 2008
... is cleaved in a non-amyloidogenic pathway within its Aβ domain to release the neuroprotective APP ectodomain, APP(s). To adapt and counteract metal-catalysed oxidative stress, as during reperfusion from stroke, iron and cytokines induce the translation of both APP and ferritin (an iron storage protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1322–1328.
Published: 19 November 2008
... dismutase (SOD1) oxidative stress protein aggregation transition metal With an incidence of 1–2 per 100000 individuals per year, ALS (amyotrophic lateral sclerosis) (OMIM #105400), also referred to as Lou Gehrig's disease, is one of the most common motor neurodegenerative disorders...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1293–1298.
Published: 19 November 2008
... correspondence should be addressed (email [email protected] ). 17 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyloid hydrogen peroxide metal neurodegeneration oxidative stress reactive oxygen species The formation of extracellular deposits...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1066–1070.
Published: 19 September 2008
... to monitor vitamin E status and its interactions, including the use of stable-isotope-labelled vitamin E and metabonomics, are highlighted. Specifically, stable-isotope studies have been used to monitor vitamin E absorption, hepatic processing and lipoprotein transport. As oxidative stress may influence...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
...Judy Hirst; Martin S. King; Kenneth R. Pryde ROS (reactive oxygen species) are considered to be a major cause of cellular oxidative stress, linked to neuromuscular diseases and aging. Complex I (NADH:ubiquinone oxidoreductase) is one of the main contributors to superoxide production by mitochondria...
Articles
Stephen Barnes, Erin M. Shonsey, Shannon M. Eliuk, David Stella, Kerri Barrett, Om P. Srivastava, Helen Kim, Matthew B. Renfrow
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1037–1044.
Published: 19 September 2008
... orthogonal time-of-flight)–MS/MS as described for 4HNE and cytochrome c by Isom et al. [ 31 ]. © The Authors Journal compilation © 2008 Biochemical Society 2008 high-resolution mass spectrometry 4-hydroxynonenal (4HNE) lipoprotein oxidative stress post-translational modification protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1060–1065.
Published: 19 September 2008
...Jaffar Nourooz-Zadeh A large body of evidence indicates that measurement of F 2 -isoprostanes, specific prostaglandin F 2 -like compounds derived from the non-enzymatic peroxidation of arachidonic acid, is a reliable biomarker of oxidant stress in the human body. Since the discovery of F 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 930–934.
Published: 19 September 2008
... are currently envisaged. Among them, lipids and oxidative stress are considered as toxic candidates for the β-cell. The cellular link between fatty acids and ROS (reactive oxygen species) is essentially the mitochondrion, a key organelle for the control of insulin secretion. Mitochondria are the main source...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1077–1082.
Published: 19 September 2008
... and proteins are known to have bioactive effects and roles in cell signalling and modulation of gene expression. There is a need to develop more and better biomarkers of specific types of oxidative stress, and this will necessitate further enhancement of MS approaches to allow the analysis of oxidized products...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1045–1050.
Published: 19 September 2008
... and produce life extension in the nematode Caenorhabditis elegans . This suggests that dicarbonyl glycation damage to the mitochondrial proteome may be a preceding event to mitochondrial dysfunction leading to oxidative stress. Future research will address the functional charges in mitochondrial proteins...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 343–347.
Published: 21 May 2008
..., 30623 Hannover, Germany. 13 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 diabetes free radical oxidative stress pancreatic β-cell death reactive nitrogen species reactive oxygen species The pancreatic β-cell is in an extraordinary situation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1232–1235.
Published: 25 October 2007
... compilation © 2007 Biochemical Society 2007 mitochondrial DNA (mtDNA) mitochondrial DNA mutation mitochondrial dysfunction neurodegenerative disease oxidative stress Parkinson's disease The vast majority of a cell's energy is produced by mitochondria in a process of OXPHOS (oxidative...
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