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Keywords: oxidative stress
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Articles
Biochem Soc Trans (2024) BST20230550.
Published: 17 April 2024
.... Approximately 2.4 billion years ago, ‘The Great Oxygenation event’ changed the earth's atmospheric landscape. The significant increase in atmospheric oxygen levels introduced new opportunities, such as aerobic organisms, but also new challenges in resisting oxidative stress. As life evolved, organisms developed...
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Biochem Soc Trans (2024) BST20231059.
Published: 07 March 2024
... and appears to play a key role in the ability of the filament network to respond to oxidative stress. Current structural models and experimental evidence indicate that this cysteine residue may occupy a strategic position in the filaments in such a way that perturbations at this site, due to chemical...
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Biochem Soc Trans (2024) 52 (1): 65–74.
Published: 22 February 2024
...Opeyemi Stella Ademowo; Olubukola Oyebode; Roshita Edward; Myra E. Conway; Helen R. Griffiths; Irundika H.K. Dias Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS...
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Biochem Soc Trans (2024) 52 (1): 111–122.
Published: 04 January 2024
...Kathleen E. Taylor; Lucas G. Miller; Lydia M. Contreras Cells encounter a variety of stresses throughout their lifetimes. Oxidative stress can occur via a myriad of factors, including exposure to chemical toxins or UV light. Importantly, these stressors induce chemical changes (e.g. chemical...
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Biochem Soc Trans (2023) 51 (3): 1377–1385.
Published: 30 May 2023
...Yeping Wu; Ye-Wheen Lim; Robert G. Parton Oxidative stress is a feature of many disease conditions. Oxidative stress can activate a number of cellular pathways leading to cell death, including a distinct iron-dependent pathway involving lipid peroxidation, termed ferroptosis, but cells have evolved...
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Biochem Soc Trans (2023) 51 (3): 1169–1177.
Published: 04 May 2023
...Kathrin Ulrich Proteostasis and redox homeostasis are tightly interconnected and most protein quality control pathways are under direct redox regulation which allow cells to immediately respond to oxidative stress conditions. The activation of ATP-independent chaperones serves as a first line...
Articles
Biochem Soc Trans (2022) 50 (6): 1737–1751.
Published: 16 November 2022
... of the late sodium current (INaL), which impairs the action potential waveform and can cause severe cardiac arrhythmias. Moreover, long-term, low-dose exposure to PY displays oxidative stress in the heart, which could induce tissue remodeling and impairment. Isolated and preliminary evidence supports...
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Biochem Soc Trans (2021) 49 (5): 2189–2198.
Published: 19 October 2021
... reprogramming oxidative stress In 1836, Samuel Baup discovered an unknown product following the thermal decomposition of citric acid [ 1 ]. Four years later, Gustav Crasso synthesised the same compound by decarboxylation of cis -aconitate naming it itaconate — an anagram of aconitate [ 2 ]. Remarked...
Articles
Biochem Soc Trans (2017) 45 (6): 1295–1303.
Published: 17 November 2017
... and oxidative stress are implicated in many disorders. That these pathological processes can influence each other both up- and downstream makes for a complicated picture, but means that successfully targeting one area may have an effect on others. This targeting requires an understanding of the mechanisms...
Articles
Biochem Soc Trans (2015) 43 (5): 943–951.
Published: 09 October 2015
... of the mitochondria, whereas ABCB10 is involved in haem biosynthesis. They also play a role in preventing oxidative stress. Mutations in ABCB6 and ABCB7 have been linked to human disease. Recent crystal structures of yeast Atm1 and human ABCB10 have been key to identifying substrate-binding sites and transport...
Articles
Biochem Soc Trans (2015) 43 (4): 663–668.
Published: 03 August 2015
... be addressed (email mpsoares@igc.gulbenkian.pt ) . 19 2 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution License 3.0 . disease tolerance infection Nrf2 oxidative stress tissue damage...
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Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
Biochem Soc Trans (2015) 43 (4): 645–649.
Published: 03 August 2015
... Authors; published by Portland Press Limited 2015 cancer genome Kelch-like ECH-associated protein 1 (Keap1) nuclear factor E2-related factor 2 (Nrf2) oxidative stress The Cancer Genome Atlas (TCGA) Oxidative stress, an imbalance between the production and disposal of reactive oxygen...
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Biochem Soc Trans (2015) 43 (4): 669–673.
Published: 03 August 2015
... chemoprotection oxidative stress oscillation Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the cellular expression of a battery of protective genes countering oxidative stress, toxic substances, lipid peroxidation, inflammation, metabolic dysfunction and aging [ 1 – 3 ]. It senses...
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Biochem Soc Trans (2015) 43 (4): 632–638.
Published: 03 August 2015
... (reduction-oxidation) homoeostasis using a previously unrecognized NADPH-independent source of reducing power fuelled by dietary methionine. The NADPH-dependent systems are robustly redundant in liver, such that disruption of either TrxR1 or GR alone does not cause oxidative stress. However, disruption...
