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Keyword: phosphoinositide 3-kinase (PI3K)
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Articles
Biochem Soc Trans (2015) 43 (5): 1085–1088.
Published: 09 October 2015
...@ualg.pt. 7 5 2015 © 2015 Authors; published by Portland Press Limited 2015 biomarker FOXO (forkhead box protein O) melanoma phosphoinositide 3-kinase (PI3K) tribbles TRIB2 (tribbles homolog 2) Tribbles was identified 15 years ago in three independent screens as a key...
Articles
Biochem Soc Trans (2015) 43 (4): 611–620.
Published: 03 August 2015
... proteasomal degradation via the cullin-3 (Cul3)–RING ubiquitin ligase CRL Keap1 . In the latter case, we speculate that growth factors increase the stability of Nrf2 by stimulating phosphoinositide 3-kinase (PI3K)−protein kinase B (PKB)/Akt signalling, which in turn results in inhibitory phosphorylation of...
Articles
Biochem Soc Trans (2014) 42 (5): 1343–1348.
Published: 18 September 2014
... mimetic phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatidylinositol phosphoinositide 3-kinase (PI3K) Research into phosphoinositide-dependent signalling has been around for many decades and has now become a staple ingredient of many important mechanisms governing...
Articles
Biochem Soc Trans (2014) 42 (5): 1349–1355.
Published: 18 September 2014
... should be addressed (email atoker@bidmc.harvard.edu ). 30 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Akt breast cancer cancer phosphoinositide 3-kinase (PI3K) phosphorylation signalling substrate The serine/threonine protein kinase Akt, also...
Articles
Biochem Soc Trans (2014) 42 (5): 1378–1382.
Published: 18 September 2014
...Tania Maffucci; Marco Falasca In the last few years, an increased attention to class II isoforms of phosphoinositide 3-kinase (PI3K) has emerged, mainly fuelled by evidence suggesting a distinct non-redundant role for these enzymes compared with other PI3Ks. Despite this renewed interest, many...
Articles
Biochem Soc Trans (2014) 42 (4): 733–741.
Published: 11 August 2014
... To whom correspondence should be addressed (email bentires@fmi.ch ). 23 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 breast cancer drug resistance phosphoinositide 3-kinase (PI3K) signalling targeted therapy The PI3K (phosphoinositide 3...
Articles
Biochem Soc Trans (2014) 42 (4): 798–803.
Published: 11 August 2014
... (ARF) murine double minute 2 (MDM2) phosphoinositide 3-kinase (PI3K) TP53 The PI3K (phosphoinositide 3-kinase)/Akt pathway is an essential pathway that mediates cellular survival of proliferating cells. Activating mutations, amplifications and rearrangements in the upstream members of the...
Articles
Biochem Soc Trans (2014) 42 (1): 120–124.
Published: 23 January 2014
... be addressed (email j.flanagan@auckland.ac.nz ). 11 11 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer H1047R mutant p110α phosphoinositide 3-kinase (PI3K) The class I PI3Ks (phosphoinositide 3-kinases) are a family of closely related...
Articles
Biochem Soc Trans (2014) 42 (1): 11–24.
Published: 23 January 2014
... within the greater context of the field. 1 email k.y.clark@dundee.ac.uk 26 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 inhibitor of nuclear factor κB kinase (IKK) innate immunity mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase...
Articles
Biochem Soc Trans (2012) 40 (1): 240–245.
Published: 19 January 2012
... whom correspondence should be addressed (email augustin.j.amour@gsk.com ). 26 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 allergic asthma B-cell cytokine mast cell phosphoinositide 3-kinase (PI3K) T-cell Asthma is a common respiratory...
Articles
Biochem Soc Trans (2012) 40 (1): 139–146.
Published: 19 January 2012
... 5 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Akt cross-talk mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K) Ras A cell in an organism is immersed in an ocean of growth factors and hormones, yet how signalling networks...
Articles
Biochem Soc Trans (2011) 39 (2): 451–455.
