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Keywords: phosphoinositide 3-kinase (PI3K)
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Articles
Biochem Soc Trans (2015) 43 (5): 1085–1088.
Published: 09 October 2015
... 144 10.1038/cdd.2014.133 25168244 1 email walink@ualg.pt. 7 5 2015 © 2015 Authors; published by Portland Press Limited 2015 biomarker FOXO (forkhead box protein O) melanoma phosphoinositide 3-kinase (PI3K) tribbles TRIB2 (tribbles homolog 2) Tribbles...
Articles
Biochem Soc Trans (2015) 43 (4): 611–620.
Published: 03 August 2015
... degradation via the cullin-3 (Cul3)–RING ubiquitin ligase CRL Keap1 . In the latter case, we speculate that growth factors increase the stability of Nrf2 by stimulating phosphoinositide 3-kinase (PI3K)−protein kinase B (PKB)/Akt signalling, which in turn results in inhibitory phosphorylation of glycogen...
Articles
Biochem Soc Trans (2014) 42 (5): 1378–1382.
Published: 18 September 2014
...Tania Maffucci; Marco Falasca In the last few years, an increased attention to class II isoforms of phosphoinositide 3-kinase (PI3K) has emerged, mainly fuelled by evidence suggesting a distinct non-redundant role for these enzymes compared with other PI3Ks. Despite this renewed interest, many...
Articles
Biochem Soc Trans (2014) 42 (5): 1349–1355.
Published: 18 September 2014
... be addressed (email atoker@bidmc.harvard.edu ). 30 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Akt breast cancer cancer phosphoinositide 3-kinase (PI3K) phosphorylation signalling substrate The serine/threonine protein kinase Akt, also known...
Articles
Biochem Soc Trans (2014) 42 (5): 1343–1348.
Published: 18 September 2014
..., phosphoinositide 3-kinases (PI3Ks) became a focal point of attention, with many investigators elucidating its role in cellular processes controlling disease development and human health (for a review, see [ 10 ]). Research into PI3K-dependent signalling was very much aided by the almost simultaneous discovery...
Articles
Biochem Soc Trans (2014) 42 (4): 798–803.
Published: 11 August 2014
... (ARF) murine double minute 2 (MDM2) phosphoinositide 3-kinase (PI3K) TP53 The PI3K (phosphoinositide 3-kinase)/Akt pathway is an essential pathway that mediates cellular survival of proliferating cells. Activating mutations, amplifications and rearrangements in the upstream members...
Articles
Biochem Soc Trans (2014) 42 (4): 733–741.
Published: 11 August 2014
... ]. As expected, BYL719 seems to be well tolerated with manageable side effects such as hyperglycaemia [ 28 ], nausea, vomiting, diarrhoea and/or decreased appetite. breast cancer drug resistance phosphoinositide 3-kinase (PI3K) signalling targeted therapy The PI3K (phosphoinositide 3...
Articles
Biochem Soc Trans (2014) 42 (1): 11–24.
Published: 23 January 2014
... within the greater context of the field. 1 email k.y.clark@dundee.ac.uk 26 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 inhibitor of nuclear factor κB kinase (IKK) innate immunity mitogen-activated protein kinase (MAPK) phosphoinositide 3...
Articles
Biochem Soc Trans (2014) 42 (1): 120–124.
Published: 23 January 2014
... Journal compilation © 2014 Biochemical Society 2014 cancer H1047R mutant p110α phosphoinositide 3-kinase (PI3K) The class I PI3Ks (phosphoinositide 3-kinases) are a family of closely related enzymes that are among the first level of cell signalling molecules regulated by tyrosine kinases...
Articles
Biochem Soc Trans (2012) 40 (1): 240–245.
Published: 19 January 2012
... Clin. Immunol. 2010 125 1146 1153 allergic asthma B-cell cytokine mast cell phosphoinositide 3-kinase (PI3K) T-cell Asthma is a common respiratory disease. It has been estimated that between 7 and 10% of the world's population are affected [ 1 ]. The number of sufferers has...
Articles
Biochem Soc Trans (2012) 40 (1): 139–146.
Published: 19 January 2012
... 5 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Akt cross-talk mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K) Ras A cell in an organism is immersed in an ocean of growth factors and hormones, yet how signalling networks...
Articles
Biochem Soc Trans (2011) 39 (2): 451–455.
Published: 22 March 2011
... in cancer patients. 1 email echeverria@sanofi-aventis.com 25 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cancer mammalian target of rapamycin inhibitor (mTOR inhibitor) phosphoinositide 3-kinase (PI3K) rapalogue targeted therapy mTOR...
