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Tribbles breaking bad: TRIB2 suppresses FOXO and acts as an oncogenic protein in melanoma

Wolfgang Link

Biochem Soc Trans (2015) 43 (5): 1085–1088.

https://doi.org/10.1042/BST20150102

Published: 09 October 2015

... phosphoinositide 3-kinase (PI3K) tribbles TRIB2 (tribbles homolog 2) This work was supported by the Bayer AG [grant number 2012-08-0765]; and the Fundação para a Ciência e a Tecnologia (FCT) Research Center [grant number UID/BIM/04773/2013 CBMR 1334]. Tribbles was identified 15 years ago in three...

View articletitled, Tribbles breaking bad: TRIB2 suppresses FOXO and acts as an oncogenic protein in melanoma

Articles

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

John D. Hayes, Sudhir Chowdhry, Albena T. Dinkova-Kostova, Calum Sutherland

Biochem Soc Trans (2015) 43 (4): 611–620.

https://doi.org/10.1042/BST20150011

Published: 03 August 2015

... degradation via the cullin-3 (Cul3)–RING ubiquitin ligase CRL Keap1 . In the latter case, we speculate that growth factors increase the stability of Nrf2 by stimulating phosphoinositide 3-kinase (PI3K)−protein kinase B (PKB)/Akt signalling, which in turn results in inhibitory phosphorylation of glycogen...

View articletitled, Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

Articles

New insight into the intracellular roles of class II phosphoinositide 3-kinases

Tania Maffucci, Marco Falasca

Biochem Soc Trans (2014) 42 (5): 1378–1382.

https://doi.org/10.1042/BST20140140

Published: 18 September 2014

...Tania Maffucci; Marco Falasca In the last few years, an increased attention to class II isoforms of phosphoinositide 3-kinase (PI3K) has emerged, mainly fuelled by evidence suggesting a distinct non-redundant role for these enzymes compared with other PI3Ks. Despite this renewed interest, many...

View articletitled, New insight into the intracellular roles of class II phosphoinositide 3-kinases

Articles

Chemical intervention tools to probe phosphoinositide-dependent signalling

Rudiger Woscholski

Biochem Soc Trans (2014) 42 (5): 1343–1348.

https://doi.org/10.1042/BST20140186

Published: 18 September 2014

... phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatidylinositol phosphoinositide 3-kinase (PI3K) Research into phosphoinositide-dependent signalling has been around for many decades and has now become a staple ingredient of many important mechanisms governing cellular function...

View articletitled, Chemical intervention tools to probe phosphoinositide-dependent signalling

Articles

Signalling specificity in the Akt pathway in breast cancer

Abbe R. Clark, Alex Toker

Biochem Soc Trans (2014) 42 (5): 1349–1355.

https://doi.org/10.1042/BST20140160

Published: 18 September 2014

[email protected] ). 30 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Akt breast cancer cancer phosphoinositide 3-kinase (PI3K) phosphorylation signalling substrate The serine/threonine protein kinase Akt, also known as protein kinase B (PKB), plays a key...

View articletitled, Signalling specificity in the Akt pathway in breast cancer

Articles

PI3K/Akt-mediated regulation of p53 in cancer

Aswin G. Abraham, Eric O’Neill

Biochem Soc Trans (2014) 42 (4): 798–803.

https://doi.org/10.1042/BST20140070

Published: 11 August 2014

... (ARF) murine double minute 2 (MDM2) phosphoinositide 3-kinase (PI3K) TP53 A.G.A. and E.O'N. are funded by Cancer Research UK, the Medical Research Council and a Clarendon Fund fellowship. References 1 Hanahan D. Weinberg R.A. Hallmarks of cancer: the next generation Cell...

