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Keywords: phosphatidylinositol
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Biochem Soc Trans (2020) 48 (1): 187–197.
Published: 17 February 2020
... ( dematteis@tigem.it ) 6 11 2019 20 1 2020 24 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 endoplasmic reticulum golgi apparatus membrane contact sites phosphatidylinositol Membrane contact sites (MCSs...
Biochem Soc Trans (2019) 47 (5): 1291–1305.
Published: 28 October 2019
... with effectors. ( A ) A typical phosphoinositide (PIPn) structure is represented by C38:4 PI3P (sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate). The fatty acids acylated in the sn-1 and sn-2 positions of the glycerol backbone (green) are labelled with both their common and systematic name...
Biochem Soc Trans (2019) 47 (4): 985–995.
Published: 05 July 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 cadherin caveolae phosphatidylinositol plasma membrane Physical connections between cells influence the morphogenesis, homeostasis and physiology of diverse tissues. These connections range from the cell–cell junctions...
Biochem Soc Trans (2016) 44 (1): 286–292.
Published: 09 February 2016
...Shamshad Cockcroft; Kathryn Garner; Shweta Yadav; Evelyn Gomez-Espinoza; Padinjat Raghu Phosphatidylinositol (PI) is the precursor lipid for the synthesis of PI 4,5-bisphosphate [PI(4,5) P 2 ] at the plasma membrane (PM) and is sequentially phosphorylated by the lipid kinases, PI 4-kinase...
Biochem Soc Trans (2014) 42 (5): 1383–1388.
Published: 18 September 2014
...Ashutosh Tripathi; Aaron H. Nile; Vytas A. Bankaitis The physiological functions of phosphatidylinositol (PtdIns)-transfer proteins (PITPs)/phosphatidylcholine (PtdCho)-transfer proteins are poorly characterized, even though these proteins are conserved throughout the eukaryotic kingdom. Much...
Biochem Soc Trans (2014) 42 (5): 1343–1348.
Published: 18 September 2014
... mimetic phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatidylinositol phosphoinositide 3-kinase (PI3K) Research into phosphoinositide-dependent signalling has been around for many decades and has now become a staple ingredient of many important mechanisms governing...
Biochem Soc Trans (2012) 40 (2): 451–456.
Published: 21 March 2012
...Shamshad Cockcroft; Kathryn Garner PITPs (phosphatidylinositol transfer proteins) are characterized by the presence of the PITP domain whose biochemical properties of binding and transferring PI (phosphatidylinositol) are well studied. Despite their wide-spread expression in both unicellular...
Biochem Soc Trans (2009) 37 (5): 1115–1120.
Published: 21 September 2009
...-stabilizing effects of VPA and LiCl in bipolar disorder. 1 To whom correspondence should be addressed (email M.Schweizer@hw.ac.uk ). 29 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 bipolar disorder lithium phosphatidylinositol phosphoribosyl...
Biochem Soc Trans (2007) 35 (2): 245–249.
Published: 20 March 2007
... mammalian target of rapamycin (mTOR) p110 phosphatidylinositol phosphoinositide 3-kinase (PI3K) PI3K (phosphoinositide 3-kinase) is activated by receptor tyrosine kinases and other cell-surface receptors to synthesize the lipid second messenger PIP 3 (phosphatidylinositol-3,4,5-trisphosphate...
Biochem Soc Trans (2006) 34 (3): 363–366.
Published: 22 May 2006
... lipid homoeostasis Nir2 phosphatidic acid phosphatidylinositol trans -Golgi network The endocytic and secretory organelles possess a unique lipid composition that effectively prevents their homogenization and maintains their distinct structural and functional identities [ 1 ]. The distinct...
Biochem Soc Trans (2005) 33 (5): 1150–1153.
Published: 26 October 2005
... and metabolism of S. cerevisiae . Depletion of zinc from the growth medium of wild-type cells results in alterations in phospholipid composition including an increase in PI (phosphatidylinositol) and a decrease in phosphatidylethanolamine. These changes can be attributed to an increase in PIS1 -encoded PI...
Biochem Soc Trans (2004) 32 (6): 1057–1059.
Published: 26 October 2004
...A.D. Postle; H. Dombrowsky; H. Clarke; C.J. Pynn; G. Koster; A.N. Hunt Mammalian cell PtdIns (phosphatidylinositol) in vivo is enriched in the sn -1-stearoyl 2-arachidonoyl species, the physiological precursor of phosphatidylinositol 4,5-bisphosphate. Mechanisms regulating this specificity...
Biochem Soc Trans (2004) 32 (6): 1063–1065.
Published: 26 October 2004
...A.N. Hunt; J.G. Alb; G. Koster; A.D. Postle; V.A. Bankaitis The mammalian phospholipid exchange protein PITPα (phosphatidylinositol transfer protein alpha), found in both extranuclear and endonuclear compartments, is thought in part to facilitate nuclear import of the PtdIns (phosphatidylinositol...
Biochem Soc Trans (2004) 32 (2): 326–329.
Published: 01 April 2004
... associated with PIP5Ks (phosphatidylinositol 4-phosphate 5-kinases), the enzymes that synthesize PtdIns(4,5) P 2 . Btk functions as a shuttle to bring PIP5K to the plasma membrane as a means of stimulating PtdIns(4,5) P 2 synthesis. The Btk–PIP5K complex appears to localize to lipid rafts. This complex...