...Daan Vorselen Phagocytosis triggered by the phospholipid phosphatidylserine (PS) is key for the removal of apoptotic cells in development, tissue homeostasis and infection. Modulation of PS-mediated phagocytosis is an attractive target for therapeutic intervention in the context of atherosclerosis...

[email protected] ). 26 11 2015 © 2016 Authors; published by Portland Press Limited 2016 ceramide cholesterol contact site endoplasmic reticulum phosphatidylserine phosphoinositide The membrane compartments of eukaryotic cells communicate via tubulovesicular carriers that bud from...

... cell interaction phosphatidylserine Extracellular vesicles were first reported many years ago [ 1 ]. In the subsequent decades, diverse extracellular vesicles released from different cells were described. Ectosomes, plasma membrane MVs (microvesicles), exosomes, microparticles, apotoptotic...

... the local densities of phosphatidylserine and PtdIns(4,5) P 2 on the inner leaflet of the plasma membrane are sufficient to drive Ca 2+ -activated membrane docking during a physiological Ca 2+ signal. 1 To whom correspondence should be addressed (email [email protected] ). 26 6 2007 ©...

... synthase activity and a decrease in the activities of several CDP-diacylglycerol pathway enzymes including the CHO1 -encoded PS (phosphatidylserine) synthase. The reduction in PS synthase in response to zinc depletion is due to a repression mechanism that involves the UAS INO (inositol upstream activating...

...D.R. Voelker Phosphatidylserine (PtdSer) is synthesized in the endoplasmic reticulum and its subdomains associated with the mitochondria [MAM (mitochondria-associated membrane)] and subsequently transported to the loci of the PtdSer decarboxylases, Pds1p (phosphatidylserine decarboxylase 1 encoded...

...M.C.M. Vissers; M.B. Hampton We have investigated the role of neutrophil oxidants in the surface changes that result in recognition and uptake of neutrophils by macrophages. We have shown that H 2 O 2 produced by stimulated neutrophils is essential for the surface expression of phosphatidylserine...