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Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
... © The Authors Journal compilation © 2014 Biochemical Society 2014 antioxidant glutathione oxidative stress peroxiredoxin protein oxidation reactive oxygen species Traditional endurance exercise is usually defined as activity that is sustained for between 30 min and 4 h [ 1...
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Biochem Soc Trans (2014) 42 (4): 1001–1005.
Published: 11 August 2014
..., during oxidative stress, plasma oxycholesterols could have damaging effects on BBB (blood–brain barrier) function and consequently on neuronal cells. Cholesterol-lowering drugs such as statins may prevent the modifications to LDL in mid-life and might show beneficial effects in later life. 1...
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Biochem Soc Trans (2014) 42 (4): 1006–1011.
Published: 11 August 2014
... thrombosis and impair fibrinolysis, accelerate the development of atherosclerosis, increase the extent of myocardial ischaemia, and increase susceptibility to myocardial infarction. The pathways underlying these effects are complex and poorly understood; however, particulate-induced oxidative stress...
Articles
Biochem Soc Trans (2014) 42 (4): 959–964.
Published: 11 August 2014
... the associated cellular redox imbalance. 1 To whom correspondence should be addressed (email mmuelle7@gwdg.de ). 26 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 antioxidant autism spectrum disorder mitochondrial disease oxidative stress reactive...
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Biochem Soc Trans (2014) 42 (4): 917–921.
Published: 11 August 2014
... To whom correspondence should be addressed (email ujakob@umich.edu ). 25 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 aging chaperone host defence oxidative stress protein unfolding Living an aerobic lifestyle is treacherous. ROS (reactive oxygen...
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Biochem Soc Trans (2014) 42 (2): 433–438.
Published: 20 March 2014
... Society 2014 advanced glycation end-product (AGE) female fertility oocyte aging ovarian aging oxidative stress polycystic ovarian syndrome (PCOS) Although reproductive success is related to positive outcome of intrauterine fetal growth, it begins in the ovary with the production...
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Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... oxidative stress synaptic plasticity The majority of AD (Alzheimer's disease) and PD (Parkinson's disease) cases are ‘sporadic’, which means that there is no clear genetic pathway that causes the onset of the disease. This makes it more difficult to identify which factors trigger...
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Biochem Soc Trans (2014) 42 (2): 511–517.
Published: 20 March 2014
... glycation, oxidation and nitration and DNA glycation and oxidation represent imperfections of physiological systems, and these processes increase in hyperglycaemia and metabolic stress conditions, e.g. dicarbonyl stress, oxidative stress and nitrosative stress. These abnormal metabolic states are widely...
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Biochem Soc Trans (2014) 42 (1): 42–46.
Published: 23 January 2014
...Rachel E. Martin; Zhenbo Cao; Neil J. Bulleid Hydrogen peroxide (H 2 O 2 ) can act as a signalling molecule affecting the cell cycle as well as contributing towards the oxidative stress response. The primary target of this molecule is oxidation-sensitive cysteine residues in proteins...
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Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
...Karen F.S. Bell Neurons are more vulnerable to oxidative stress than astrocytes, the reasons for which have yet to be fully elucidated. Understanding the cellular and molecular mechanisms which contribute to this enhanced vulnerability is key to efforts aimed at ameliorating neuronal health...
Articles
Biochem Soc Trans (2011) 39 (6): 1795–1798.
Published: 21 November 2011
... Journal compilation © 2011 Biochemical Society 2011 cellular stress DNA damage heat shock nuclear envelope oxidative stress The NE (nuclear envelope) is a structure composed of the outer and inner nuclear membranes, an inter-membrane space bridged by protein complexes, and an underlying...
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Biochem Soc Trans (2011) 39 (5): 1247–1253.
Published: 21 September 2011
... Biochemical Society 2011 cysteine oxidative stress redox signalling S-thiolation thiolstat Among the various intracellular signalling networks operational within the living cell, the ones based on phosphorylation and dephosphorylation may be the best known and understood. Nonetheless, other...
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Biochem Soc Trans (2011) 39 (5): 1279–1287.
Published: 21 September 2011
... protected against oxidation than intracellular sites in terms of the presence of both antioxidants (low molecular mass and enzymatic) and repair enzymes. The extracellular compartment may therefore be subject to greater oxidative stress, marked alterations in redox balance and an accumulation of damage due...
Articles
Biochem Soc Trans (2011) 39 (5): 1299–1304.
Published: 21 September 2011
...James E. Turner; Jos A. Bosch; Sarah Aldred Vigorous exercise is associated with oxidative stress, a state that involves modifications to bodily molecules due to release of pro-oxidant species. Assessment of such modifications provides non-specific measures of oxidative stress in human tissues...
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Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
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Biochem Soc Trans (2011) 39 (4): 1102–1106.