Articles
Biochem Soc Trans (2011) 39 (2): 674–678.
Published: 22 March 2011
... cell cycle embryonic stem cell glycogen synthase kinase 3 (GSK-3) phosphoinositide 3-kinase (PI3K) pluripotency proliferation self-renewal Our work, alongside that of others, has also implicated PI3K-dependent signalling in the control of mESC self-renewal. We were the first to suggest...
Articles
Biochem Soc Trans (2009) 37 (4): 615–626.
Published: 22 July 2009
... of the catalytic cycle of the enzymes. 1 To whom correspondence should be addressed (email rlw@mrc-lmb.cam.ac.uk ). 25 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer p85 p110 phosphoinositide 3-kinase (PI3K) phosphoinositide 3,4,5-trisphosphate...
Articles
Biochem Soc Trans (2009) 37 (1): 265–272.
Published: 20 January 2009
... cancer mammalian target of rapamycin (mTOR) phosphoinositide 3-kinase (PI3K) small-molecule kinase inhibitor Activation of the PI3K (phosphoinositide 3-kinase) pathway is a recurrent feature observed in human tumours. Findings accumulated over the past 20 years have clearly underlined the role...
Articles
Biochem Soc Trans (2009) 37 (1): 217–222.
Published: 20 January 2009
... (mTORC) phosphoinositide-dependent kinase 1 (PDK1) phosphoinositide 3-kinase (PI3K) Rheb tuberous sclerosis complex (TSC) Dysregulation of the serine/threonine protein kinase Akt [or PKB (protein kinase B)] underlies the pathology of a number of common human diseases, such as cancer...
Articles
Biochem Soc Trans (2009) 37 (1): 173–177.
Published: 20 January 2009
... epidermal growth factor receptor (EGFR) endosomal sorting complex required for transport (ESCRT) multivesicular body (MVB) phosphoinositide 3-kinase (PI3K) protein tyrosine phosphatase 1B (PTP1B) EGF (epidermal growth factor) binding to the EGFR (EGF receptor) promotes increased RTK (receptor...
Articles
Biochem Soc Trans (2007) 35 (5): 1109–1113.
Published: 25 October 2007
... dfruman@uci.edu ). 10 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chemokine chemotaxis leukaemia lymphocyte phosphoinositide 3-kinase (PI3K) two-photon microscopy Class IA and IB PI3K have similar catalytic subunits but distinct regulatory subunits...
Articles
Biochem Soc Trans (2007) 35 (5): 1168–1170.
Published: 25 October 2007
... oxidase P2X 7 phosphoinositide 3-kinase (PI3K) reactive nitrogen species reactive oxygen species It is well established that ATP acts as a key extracellular signalling molecule that is implicated in numerous cellular processes from synaptic transmission to inflammation [ 1 ]. Extracellular...
Articles
Biochem Soc Trans (2007) 35 (2): 193–198.
Published: 20 March 2007
... paper. 1 To whom correspondence should be addressed (email S.G.Ward@bath.ac.uk ). 20 11 2006 © 2007 The Biochemical Society 2007 cell migration chemokine GTPase phosphoinositide 3-kinase (PI3K) protein kinase C (PKC) T-lymphocyte Trafficking of T-lymphocytes...
Articles
Biochem Soc Trans (2007) 35 (2): 242–244.
Published: 20 March 2007
... be addressed (email Backer@aecom.yu.edu ). 23 10 2006 © 2007 The Biochemical Society 2007 adaptor-binding domain (ABD) Breakpoint Cluster Region (BCR) domain structure p85 phosphoinositide 3-kinase (PI3K) Src homology 2 domain (SH2 domain) PI3Ks are critical regulators...
Articles
Biochem Soc Trans (2007) 35 (2): 222–224.
Published: 20 March 2007
... The Biochemical Society 2007 cell cycle cell division cycle 42 (Cdc42) cyclin B cytokinesis phosphoinositide 3-kinase (PI3K) septin Cell division ends with cytokinesis, the separation of the mother cell cytosol between the two daughter cells. A large number of proteins, some of which have been...
Articles
Biochem Soc Trans (2007) 35 (2): 199–203.
Published: 20 March 2007
..., based on possible effects of p85 deletion on phosphatases acting on PIP 3 , are discussed. 1 To whom correspondence should be addressed (email bartvanh@ludwig.ucl.ac.uk ). 21 11 2006 © 2007 The Biochemical Society 2007 insulin p85 phosphoinositide 3-kinase (PI3K...