View articletitled, PI3K/Akt-mediated regulation of p53 in cancer

Articles

Anticipating mechanisms of resistance to PI3K inhibition in breast cancer: a challenge in the era of precision medicine

Cedric Leroy, Romain J. Amante, Mohamed Bentires-Alj

Biochem Soc Trans (2014) 42 (4): 733–741.

https://doi.org/10.1042/BST20140034

Published: 11 August 2014

... phosphoinositide 3-kinase (PI3K) signalling targeted therapy Pan-PI3K selective inhibitors target all class IA PI3Ks. Specific inhibition of PI3K mostly decreases mTORC1 activity, which, in principle, may evoke fewer side effects than inhibition of both mTORC1 and mTORC2. This class of inhibitors should...

View articletitled, Anticipating mechanisms of resistance to PI3K inhibition in breast cancer: a challenge in the era of precision medicine

Articles

Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme

Jack U. Flanagan, Peter R. Shepherd

Biochem Soc Trans (2014) 42 (1): 120–124.

https://doi.org/10.1042/BST20130255

Published: 23 January 2014

... phosphoinositide 3-kinase (PI3K) The class I PI3Ks (phosphoinositide 3-kinases) are a family of closely related enzymes that are among the first level of cell signalling molecules regulated by tyrosine kinases, by small G-proteins Rac and Ras and by the βγ subunits of heterotrimeric G-proteins [ 1...

View articletitled, Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme

Articles

Protein kinase networks that limit TLR signalling

Kristopher Clark

Biochem Soc Trans (2014) 42 (1): 11–24.

https://doi.org/10.1042/BST20130124

Published: 23 January 2014

... within the greater context of the field. 1 email [email protected] 26 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 inhibitor of nuclear factor κB kinase (IKK) innate immunity mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase...

View articletitled, Protein kinase networks that limit TLR signalling

Articles

Targeting phosphoinositide 3-kinase δ for allergic asthma

Wendy C. Rowan, Janet L. Smith, Karen Affleck, Augustin Amour

Biochem Soc Trans (2012) 40 (1): 240–245.

https://doi.org/10.1042/BST20110665

Published: 19 January 2012

... correspondence should be addressed (email [email protected] ). 26 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 allergic asthma B-cell cytokine mast cell phosphoinositide 3-kinase (PI3K) T-cell Asthma is a common respiratory disease. It has been...

View articletitled, Targeting phosphoinositide 3-kinase δ for allergic asthma

Articles

Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

Edita Aksamitiene, Anatoly Kiyatkin, Boris N. Kholodenko

Biochem Soc Trans (2012) 40 (1): 139–146.

https://doi.org/10.1042/BST20110609

Published: 19 January 2012

... 5 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Akt cross-talk mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K) Ras A cell in an organism is immersed in an ocean of growth factors and hormones, yet how signalling networks...

View articletitled, Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

Articles

Blocking the mTOR pathway: a drug discovery perspective

Carlos Garcia-Echeverria

Biochem Soc Trans (2011) 39 (2): 451–455.

https://doi.org/10.1042/BST0390451

Published: 22 March 2011

... in cancer patients. 1 email [email protected] 25 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cancer mammalian target of rapamycin inhibitor (mTOR inhibitor) phosphoinositide 3-kinase (PI3K) rapalogue targeted therapy Compounds...

View articletitled, Blocking the mTOR pathway: a drug discovery perspective

Articles

Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling

Melanie J. Welham, Emmajayne Kingham, Yolanda Sanchez-Ripoll, Benjamin Kumpfmueller, Michael Storm, Heather Bone

Biochem Soc Trans (2011) 39 (2): 674–678.

https://doi.org/10.1042/BST0390674

Published: 22 March 2011

... Journal compilation © 2011 Biochemical Society 2011 cell cycle embryonic stem cell glycogen synthase kinase 3 (GSK-3) phosphoinositide 3-kinase (PI3K) pluripotency proliferation self-renewal ESCs are derived from early pre-implantation embryos and, when cultured appropriately, can...

