..., are degraded, and therefore rendered inactive, by the enzyme pantetheinase (vanin), which is present in serum. In the present mini-review, we discuss the two strategies that have been put forward to overcome pantetheinase-mediated degradation of pantothenamides. The strategies effectively provide...

...Philippe Naquet; Giuseppina Pitari; Sylvestro Duprè; Franck Galland Pantetheinase is an ubiquitous enzyme which hydrolyses D -pantetheine into cysteamine and pantothenate (vitamin B 5 ) on the dissimilative pathway of CoA. Pantetheinase isoforms are encoded by the Vnn (vanin) genes and Vnn1...