Published: 22 March 2011
... benefit in cancer patients. 1 email echeverria@sanofi-aventis.com 25 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cancer mammalian target of rapamycin inhibitor (mTOR inhibitor) phosphoinositide 3-kinase (PI3K) rapalogue targeted therapy...
Articles
Biochem Soc Trans (2011) 39 (2): 674–678.
Published: 22 March 2011
... Journal compilation © 2011 Biochemical Society 2011 cell cycle embryonic stem cell glycogen synthase kinase 3 (GSK-3) phosphoinositide 3-kinase (PI3K) pluripotency proliferation self-renewal ESCs are derived from early pre-implantation embryos and, when cultured appropriately, can be...
Articles
Biochem Soc Trans (2009) 37 (4): 615–626.
Published: 22 July 2009
... component of the catalytic cycle of the enzymes. 1 To whom correspondence should be addressed (email rlw@mrc-lmb.cam.ac.uk ). 25 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer p85 p110 phosphoinositide 3-kinase (PI3K) phosphoinositide 3,4,5...
Articles
Biochem Soc Trans (2009) 37 (1): 217–222.
Published: 20 January 2009
... (mTORC) phosphoinositide-dependent kinase 1 (PDK1) phosphoinositide 3-kinase (PI3K) Rheb tuberous sclerosis complex (TSC) Dysregulation of the serine/threonine protein kinase Akt [or PKB (protein kinase B)] underlies the pathology of a number of common human diseases, such as cancer and...
Articles
Biochem Soc Trans (2009) 37 (1): 173–177.
Published: 20 January 2009
... epidermal growth factor receptor (EGFR) endosomal sorting complex required for transport (ESCRT) multivesicular body (MVB) phosphoinositide 3-kinase (PI3K) protein tyrosine phosphatase 1B (PTP1B) EGF (epidermal growth factor) binding to the EGFR (EGF receptor) promotes increased RTK (receptor...
Articles
Biochem Soc Trans (2009) 37 (1): 265–272.
Published: 20 January 2009
... discussed. 1 To whom correspondence should be addressed (email sauveur-michel.maira@novartis.com ). 2 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer mammalian target of rapamycin (mTOR) phosphoinositide 3-kinase (PI3K) small-molecule kinase...
Articles
Biochem Soc Trans (2007) 35 (5): 1109–1113.
Published: 25 October 2007
... lymph node. 1 To whom correspondence should be addressed (email dfruman@uci.edu ). 10 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chemokine chemotaxis leukaemia lymphocyte phosphoinositide 3-kinase (PI3K) two-photon microscopy...
Articles
Biochem Soc Trans (2007) 35 (5): 1168–1170.
Published: 25 October 2007
... P2X 7 phosphoinositide 3-kinase (PI3K) reactive nitrogen species reactive oxygen species It is well established that ATP acts as a key extracellular signalling molecule that is implicated in numerous cellular processes from synaptic transmission to inflammation [ 1 ]. Extracellular ATP...
Articles
Biochem Soc Trans (2007) 35 (2): 186–187.
Published: 20 March 2007
... whom correspondence should be addressed (email bgh1@st-andrews.ac.uk ). 15 12 2006 © 2007 The Biochemical Society 2007 Akt antiviral drug influenza A virus NS1 protein phosphoinositide 3-kinase (PI3K) p85 Both seasonal and pandemic outbreaks of influenza A virus pose a...
Articles
Biochem Soc Trans (2007) 35 (2): 253–256.
Published: 20 March 2007
... Society 2007 cancer DNA-dependent protein kinase (DNA-PK) inflammation isoform selectivity phosphoinositide 3-kinase (PI3K) phosphoinositide 3-kinase inhibitor Modulation of the intracellular PIP 3 (phosphatidylinositol 3,4,5-trisphosphate) concentration is well established as a...
Articles
Biochem Soc Trans (2007) 35 (2): 211–214.