View articletitled, Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling

Articles

Form and flexibility in phosphoinositide 3-kinases

Roger Williams, Alex Berndt, Simon Miller, Wai-Ching Hon, Xuxiao Zhang

Biochem Soc Trans (2009) 37 (4): 615–626.

https://doi.org/10.1042/BST0370615

Published: 22 July 2009

... of the catalytic cycle of the enzymes. 1 To whom correspondence should be addressed (email [email protected] ). 25 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer p85 p110 phosphoinositide 3-kinase (PI3K) phosphoinositide 3,4,5-trisphosphate...

View articletitled, Form and flexibility in phosphoinositide 3-kinases

Articles

Down-regulation of epidermal growth factor receptor signalling within multivesicular bodies

Emily R. Eden, Ian J. White, Clare E. Futter

Biochem Soc Trans (2009) 37 (1): 173–177.

https://doi.org/10.1042/BST0370173

Published: 20 January 2009

... epidermal growth factor receptor (EGFR) endosomal sorting complex required for transport (ESCRT) multivesicular body (MVB) phosphoinositide 3-kinase (PI3K) protein tyrosine phosphatase 1B (PTP1B) EGF (epidermal growth factor) binding to the EGFR (EGF receptor) promotes increased RTK (receptor...

View articletitled, Down-regulation of epidermal growth factor receptor signalling within multivesicular bodies

Articles

PI3K inhibitors for cancer treatment: where do we stand?

Sauveur-Michel Maira, Frédéric Stauffer, Christian Schnell, Carlos García-Echeverría

Biochem Soc Trans (2009) 37 (1): 265–272.

https://doi.org/10.1042/BST0370265

Published: 20 January 2009

... for the treatment of hematological malignancies. Targeting the PI3-Kinase Pathway in Cancer (AACR Special Conference) 2008 MA, U.S.A. Cambridge 11 14 November 2008 cancer mammalian target of rapamycin (mTOR) phosphoinositide 3-kinase (PI3K) small-molecule kinase inhibitor VEGF...

View articletitled, PI3K inhibitors for cancer treatment: where do we stand?

Articles

A complex interplay between Akt, TSC2 and the two mTOR complexes

Jingxiang Huang, Brendan D. Manning

Biochem Soc Trans (2009) 37 (1): 217–222.

https://doi.org/10.1042/BST0370217

Published: 20 January 2009

... (mTORC) phosphoinositide-dependent kinase 1 (PDK1) phosphoinositide 3-kinase (PI3K) Rheb tuberous sclerosis complex (TSC) Dysregulation of the serine/threonine protein kinase Akt [or PKB (protein kinase B)] underlies the pathology of a number of common human diseases, such as cancer...

View articletitled, A complex interplay between Akt, TSC2 and the two mTOR complexes

Articles

Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase

J.S. Oak, M.P. Matheu, I. Parker, M.D. Cahalan, D.A. Fruman

Biochem Soc Trans (2007) 35 (5): 1109–1113.

https://doi.org/10.1042/BST0351109

Published: 25 October 2007

... ]. 1 To whom correspondence should be addressed (email [email protected] ). 10 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chemokine chemotaxis leukaemia lymphocyte phosphoinositide 3-kinase (PI3K) two-photon microscopy Lymphocytes (T- and B...

View articletitled, Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase

Articles

P2X 7 receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators

J. Hewinson, A.B. MacKenzie

Biochem Soc Trans (2007) 35 (5): 1168–1170.

https://doi.org/10.1042/BST0351168

Published: 25 October 2007

... phosphoinositide 3-kinase (PI3K) reactive nitrogen species reactive oxygen species It is well established that ATP acts as a key extracellular signalling molecule that is implicated in numerous cellular processes from synaptic transmission to inflammation [ 1 ]. Extracellular ATP activates a class...

