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Keywords: pathogenesis
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Articles
Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1259–1268.
Published: 17 June 2022
... infection mycology pathogenesis Fungal pathogens (i.e. fungal organisms able to cause disease in a given host) are of high relevance for human health, affecting annually a billion people and causing 1.5 million deaths worldwide [ 1 ]. In addition, they are a threat to food crops [ 2 ] and other...
Articles
Varicella-zoster virus: molecular controls of cell fusion-dependent pathogenesis
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2415–2435.
Published: 01 December 2020
... by the cellular phosphatase, calcineurin. This review provides the current state-of-the-art knowledge about the molecular controls of cell fusion-dependent pathogenesis caused by VZV. Correspondence: Stefan L. Oliver ( [email protected] ) 27 9 2020 30 10 2020 3 11 2020 © 2020...
Articles
Burkholderia pseudomallei pathogenesis and survival in different niches
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 569–579.
Published: 13 March 2020
... to elucidate pathogenesis mechanisms of Bp , little is known about how a harmless soil bacterium adapts to different environmental conditions, in particular, the shift to a human host to become a highly virulent pathogen. The bacterium has a large genome encoding an armory of factors that assist the pathogen...
Articles
Apoptosis-like programmed cell death in the grey mould fungus Botrytis cinerea : genes and their role in pathogenicity
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1493–1498.
Published: 21 September 2011
... regulator of PCD in B. cinerea and that proper regulation of the host-induced PCD is essential for pathogenesis in this and other similar fungal pathogens. Bir1p belongs to the type-II (IAP-like) BIR-containing proteins, which also includes the mammalian survivin/BIRC5. As mentioned, IAPs are anti...
Articles
Molecular mechanisms of pathogenesis in a glycosphingolipid and a glycoprotein storage disease
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1453–1457.
Published: 24 November 2010
... metabolites in various cell types has shed light on mechanisms of disease pathogenesis and may pave the way for future development of new therapies for these LSDs. 1 To whom correspondence should be addressed (email [email protected] ). 10 5 2010 © The Authors Journal...
Articles
Systems biology of the metabolism of Mycobacterium tuberculosis
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1286–1289.
Published: 24 September 2010
.... Important discoveries linking the metabolism of M. tuberculosis and pathogenesis has renewed interest in this area of research. Previous experimental studies were limited to the analysis of individual genes or enzymes, whereas recent advances in computational systems biology and high-throughput experimental...
Articles
Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 819–823.
Published: 22 July 2009
... established and are key to our understanding of the pathogenic mechanisms in COPD and may be important for the development of new therapies. There is a relationship between chronic inflammatory diseases and aging, and the processes involved in aging may provide a novel mechanism in the pathogenesis of COPD...
Articles
ESCRTs and human disease
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 167–172.
Published: 20 January 2009
... been shown to cause ALS (amyotrophic lateral sclerosis) [ 30 ]. cancer endosomal sorting complex required for transport (ESCRT) endosome multivesicular body (MVB) neurodegeneration pathogenesis The endocytic down-regulation of numerous signalling receptors such as the EGFR (epidermal...
Articles
Aβ-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1101–1105.
Published: 26 October 2005
... of these enzymes and their potential as therapeutic targets. Aβ catabolism Alzheimer's disease endothelin-converting enzyme neprilysin pathogenesis therapeutic intervention 1 To whom correspondence should be addressed (email [email protected] ). 28 7 2005 © 2005 The Biochemical...
Articles
Yersinia pestis and plague
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (1): 104–107.
Published: 01 February 2003
... July 2002 Copyright 2003 Biochemical Society 2003 pathogenesis pathogen evolution type III system Abbreviations used: Hms, haemin storage. 104 Biochemical Society Transactions (2003) Volume 31, part 1 Yersinia pestis and plague R.W. Titball*1, J. Hill*, D.G. Lawton and K.A...