... necessarily involves a switch from expression of one set of genes to another, where each gene set represents a distinct cellular identity. liver pancreas reprogramming transcription factor transdifferentiation Yamanaka and Takahashi's seminal 2006 work inducing pluripotency in differentiated...

... 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 liver metaplasia pancreas reprogramming transdifferentiation Figure 1 Proposed mechanism for dexamethasone-dependent transdifferentiation of pancreatic B13 cells into hepatocyte-like cells Dexamethasone (Dex...

... [email protected] ). 9 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 β-cell diabetes insulin pancreas It has become increasingly clear in the last few years that pancreatic β-cell failure or destruction lies at the heart not only of Type 1...

...Bertrand Duvillié; Volodymyr Stetsyuk; Gaëlle Filhoulaud; Ghislaine Guillemain; Raphaël Scharfmann Understanding pancreatic development is important for at least three reasons: first, from a cognitive point of view, to understand the development of a complex organ, the pancreas; next, because...

... multiple low-dose injections produce gradual hyperglycaemia associated with insulitis [ 14 ]. It is interesting to note the regenerative capacity of the rat neonatal pancreas when challenged with a single dose of STZ: this triggers a transient hyperglycaemia within 48 h, which is normalized within 2 weeks...

... activity improves HGB by restoring hepatic GE. In the liver, but not in the pancreas, GK activity is regulated by a 68 kDa GKRP (GK regulatory protein), which inhibits GK competitively with respect to glucose [ 4 ]. The binding affinity of GKRP for GK is increased by fructose 6-phosphate and decreased...