View articletitled, P2X 7 receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators

Articles

The role of SHIP1 in T-lymphocyte life and death

G. Gloire, C. Erneux, J. Piette

Biochem Soc Trans (2007) 35 (2): 277–280.

https://doi.org/10.1042/BST0350277

Published: 20 March 2007

... ] T-cells H 2 O 2 Anti-apoptotic [ 38 ] 1 To whom correspondence should be addressed (email [email protected] ). 9 9 2006 © 2007 The Biochemical Society 2007 apoptosis cell proliferation nuclear factor κB (NF-κB) phosphoinositide 3-kinase (PI3K...

View articletitled, The role of SHIP1 in T-lymphocyte life and death

Articles

Inhibiting PTEN

E. Rosivatz

Biochem Soc Trans (2007) 35 (2): 257–259.

https://doi.org/10.1042/BST0350257

Published: 20 March 2007

... insulin signalling phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatidylinositol 3,4,5-trisphosphate phosphoinositide 3-kinase (PI3K) vanadate The key event in glucose signalling is the activation of GS (glycogen synthase) and increased glucose uptake, causing...

View articletitled, Inhibiting PTEN

Articles

Regulation of class III (Vps34) PI3Ks

Y. Yan, J.M. Backer

Biochem Soc Trans (2007) 35 (2): 239–241.

https://doi.org/10.1042/BST0350239

Published: 20 March 2007

... The Biochemical Society 2007 autophagy beclin-1 mammalian target of rapamycin (mTOR) phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34) yeast Vps34 was cloned from Saccharomyces cerevisiae by Herman and Emr [ 1 ], and was first described as a gene essential for the sorting...

View articletitled, Regulation of class III (Vps34) PI3Ks

Articles

The role of class I phosphoinositide 3-kinase in T-cell function and autoimmunity

D.A. Fruman

Biochem Soc Trans (2007) 35 (2): 177–180.

https://doi.org/10.1042/BST0350177

Published: 20 March 2007

... autoimmunity knockout mouse phosphoinositide 3-kinase (PI3K) regulatory T-cell (Treg) T-cell thymocyte Due to space constraints, I refer the reader to other reviews with a detailed description of PI3K isoform structure, regulation and activation mechanisms in T-cells [ 1 , 2 ]. To briefly...

View articletitled, The role of class I phosphoinositide 3-kinase in T-cell function and autoimmunity

Articles

Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models

T. Sasaki, J. Sasaki, K. Watanabe, A. Suzuki

Biochem Soc Trans (2007) 35 (2): 215–218.

https://doi.org/10.1042/BST0350215

Published: 20 March 2007

... and pathological situations. lipid product neutrophil phosphatidylinositol 3,4,5-trisphosphate phosphoinositide 3-kinase (PI3K) Src homology 2-containing inositol phosphatase-1 (SHIP1) transgenic mouse model The PI3Ks (phosphoinositide 3-kinases) constitute a family of evolutionarily conserved...

View articletitled, Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models

Articles

The PI3K p110δ controls T-cell development, differentiation and regulation

D.T. Patton, F. Garçon, K. Okkenhaug

Biochem Soc Trans (2007) 35 (2): 167–171.

https://doi.org/10.1042/BST0350167

Published: 20 March 2007

..., we review the role of PI3Ks in T-cell development and function. 1 To whom correspondence should be addressed (email [email protected] ). 17 11 2006 © 2007 The Biochemical Society 2007 colitis forkhead box O (Foxo) p110δ phosphoinositide 3-kinase (PI3K) T-cell...

View articletitled, The PI3K p110δ controls T-cell development, differentiation and regulation

Articles

T-lymphocyte navigation and migration: beyond the PI3K paradigm

L. Smith, A. Webb, S.G. Ward

Biochem Soc Trans (2007) 35 (2): 193–198.

https://doi.org/10.1042/BST0350193

Published: 20 March 2007

... paper. 1 To whom correspondence should be addressed (email [email protected] ). 20 11 2006 © 2007 The Biochemical Society 2007 cell migration chemokine GTPase phosphoinositide 3-kinase (PI3K) protein kinase C (PKC) T-lymphocyte Trafficking of T-lymphocytes...