Articles
Biochem Soc Trans (2007) 35 (2): 245–249.
Published: 20 March 2007
... mammalian target of rapamycin (mTOR) p110 phosphatidylinositol phosphoinositide 3-kinase (PI3K) PI3K (phosphoinositide 3-kinase) is activated by receptor tyrosine kinases and other cell-surface receptors to synthesize the lipid second messenger PIP 3 (phosphatidylinositol-3,4,5-trisphosphate...
Articles
Biochem Soc Trans (2007) 35 (2): 225–228.
Published: 20 March 2007
... detailed discussion see [ 24 ]. bone morphogenetic protein (BMP) embryonic stem cell (ES cell) phosphoinositide 3-kinase (PI3K) pluripotency self-renewal ES cell lines exhibit the unique property of pluripotency, i.e. the ability to differentiate into all cell lineages comprising the adult...
Articles
Biochem Soc Trans (2007) 35 (2): 229–230.
Published: 20 March 2007
... © 2007 The Biochemical Society 2007 growth factor phospholipase C (PLC) pleckstrin homology domain (PH domain) phosphoinositide 3-kinase (PI3K) Src homology 2 domain (SH2 domain) tyrosine phosphorylation PtdIns(4,5) P 2 is a minor phospholipid component of cell membrane (∼0.5...
Articles
Biochem Soc Trans (2007) 35 (2): 186–187.
Published: 20 March 2007
... To whom correspondence should be addressed (email bgh1@st-andrews.ac.uk ). 15 12 2006 © 2007 The Biochemical Society 2007 Akt antiviral drug influenza A virus NS1 protein phosphoinositide 3-kinase (PI3K) p85 Both seasonal and pandemic outbreaks of influenza A virus pose...
Articles
Biochem Soc Trans (2007) 35 (2): 211–214.
Published: 20 March 2007
... [ 3 ]. cell signalling lysophosphatidic acid phosphoinositide 3-kinase (PI3K) phosphatidylinositol 3,4,5-trisphosphate © 2007 The Biochemical Society 2007 23 10 2006 1 To whom correspondence should be addressed (email m.falasca@ucl.ac.uk ). Class II PI3Ks were...
Articles
Biochem Soc Trans (2007) 35 (2): 183–185.
Published: 20 March 2007
... cytotoxicity lymphoma natural killer cell (NK cell) p110δ phosphoinositide 3-kinase (PI3K) tumour cell No data relating to the role of any specific isoform of PI3K in NK cell biology have been published. As p110δ is specifically expressed in leucocytes, we have used p110δ-targeted mice to address its...
Articles
Biochem Soc Trans (2007) 35 (2): 250–252.
Published: 20 March 2007
... cytokines and growth factors are able to control these pleiotropic responses. 1 To whom correspondence should be addressed (email mark.guthridge@imvs.sa.gov.au ). 26 10 2006 © 2007 The Biochemical Society 2007 14-3-3 protein cytokine growth factor phosphoinositide 3-kinase...
Articles
Biochem Soc Trans (2007) 35 (2): 207–210.
Published: 20 March 2007
... neurotrophin phosphoinositide 3-kinase (PI3K) signalling The correct wiring of the nervous system depends on each neuron extending a single long axon and multiple dendrites to reach their appropriate targets. At their targets, neuronal processes form synapses where signal transduction takes place...
Articles
Biochem Soc Trans (2007) 35 (2): 253–256.
Published: 20 March 2007
.... Hemmings (Friedrich Miescher Institute for Biomedical Research, Switzerland), B. Vanhaesebroeck (Ludwig Institute for Cancer Research, U.K.), S. Ward (Bath, U.K.) and M. Welham (Bath, U.K.). cancer DNA-dependent protein kinase (DNA-PK) inflammation isoform selectivity phosphoinositide 3-kinase...
Articles
Biochem Soc Trans (2007) 35 (2): 239–241.
Published: 20 March 2007
... To whom correspondence should be addressed (email Backer@aecom.yu.edu ). 1 11 2006 © 2007 The Biochemical Society 2007 autophagy beclin-1 mammalian target of rapamycin (mTOR) phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34) yeast Vps34 was cloned from...
Articles
Biochem Soc Trans (2007) 35 (2): 277–280.
Published: 20 March 2007
... from its role in the myeloid lineage. 1 To whom correspondence should be addressed (email geoffrey.gloire@ulg.ac.be ). 9 9 2006 © 2007 The Biochemical Society 2007 apoptosis cell proliferation nuclear factor κB (NF-κB) phosphoinositide 3-kinase (PI3K) Src homology 2...
