... different. Although intense research over the past decades has advanced our understanding of autophagy, fundamental questions remain to be addressed. This review will focus on molecular principles and open questions regarding the formation of omegasomes and phagophores in nonselective mammalian autophagy...

... formation, with a particular focus on budding yeast and mammalian cells. Upon autophagy induction, the nucleation of the phagophore takes place at distinct subcellular places. In yeast, normally there is only one of these locations per cell and it is called the PAS [ 17–19 ] and it is found...