View articletitled, T-lymphocyte navigation and migration: beyond the PI3K paradigm

Articles

Regulation of class IA PI3Ks

H. Wu, Y. Yan, J.M. Backer

Biochem Soc Trans (2007) 35 (2): 242–244.

https://doi.org/10.1042/BST0350242

Published: 20 March 2007

... to the nSH2 domain facilitates subsequent activation by Ras–p110 interactions [ 45 ]. adaptor-binding domain (ABD) Breakpoint Cluster Region (BCR) domain structure p85 phosphoinositide 3-kinase (PI3K) Src homology 2 domain (SH2 domain) PI3Ks are critical regulators of proliferation, motility...

View articletitled, Regulation of class IA PI3Ks

Articles

Regulation of B-lymphocyte activation by the PH domain adaptor protein Bam32/DAPP1

A.J. Marshall, T. Zhang, M. Al-Alwan

Biochem Soc Trans (2007) 35 (2): 181–182.

https://doi.org/10.1042/BST0350181

Published: 20 March 2007

... for phosphotyrosine and 3-phosphoinositides 1 (Bam32/DAPP1) B-lymphocyte phosphoinositide 3-kinase (PI3K) pleckstrin homology domain (PH domain) Bam32 (B-cell adaptor molecule of 32 kDa)/DAPP1 (dual adaptor for phosphotyrosine and 3-phosphoinositides 1) is a 32 kDa signalling protein possessing an N...

View articletitled, Regulation of B-lymphocyte activation by the PH domain adaptor protein Bam32/DAPP1

Articles

Isoform-selective PI3K inhibitors as novel therapeutics for the treatment of acute myocardial infarction

J. Doukas, W. Wrasidlo, G. Noronha, E. Dneprovskaia, J. Hood, R. Soll

Biochem Soc Trans (2007) 35 (2): 204–206.

https://doi.org/10.1042/BST0350204

Published: 20 March 2007

... at an interventional setting, rendering the patient inaccessible during times when an anti-ischaemia therapy would be most effective [ 4 ]. inflammation ischaemia myocardial infarction oedema phosphoinositide 3-kinase (PI3K) © 2007 The Biochemical Society 2007 30 10 2006 1 To whom...

View articletitled, Isoform-selective PI3K inhibitors as novel therapeutics for the treatment of acute myocardial infarction

Articles

Phosphoinositide 3-kinase-dependent regulation of phospholipase Cγ

T. Maffucci, M. Falasca

Biochem Soc Trans (2007) 35 (2): 229–230.

https://doi.org/10.1042/BST0350229

Published: 20 March 2007

... © 2007 The Biochemical Society 2007 growth factor phospholipase C (PLC) pleckstrin homology domain (PH domain) phosphoinositide 3-kinase (PI3K) Src homology 2 domain (SH2 domain) tyrosine phosphorylation PtdIns(4,5) P 2 is a minor phospholipid component of cell membrane (∼0.5...

View articletitled, Phosphoinositide 3-kinase-dependent regulation of phospholipase Cγ

Articles

PI3K signalling during influenza A virus infections

B.G. Hale, R.E. Randall

Biochem Soc Trans (2007) 35 (2): 186–187.

https://doi.org/10.1042/BST0350186

Published: 20 March 2007

... phosphoinositide 3-kinase (PI3K) p85 Both seasonal and pandemic outbreaks of influenza A virus pose a serious threat to global public health [ 1 ]. Three major human pandemics occurred in the 20th Century. The first, in 1918, known as ‘Spanish flu’, was the most severe and is estimated to have caused over...