Published: 20 March 2007
... more answers. 1 To whom correspondence should be addressed (email m.falasca@ucl.ac.uk ). 23 10 2006 © 2007 The Biochemical Society 2007 cell signalling lysophosphatidic acid phosphoinositide 3-kinase (PI3K) phosphatidylinositol 3,4,5-trisphosphate PI3Ks are a...
Articles
Biochem Soc Trans (2007) 35 (2): 277–280.
Published: 20 March 2007
... from its role in the myeloid lineage. 1 To whom correspondence should be addressed (email geoffrey.gloire@ulg.ac.be ). 9 9 2006 © 2007 The Biochemical Society 2007 apoptosis cell proliferation nuclear factor κB (NF-κB) phosphoinositide 3-kinase (PI3K) Src homology 2...
Articles
Biochem Soc Trans (2007) 35 (2): 257–259.
Published: 20 March 2007
... homologue deleted on chromosome 10 (PTEN) phosphatidylinositol 3,4,5-trisphosphate phosphoinositide 3-kinase (PI3K) vanadate The key event in glucose signalling is the activation of GS (glycogen synthase) and increased glucose uptake, causing the conversion of blood glucose into muscle glycogen...
Articles
Biochem Soc Trans (2007) 35 (2): 215–218.
Published: 20 March 2007
... pathological situations. 1 To whom correspondence should be addressed (email tsasaki@med.akita-u.ac.jp ). 4 12 2006 © 2007 The Biochemical Society 2007 lipid product neutrophil phosphatidylinositol 3,4,5-trisphosphate phosphoinositide 3-kinase (PI3K) Src homology 2-containing...
Articles
Biochem Soc Trans (2007) 35 (2): 167–171.
Published: 20 March 2007
..., we review the role of PI3Ks in T-cell development and function. 1 To whom correspondence should be addressed (email klaus.okkenhaug@bbsrc.ac.uk ). 17 11 2006 © 2007 The Biochemical Society 2007 colitis forkhead box O (Foxo) p110δ phosphoinositide 3-kinase (PI3K) T-cell...
Articles
Biochem Soc Trans (2007) 35 (2): 239–241.
Published: 20 March 2007
... Biochemical Society 2007 autophagy beclin-1 mammalian target of rapamycin (mTOR) phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34) yeast Vps34 was cloned from Saccharomyces cerevisiae by Herman and Emr [ 1 ], and was first described as a gene essential for the sorting...
Articles
Biochem Soc Trans (2007) 35 (2): 193–198.
Published: 20 March 2007
... paper. 1 To whom correspondence should be addressed (email S.G.Ward@bath.ac.uk ). 20 11 2006 © 2007 The Biochemical Society 2007 cell migration chemokine GTPase phosphoinositide 3-kinase (PI3K) protein kinase C (PKC) T-lymphocyte Trafficking of T-lymphocytes in...
Articles
Biochem Soc Trans (2007) 35 (2): 242–244.
Published: 20 March 2007
... addressed (email Backer@aecom.yu.edu ). 23 10 2006 © 2007 The Biochemical Society 2007 adaptor-binding domain (ABD) Breakpoint Cluster Region (BCR) domain structure p85 phosphoinositide 3-kinase (PI3K) Src homology 2 domain (SH2 domain) PI3Ks are critical regulators of...
Articles
Biochem Soc Trans (2007) 35 (2): 177–180.
Published: 20 March 2007
... autoimmunity knockout mouse phosphoinositide 3-kinase (PI3K) regulatory T-cell (Treg) T-cell thymocyte Due to space constraints, I refer the reader to other reviews with a detailed description of PI3K isoform structure, regulation and activation mechanisms in T-cells [ 1 , 2 ]. To briefly...
Articles
Biochem Soc Trans (2007) 35 (2): 222–224.
Published: 20 March 2007
... Society 2007 cell cycle cell division cycle 42 (Cdc42) cyclin B cytokinesis phosphoinositide 3-kinase (PI3K) septin Cell division ends with cytokinesis, the separation of the mother cell cytosol between the two daughter cells. A large number of proteins, some of which have been identified...
