...Elias S. Weiler; Tamas G. Szabo; Irmina Garcia-Carpio; Andreas Villunger The death fold domain-containing protein PIDD1 has recently attracted renewed attention as a regulator of the orphan cell death-related protease, Caspase-2. Caspase-2 can activate p53 to promote cell cycle arrest in response...

...Zhilin Yang; Ryan L. Hanson; Eric Batchelor The dynamics of p53 expression provide a mechanism to increase differentiation between cellular stresses and specificity in appropriate responses. Here, we review recent advances in our understanding of the molecular mechanisms regulating p53 dynamics...

... been proposed through which they can be formed, including entosis, cannibalism and emperipolesis among others. Recently, our laboratory discovered a role for mutant p53 in facilitating the formation of CIC and promoting genomic instability. These data and research by many others have uncovered...

... to metabolic re-programming of the liver. Reduced or abnormal ribosome production in response to cellular stress or mutations in genes encoding factors critical for ribosome biogenesis causes the activation of the tumour suppressor p53, which leads to re-programming of cellular transcription. The ribosomal...

... 2014 Biochemical Society 2014 acute kidney injury cell cycle microRNA (miRNA) p53 miRNAs are a large family of endogenous, small non-coding RNAs that have emerged as essential post-transcriptional regulators of gene expression. miRNAs are implicated in diverse cellular processes...

... knowledge about integration of NF-κB activity with cell cycle regulation, including newly characterized direct and indirect target genes in addition to the mechanisms through which NF-κB itself can be regulated by the cell cycle. cancer cell cycle cyclin D1 mitosis nuclear factor κB (NF-κB) p53...

... and illustrates its use in assessing the relative disorder of the wild-type p53 DNA-core-binding domain of cellular tumour antigen p53. The IM data were acquired on a Waters Synapt HDMS instrument following nESI (nanoelectrospray ionization) from ‘native’ and low-pH solution conditions. 1 Present...

... in extracellular matrix deposition and cell differentiation. 1 To whom correspondence should be addressed (email [email protected] ). 19 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 hepatocyte nuclear factor (HNF) microRNA (miRNA) p53 renal fibrosis...

.... allostery dynamics oligomerization p53 protein complex quaternary structure Although Nature does not function as an engineer [ 5 ], many of its systems share an important principle with engineered networks: modularity [ 6 ]. Modularity of natural systems can be studied from different...

... focuses mainly on HMGB1 and its interaction with chromatin and H1, as well as its chaperone role in the binding of certain transcription factors (e.g. p53) to their cognate DNA. 1 To whom correspondence should be addressed (email [email protected] ). 17 1 2012 © The Authors Journal...

... of the drug [ 6 ]. The tumour suppressor protein p53 is at the crossroads of cellular stress response pathways. By modulating cell-cycle arrest, DNA repair, cellular senescence, differentiation and apoptosis, p53 facilitates the repair and survival of damaged cells or eliminates severely damaged cells...

...Simon S. McDade; Dennis J. McCance The p53 family of transcription factors is made up of p53, p63 and p73, which share significant structural homology. In particular, transcriptional complexity and the expression of multiple protein isoforms are an emergent trait of all family members. p63...

...Monsef Benkirane; Claude Sardet; Olivier Coux The critical tumour suppressor p53 plays a major role in response to DNA damage and, more generally, to genotoxic stress. The regulation of its expression and functions is under very tight controls, and involves, in particular, an extremely complex set...

...Karen H. Vousden The p53 protein is an important tumour suppressor that is inactivated in many human cancers. Understanding how p53 is regulated and the downstream consequences of p53 function is helping us to devise novel therapies based on the reactivation of p53. Such approaches may be useful...

... a stabilized tetramer of the oligomerization domain of the human p53 tumour-suppressor protein by tandem dimerization. 1 email [email protected] . 22 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 covalent linkage oligomeric stability...

...H. Endo; A. Saito; P.H. Chan p53, a tumour suppressor, is involved in DNA repair and cell death processes and mediates apoptosis in response to death stimuli by transcriptional activation of pro-apoptotic genes and by transcription-independent mechanisms. In the latter process, p53 induces...

.... IRES activation under such pathophysiological conditions may involve ITAFs (IRES trans -acting factors), such as p53 or hnRNP AI (heterogeneous nuclear ribonucleoprotein AI), recently identified as inhibitory or activatory ITAFs respectively for FGF-2 IRES. FGF-2, also known as basic FGF, belongs...

... in tumours could lead to improved cancer diagnosis, choice of therapy and, ultimately, development of new drugs. 1 email [email protected] 12 6 2004 © 2004 The Biochemical Society 2004 ADP-ribosylation factor (ARF) chemotherapy DNA damage p53 RelA UV light...

...M.N. Holowaty; L. Frappier USP7 (also called HAUSP) is a de-ubiquitinating enzyme recently identified as a key regulator of the p53–mdm2 pathway, which stabilizes both p53 and mdm2. We have discovered that the Epstein–Barr nuclear antigen 1 protein of Epstein–Barr virus binds with high affinity...

...S. Laín Inactivation of the p53 function is a common event in cancer. Approx. 50% of human tumours express mutant p53 and there is evidence that in others, including many childhood tumours, p53 function is impaired in other ways. These defects on p53 function may be due to the alteration...

... She, which culminates in the transcriptional activation of the transcription factor Myc. Furthermore, we have also shown that this requirement for Src is abrogated in cells lacking the tumour suppressor p53, suggesting that another of Src's functions in normal cells is to suppress the actions of p53...

... checkpoint pathways. The p53 tumour suppressor can simulate growth arrest and apoptosis in response to DNA damage. Thus, p53 alone is not sufficient to specify these two mutually exclusive fates in damaged cells. The retinoblastoma tumour suppressor protein (RB) is a necessary downstream effector in p53...

...K. J. Campbell; N. R. Chapman; N. D. Perkins The cellular response to DNA-damaging agents is partly mediated by DNA-binding transcription factors such as p53 and nuclear factor κB (NF-κB). Typically NF-κB activation is associated with resistance to apoptosis. Following stimulation with UV light...

...M. P. Boland Nuclear factor κB (NF-κB), p53 and signal transducer and activator of transcription (STAT) proteins are transcription factors that are known to regulate cell fate in response to apoptotic stimuli. They may, therefore, represent components of drug responses that determine drug efficacy...

...E. K. Parkinson; J. Munro; K. Steeghs; V. Morrison; H. Ireland; N. Forsyth; S. Fitzsimmons; S. Bryce There is evidence that one critically short telomere may be recognized as DNA damage and, as a consequence, induce a p53/p21 WAF - and pl6 INK4A -dependent G1 cell cycle checkpoint to cause...