View articletitled, PI3K signalling during influenza A virus infections

Articles

A cascade involving p85, Cdc42 and septin 2 regulates cytokinesis

V. Silió, M. Marqués, I. Cortés, S. Zuluaga, A.C. Carrera

Biochem Soc Trans (2007) 35 (2): 222–224.

https://doi.org/10.1042/BST0350222

Published: 20 March 2007

... phosphoinositide 3-kinase (PI3K) septin Cell division ends with cytokinesis, the separation of the mother cell cytosol between the two daughter cells. A large number of proteins, some of which have been identified in genetic screening of yeast, play a role in this process, which follows DNA separation...

View articletitled, A cascade involving p85, Cdc42 and septin 2 regulates cytokinesis

Articles

Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits?

B. Geering, P.R. Cutillas, B. Vanhaesebroeck

Biochem Soc Trans (2007) 35 (2): 199–203.

https://doi.org/10.1042/BST0350199

Published: 20 March 2007

..., based on possible effects of p85 deletion on phosphatases acting on PIP 3 , are discussed. 1 To whom correspondence should be addressed (email [email protected] ). 21 11 2006 © 2007 The Biochemical Society 2007 insulin p85 phosphoinositide 3-kinase (PI3K...

View articletitled, Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits?

Articles

Chemically targeting the PI3K family

Z.A. Knight, K.M. Shokat

Biochem Soc Trans (2007) 35 (2): 245–249.

https://doi.org/10.1042/BST0350245

Published: 20 March 2007

... mammalian target of rapamycin (mTOR) p110 phosphatidylinositol phosphoinositide 3-kinase (PI3K) PI3K (phosphoinositide 3-kinase) is activated by receptor tyrosine kinases and other cell-surface receptors to synthesize the lipid second messenger PIP 3 (phosphatidylinositol-3,4,5-trisphosphate...

View articletitled, Chemically targeting the PI3K family

Articles

Phosphoinositide 3-kinases and regulation of embryonic stem cell fate

M.J. Welham, M.P. Storm, E. Kingham, H.K. Bone

Biochem Soc Trans (2007) 35 (2): 225–228.

https://doi.org/10.1042/BST0350225

Published: 20 March 2007

... bone morphogenetic protein (BMP) embryonic stem cell (ES cell) phosphoinositide 3-kinase (PI3K) pluripotency self-renewal ES cell lines exhibit the unique property of pluripotency, i.e. the ability to differentiate into all cell lineages comprising the adult organism [ 1 , 2 ]. Pluripotency...

View articletitled, Phosphoinositide 3-kinases and regulation of embryonic stem cell fate

Articles

p110δ is required for innate immunity to transplantable lymphomas

A. Saudemont, K. Okkenhaug, F. Colucci

Biochem Soc Trans (2007) 35 (2): 183–185.

https://doi.org/10.1042/BST0350183

Published: 20 March 2007

... p110δ-targeted mice to address its role in NK cell responses to tumour cells. These mice, which we will refer to as p110δ-KI (knock-in), are on a C57BL/6 (B6) background and have been described previously [ 3 ]. cytotoxicity lymphoma natural killer cell (NK cell) p110δ phosphoinositide 3...

View articletitled, p110δ is required for innate immunity to transplantable lymphomas

Articles

Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?

M.A. Guthridge, A.F. Lopez

Biochem Soc Trans (2007) 35 (2): 250–252.

https://doi.org/10.1042/BST0350250

Published: 20 March 2007

... cytokines and growth factors are able to control these pleiotropic responses. 1 To whom correspondence should be addressed (email [email protected] ). 26 10 2006 © 2007 The Biochemical Society 2007 14-3-3 protein cytokine growth factor phosphoinositide 3-kinase...

View articletitled, Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?

Articles

Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis

K.E. Cosker, B.J. Eickholt

Biochem Soc Trans (2007) 35 (2): 207–210.

https://doi.org/10.1042/BST0350207

Published: 20 March 2007

... neurotrophin phosphoinositide 3-kinase (PI3K) signalling The correct wiring of the nervous system depends on each neuron extending a single long axon and multiple dendrites to reach their appropriate targets. At their targets, neuronal processes form synapses where signal transduction takes place...

