[email protected] ) 20 12 2019 3 3 2020 9 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 drug effects pharmacology repurposing Originally published over 70 years ago, the use of anti-folates as a treatment...

...) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY-NC-ND) . ABCG2 ABC transporter ATPase multidrug pump pharmacology Multidrug resistance (MDR) can...

... pyrophosphates (PP-IPs)–a specialized, ‘energetic’ group of cell-signalling molecules in which multiple phosphate and diphosphate groups are crammed around a cyclohexane polyol scaffold. inositol phosphate cell-signalling drug pharmacology structure The inositol pyrophosphates (PP-IPs; Figure 1...

... 8 Gatliff J.L. Campanella M. TSPO is a REDOX regulator of Cell Mitophagy 2015 doi:10.1042/BST20150037 9 Midzak A. Zirkin A. Papadopoulos V. Translocator protein: pharmacology and steroidogenesis 2015 doi:10.1042/BST20150061 10 Middletone R.J. Liu G.J...

... of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are not specific for Panx1 and have additional effects on other proteins. Therefore, molecular tools, such as RNA interference and knockout animals...

...-arrestin crystal structure G-protein-coupled receptor (GPCR) modelling pharmacology What of the future? Arising from the meeting, we think that it is possible to see a number of important areas for future research in GPCR biology. The crystal structures are wonderfully revealing, but provide...

... may well be totally different, as they are more and more envisioned as opening new routes for pharmacological research. Pluripotent stem cells indeed possess the main attributes that make them theoretically fully equipped for the development of cell-based assays in the fields of drug discovery...