Published: 20 July 2011
...Marisa Iborra; Inés Moret; Francisco Rausell; Guillermo Bastida; Mariam Aguas; Elena Cerrillo; Pilar Nos; Belén Beltrán There is increasing interest in oxidative stress being a potential aetiological factor and/or a triggering factor in Crohn's disease, rather than a concomitant occurrence during...
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Biochem Soc Trans (2011) 39 (1): 216–218.
Published: 19 January 2011
...) nitrosative stress oxidative stress Synechocystis sp. PCC6803 The FDPs (flavodi-iron proteins), previously named A-type flavoproteins, are a family of soluble and modular enzymes with a two-domain conserved core constituted by a metallo-β-lactamase-like domain, at the N-terminus, linked...
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Biochem Soc Trans (2009) 37 (6): 1147–1160.
Published: 19 November 2009
... the neuroprotective and neurodestructive effects of NMDA receptor activity, as well as the factors that determine whether an episode of NMDA receptor activity is harmful or beneficial. It is becoming apparent that oxidative stress plays a role in promoting neuronal death in response to both hyper- and hypo-activity...
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Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
...David G. Nicholls Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress...
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Biochem Soc Trans (2009) 37 (4): 819–823.
Published: 22 July 2009
... in the lungs, and COPD is also associated with features of accelerated aging in other organs, such as the cardiovascular and musculoskeletal systems. Cigarette smoke and other oxidative stresses result in cellular senescence and accelerate lung aging. There is also evidence that anti-aging molecules...
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Biochem Soc Trans (2008) 36 (6): 1293–1298.
Published: 19 November 2008
... correspondence should be addressed (email d.allsop@lancaster.ac.uk ). 17 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyloid hydrogen peroxide metal neurodegeneration oxidative stress reactive oxygen species The formation of extracellular deposits...
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Biochem Soc Trans (2008) 36 (6): 1309–1312.
Published: 19 November 2008
...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...
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Biochem Soc Trans (2008) 36 (6): 1304–1308.
Published: 19 November 2008
...Robert C. Hider; Yongmin Ma; Francisco Molina-Holgado; Alessandra Gaeta; Sourav Roy Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated...
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Biochem Soc Trans (2008) 36 (6): 1322–1328.
Published: 19 November 2008
... dismutase (SOD1) oxidative stress protein aggregation transition metal With an incidence of 1–2 per 100000 individuals per year, ALS (amyotrophic lateral sclerosis) (OMIM #105400), also referred to as Lou Gehrig's disease, is one of the most common motor neurodegenerative disorders...
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Biochem Soc Trans (2008) 36 (5): 1066–1070.
Published: 19 September 2008
... to monitor vitamin E status and its interactions, including the use of stable-isotope-labelled vitamin E and metabonomics, are highlighted. Specifically, stable-isotope studies have been used to monitor vitamin E absorption, hepatic processing and lipoprotein transport. As oxidative stress may influence...
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Biochem Soc Trans (2008) 36 (5): 1060–1065.
Published: 19 September 2008
...Jaffar Nourooz-Zadeh A large body of evidence indicates that measurement of F 2 -isoprostanes, specific prostaglandin F 2 -like compounds derived from the non-enzymatic peroxidation of arachidonic acid, is a reliable biomarker of oxidant stress in the human body. Since the discovery of F 2...
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Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
...Judy Hirst; Martin S. King; Kenneth R. Pryde ROS (reactive oxygen species) are considered to be a major cause of cellular oxidative stress, linked to neuromuscular diseases and aging. Complex I (NADH:ubiquinone oxidoreductase) is one of the main contributors to superoxide production by mitochondria...
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Biochem Soc Trans (2008) 36 (5): 1037–1044.
Published: 19 September 2008
... Society 2008 high-resolution mass spectrometry 4-hydroxynonenal (4HNE) lipoprotein oxidative stress post-translational modification protein oxidation PTMs (post-translational modifications) of proteins occur extensively throughout their lifetime in a cell. For certain proteins, rather...
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Biochem Soc Trans (2008) 36 (5): 1077–1082.
Published: 19 September 2008
... compilation © 2008 Biochemical Society 2008 biomarker chlorohydrin chlorotyrosine free radical oxidative stress precursor-ion scanning HOCl is an oxidizing and chlorinating compound that can be generated by activated phagocytes as an antimicrobial agent. The enzyme responsible is MPO...
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Biochem Soc Trans (2008) 36 (3): 343–347.
Published: 21 May 2008
..., 30623 Hannover, Germany. 13 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 diabetes free radical oxidative stress pancreatic β-cell death reactive nitrogen species reactive oxygen species The pancreatic β-cell is in an extraordinary situation...
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Biochem Soc Trans (2007) 35 (5): 1147–1150.
Published: 25 October 2007
...B. Halliwell The terms ‘antioxidant’, ‘oxidative stress’ and ‘oxidative damage’ are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using...