View articletitled, Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis

Articles

Exploring the potential of PI3K inhibitors for inflammation and cancer

T. Crabbe

Biochem Soc Trans (2007) 35 (2): 253–256.

https://doi.org/10.1042/BST0350253

Published: 20 March 2007

... selectivity phosphoinositide 3-kinase (PI3K) phosphoinositide 3-kinase inhibitor Modulation of the intracellular PIP 3 (phosphatidylinositol 3,4,5-trisphosphate) concentration is well established as a mechanism by which eukaryotic cells are able to respond to changes in their environment. A family...

View articletitled, Exploring the potential of PI3K inhibitors for inflammation and cancer

Articles

Role of class II phosphoinositide 3-kinase in cell signalling

M. Falasca, T. Maffucci

Biochem Soc Trans (2007) 35 (2): 211–214.

https://doi.org/10.1042/BST0350211

Published: 20 March 2007

... factor) receptors has also been reported, suggesting that both enzymes might have a role in such signalling pathways [ 39 ]. In addition PI3K-C2β has also been reported to associate with the SCF (stem cell factor) receptor [ 40 ]. cell signalling lysophosphatidic acid phosphoinositide 3-kinase...

View articletitled, Role of class II phosphoinositide 3-kinase in cell signalling

Articles

FOXO transcription factors: key regulators of cell fate

E.W.-F. Lam, R.E. Francis, M. Petkovic

Biochem Soc Trans (2006) 34 (5): 722–726.

https://doi.org/10.1042/BST0340722

Published: 25 October 2006

... resistance. 1 To whom correspondence should be addressed (email [email protected] ). 30 6 2006 © 2006 The Biochemical Society 2006 cell fate forkhead box O (FOXO) phosphoinositide 3-kinase (PI3K) phosphorylation tumour The mammalian FOXO family of transcription...

View articletitled, FOXO transcription factors: key regulators of cell fate

Articles

Phosphoinositide 3-kinase signalling and FoxO transcription factors in rheumatoid arthritis

K.A. Reedquist, J. Ludikhuize, P.P. Tak

Biochem Soc Trans (2006) 34 (5): 727–730.

https://doi.org/10.1042/BST0340727

Published: 25 October 2006

... The Biochemical Society 2006 fibroblast-like synoviocyte forkhead box O (FoxO) inflammation p53 up-regulated modulator of apoptosis (PUMA) phosphoinositide 3-kinase (PI3K) rheumatoid arthritis RA is a common, progressive, destructive inflammatory disease characterized by improper activation...

View articletitled, Phosphoinositide 3-kinase signalling and FoxO transcription factors in rheumatoid arthritis

Articles

FOXOs in the maintenance of vascular homoeostasis

J.-H. Paik

Biochem Soc Trans (2006) 34 (5): 731–734.

https://doi.org/10.1042/BST0340731

Published: 25 October 2006

...) homoeostasis phosphoinositide 3-kinase (PI3K) vascular cell type The FoxO family of transcription factors belong to the winged helix or forkhead box class of transcription factors [ 1 ], which have been identified in organisms ranging from yeast to human. Mice and humans possess four known FoxO...

View articletitled, FOXOs in the maintenance of vascular homoeostasis

Articles

Regulation of RalA GTPase by phosphatidylinositol 3-kinase as visualized by FRET probes

H. Yoshizaki, K. Aoki, T. Nakamura, M. Matsuda

Biochem Soc Trans (2006) 34 (5): 851–854.

https://doi.org/10.1042/BST0340851

Published: 25 October 2006

.... Alessi D.R. van Aalten D.M. EMBO J. 2004 23 3918 3928 Akt fluorescence resonance energy transfer (FRET) green fluorescent protein (GFP) imaging phosphoinositide 3-kinase (PI3K) Ral Small GTPases function as critical molecular switches in a variety of signal transduction...