Articles
Biochem Soc Trans (2007) 35 (2): 199–203.
Published: 20 March 2007
..., based on possible effects of p85 deletion on phosphatases acting on PIP 3 , are discussed. 1 To whom correspondence should be addressed (email bartvanh@ludwig.ucl.ac.uk ). 21 11 2006 © 2007 The Biochemical Society 2007 insulin p85 phosphoinositide 3-kinase (PI3K...
Articles
Biochem Soc Trans (2007) 35 (2): 181–182.
Published: 20 March 2007
... for phosphotyrosine and 3-phosphoinositides 1 (Bam32/DAPP1) B-lymphocyte phosphoinositide 3-kinase (PI3K) pleckstrin homology domain (PH domain) Bam32 (B-cell adaptor molecule of 32 kDa)/DAPP1 (dual adaptor for phosphotyrosine and 3-phosphoinositides 1) is a 32 kDa signalling protein...
Articles
Biochem Soc Trans (2007) 35 (2): 245–249.
Published: 20 March 2007
... mammalian target of rapamycin (mTOR) p110 phosphatidylinositol phosphoinositide 3-kinase (PI3K) PI3K (phosphoinositide 3-kinase) is activated by receptor tyrosine kinases and other cell-surface receptors to synthesize the lipid second messenger PIP 3 (phosphatidylinositol-3,4,5-trisphosphate...
Articles
Biochem Soc Trans (2007) 35 (2): 225–228.
Published: 20 March 2007
...) phosphoinositide 3-kinase (PI3K) pluripotency self-renewal ES cell lines exhibit the unique property of pluripotency, i.e. the ability to differentiate into all cell lineages comprising the adult organism [ 1 , 2 ]. Pluripotency is underpinned by ES cell self-renewal, the term given to the symmetrical...
Articles
Biochem Soc Trans (2007) 35 (2): 204–206.
Published: 20 March 2007
... be addressed (email jdoukas@targegen.com ). 30 10 2006 © 2007 The Biochemical Society 2007 inflammation ischaemia myocardial infarction oedema phosphoinositide 3-kinase (PI3K) MI (myocardial infarction) represents the heart's attempt to manage an I/R (ischaemia...
Articles
Biochem Soc Trans (2007) 35 (2): 183–185.
Published: 20 March 2007
... cytotoxicity lymphoma natural killer cell (NK cell) p110δ phosphoinositide 3-kinase (PI3K) tumour cell NK cells (natural killer cells) are large granular lymphocytes, distinct from B- and T-cells, in that they are able to reject tumour cells without prior stimulation. NK cell activation results...
Articles
Biochem Soc Trans (2007) 35 (2): 229–230.
Published: 20 March 2007
... © 2007 The Biochemical Society 2007 growth factor phospholipase C (PLC) pleckstrin homology domain (PH domain) phosphoinositide 3-kinase (PI3K) Src homology 2 domain (SH2 domain) tyrosine phosphorylation PtdIns(4,5) P 2 is a minor phospholipid component of cell membrane (∼0.5% of total...
Articles
Biochem Soc Trans (2007) 35 (2): 250–252.
Published: 20 March 2007
... cytokines and growth factors are able to control these pleiotropic responses. 1 To whom correspondence should be addressed (email mark.guthridge@imvs.sa.gov.au ). 26 10 2006 © 2007 The Biochemical Society 2007 14-3-3 protein cytokine growth factor phosphoinositide 3-kinase...
Articles
Biochem Soc Trans (2007) 35 (2): 207–210.
Published: 20 March 2007
... neuronal morphology neurotrophin phosphoinositide 3-kinase (PI3K) signalling The correct wiring of the nervous system depends on each neuron extending a single long axon and multiple dendrites to reach their appropriate targets. At their targets, neuronal processes form synapses where signal...
Articles
Biochem Soc Trans (2006) 34 (5): 722–726.