View articletitled, Regulation of RalA GTPase by phosphatidylinositol 3-kinase as visualized by FRET probes

Articles

TOPs and their regulation

T.L. Hamilton, M. Stoneley, K.A. Spriggs, M. Bushell

Biochem Soc Trans (2006) 34 (1): 12–16.

https://doi.org/10.1042/BST0340012

Published: 20 January 2006

... target of rapamycin (mTOR) mRNA phosphoinositide 3-kinase (PI3K) protein synthesis translation Comparison of the data from the different polysome profiling studies suggests that some TOP mRNAs can be subject to more than one level of translational regulation; perhaps the most striking example...

View articletitled, TOPs and their regulation

Articles

Leptin: a potential cognitive enhancer?

J. Harvey, L.J. Shanley, D. O'Malley, A.J. Irving

Biochem Soc Trans (2005) 33 (5): 1029–1032.

https://doi.org/10.1042/BST0331029

Published: 26 October 2005

... (email [email protected] ). 5 5 2005 © 2005 The Biochemical Society 2005 cognitive enhancer hippocampus leptin N -methyl- D -aspartate receptor (NMDA receptor) synaptic plasticity phosphoinositide 3-kinase (PI3K) AMPA α-amino-3-hydroxy-5-methyl-4...

View articletitled, Leptin: a potential cognitive enhancer?

Articles

Centaurin-α 1 and KIF13B kinesin motor protein interaction in ARF6 signalling

V. Kanamarlapudi

Biochem Soc Trans (2005) 33 (6): 1279–1281.

https://doi.org/10.1042/BST0331279

Published: 26 October 2005

... (University College London, U.K.), Y. Goda (University College London, U.K.), R. Insall (Birmingham, U.K.) and M. Wakelam (Birmingham, U.K.). ADP-ribosylation factor 6 (ARF6) centaurin-α 1 KIF13B membrane trafficking phosphoinositide 3-kinase (PI3K) PtdIns(3,4,5) P 3 The ARFs (ADP...

View articletitled, Centaurin-α 1 and KIF13B kinesin motor protein interaction in ARF6 signalling

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Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells

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Biochem Soc Trans (2005) 33 (6): 1522–1525.

https://doi.org/10.1042/BST0331522

Published: 26 October 2005

...) phosphoinositide 3-kinase (PI3K) pluripotency teratoma tumorigenicity Embryonic stem (ES) cells were first established from the inner cell mass of mouse blastocysts in 1981 [ 1 , 2 ]. ES cells can proliferate infinitely while maintaining pluripotency, the ability to differentiate into any kind of cells...

View articletitled, Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells

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The regulation of cell migration by PTEN

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Biochem Soc Trans (2005) 33 (6): 1507–1508.

https://doi.org/10.1042/BST0331507

Published: 26 October 2005

... in the regulation of cell migration. 1 To whom correspondence should be addressed (email [email protected] ). 4 7 2005 © 2005 The Biochemical Society 2005 cell migration chemoattractant lipid phosphatase phosphoinositide 3-kinase (PI3K) PtdIns(3,4,5) P 3 phosphatase...

View articletitled, The regulation of cell migration by PTEN

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Analysis of insulin signalling by RNAi-based gene silencing

Q.L. Zhou, J.G. Park, Z.Y. Jiang, J.J. Holik, P. Mitra, S. Semiz, A. Guilherme, A.M. Powelka, X. Tang, J. Virbasius, M.P. Czech

Biochem Soc Trans (2004) 32 (5): 817–821.

https://doi.org/10.1042/BST0320817

Published: 26 October 2004

... ). 30 7 2004 © 2004 The Biochemical Society 2004 gene silencing glucose insulin signalling phosphoinositide 3-kinase (PI3K) phospholipase Cγ protein kinase Cλ/ζ siRNA Insulin signalling is a required mechanism for normal glucose homoeostasis in humans, and loss of either insulin...

View articletitled, Analysis of insulin signalling by RNAi-based gene silencing

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