Published: 25 October 2006
... resistance. 1 To whom correspondence should be addressed (email eric.lam@imperial.ac.uk ). 30 6 2006 © 2006 The Biochemical Society 2006 cell fate forkhead box O (FOXO) phosphoinositide 3-kinase (PI3K) phosphorylation tumour The PI3K signal transduction pathway...
Articles
Biochem Soc Trans (2006) 34 (5): 727–730.
Published: 25 October 2006
... Biochemical Society 2006 fibroblast-like synoviocyte forkhead box O (FoxO) inflammation p53 up-regulated modulator of apoptosis (PUMA) phosphoinositide 3-kinase (PI3K) rheumatoid arthritis RA is a common, progressive, destructive inflammatory disease characterized by improper activation...
Articles
Biochem Soc Trans (2006) 34 (5): 731–734.
Published: 25 October 2006
... angiogenesis forkhead box O (FOXO) homoeostasis phosphoinositide 3-kinase (PI3K) vascular cell type The FoxO family of transcription factors belong to the winged helix or forkhead box class of transcription factors [ 1 ], which have been identified in organisms ranging from yeast to human. Mice and...
Articles
Biochem Soc Trans (2006) 34 (5): 851–854.
Published: 25 October 2006
... protein (GFP) imaging phosphoinositide 3-kinase (PI3K) Ral Small GTPases function as critical molecular switches in a variety of signal transduction cascades. Among them, Rho family GTPases function primarily as critical molecular switches for cytoskeletal rearrangement, whereas Ras family...
Articles
Biochem Soc Trans (2006) 34 (1): 12–16.
Published: 20 January 2006
... target of rapamycin (mTOR) mRNA phosphoinositide 3-kinase (PI3K) protein synthesis translation What is a TOP (terminal oligopyrimidine tract) message? The vast majority of eukaryotic mRNAs have a cap structure at their 5′ ends, normally followed by an A residue ( Figure 1 ) [ 1 ]. However...
Articles
Biochem Soc Trans (2005) 33 (6): 1507–1508.
Published: 26 October 2005
... in the regulation of cell migration. 1 To whom correspondence should be addressed (email n.r.leslie@dundee.ac.uk ). 4 7 2005 © 2005 The Biochemical Society 2005 cell migration chemoattractant lipid phosphatase phosphoinositide 3-kinase (PI3K) PtdIns(3,4,5) P 3...
Articles
Biochem Soc Trans (2005) 33 (6): 1522–1525.
Published: 26 October 2005
...) phosphoinositide 3-kinase (PI3K) pluripotency teratoma tumorigenicity Embryonic stem (ES) cells were first established from the inner cell mass of mouse blastocysts in 1981 [ 1 , 2 ]. ES cells can proliferate infinitely while maintaining pluripotency, the ability to differentiate into any kind of cells...
Articles
Biochem Soc Trans (2005) 33 (6): 1279–1281.
Published: 26 October 2005
...@bristol.ac.uk 4 7 2005 © 2005 The Biochemical Society 2005 ADP-ribosylation factor 6 (ARF6) centaurin-α 1 KIF13B membrane trafficking phosphoinositide 3-kinase (PI3K) PtdIns(3,4,5) P 3 The ARFs (ADP-ribosylation factors) are Ras-related small GTPases that regulate intracellular...
Articles
Biochem Soc Trans (2005) 33 (5): 1029–1032.
Published: 26 October 2005
... (email j.z.harvey@dundee.ac.uk ). 5 5 2005 © 2005 The Biochemical Society 2005 cognitive enhancer hippocampus leptin N -methyl- D -aspartate receptor (NMDA receptor) synaptic plasticity phosphoinositide 3-kinase (PI3K) It is well documented that the hormone leptin plays...
Articles
Biochem Soc Trans (2004) 32 (5): 817–821.
Published: 26 October 2004
... regulator of this pathway. 1 To whom correspondence should be addressed (email Michael.Czech@umassmed.edu ). 30 7 2004 © 2004 The Biochemical Society 2004 gene silencing glucose insulin signalling phosphoinositide 3-kinase (PI3K) phospholipase Cγ protein kinase Cλ/ζ siRNA...