Articles
Biochem Soc Trans (2007) 35 (2): 257–259.
Published: 20 March 2007
.... Suzuki A. Mak T.W. Kahn C.R. Mol. Cell. Biol. 2005 25 1135 1145 diabetes insulin signalling phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatidylinositol 3,4,5-trisphosphate phosphoinositide 3-kinase (PI3K) vanadate The key event in glucose...
Articles
Biochem Soc Trans (2007) 35 (2): 215–218.
Published: 20 March 2007
... 37 Kishimoto H. Ohteki T. Yajima N. Kawahara K. Natsui M. Kawarasaki S. Hamada K. Horie Y. Yubo Y. Arase S. Blood 2006 doi:10.1182/blood-2006-07-038059 lipid product neutrophil phosphatidylinositol 3,4,5-trisphosphate phosphoinositide 3...
Articles
Biochem Soc Trans (2007) 35 (2): 167–171.
Published: 20 March 2007
..., we review the role of PI3Ks in T-cell development and function. 1 To whom correspondence should be addressed (email klaus.okkenhaug@bbsrc.ac.uk ). 17 11 2006 © 2007 The Biochemical Society 2007 colitis forkhead box O (Foxo) p110δ phosphoinositide 3-kinase (PI3K) T-cell...
Articles
Biochem Soc Trans (2007) 35 (2): 177–180.
Published: 20 March 2007
... of factors both T-cell-intrinsic and -extrinsic. autoimmunity knockout mouse phosphoinositide 3-kinase (PI3K) regulatory T-cell (Treg) T-cell thymocyte Due to space constraints, I refer the reader to other reviews with a detailed description of PI3K isoform structure, regulation...
Articles
Biochem Soc Trans (2007) 35 (2): 181–182.
Published: 20 March 2007
... for phosphotyrosine and 3-phosphoinositides 1 (Bam32/DAPP1) B-lymphocyte phosphoinositide 3-kinase (PI3K) pleckstrin homology domain (PH domain) Bam32 (B-cell adaptor molecule of 32 kDa)/DAPP1 (dual adaptor for phosphotyrosine and 3-phosphoinositides 1) is a 32 kDa signalling protein possessing an N...
Articles
Biochem Soc Trans (2007) 35 (2): 204–206.
Published: 20 March 2007
... be addressed (email jdoukas@targegen.com ). 30 10 2006 © 2007 The Biochemical Society 2007 inflammation ischaemia myocardial infarction oedema phosphoinositide 3-kinase (PI3K) EC endothelial cell GPCR G-protein-coupled receptor I/R ischaemia/reperfusion LAD...
Articles
Biochem Soc Trans (2006) 34 (5): 727–730.
Published: 25 October 2006
... The Biochemical Society 2006 fibroblast-like synoviocyte forkhead box O (FoxO) inflammation p53 up-regulated modulator of apoptosis (PUMA) phosphoinositide 3-kinase (PI3K) rheumatoid arthritis RA is a common, progressive, destructive inflammatory disease characterized by improper activation...
Articles
Biochem Soc Trans (2006) 34 (5): 722–726.
Published: 25 October 2006
... resistance. 1 To whom correspondence should be addressed (email eric.lam@imperial.ac.uk ). 30 6 2006 © 2006 The Biochemical Society 2006 cell fate forkhead box O (FOXO) phosphoinositide 3-kinase (PI3K) phosphorylation tumour The mammalian FOXO family of transcription...
Articles
Biochem Soc Trans (2006) 34 (5): 851–854.
Published: 25 October 2006
... regulation of the Ral by the PI3K (phosphoinositide 3-kinase)–Akt pathway. Akt fluorescence resonance energy transfer (FRET) green fluorescent protein (GFP) imaging phosphoinositide 3-kinase (PI3K) Ral Akind Akt Indicator CFP cyan fluorescent protein EGF epidermal growth...
Articles
Biochem Soc Trans (2006) 34 (5): 731–734.
Published: 25 October 2006
....). © 2006 The Biochemical Society 2006 Akt angiogenesis forkhead box O (FOXO) homoeostasis phosphoinositide 3-kinase (PI3K) vascular cell type The FoxO family of transcription factors belong to the winged helix or forkhead box class of transcription factors [ 1 ], which have been...
Articles
Biochem Soc Trans (2006) 34 (1): 12–16.
Published: 20 January 2006
... target of rapamycin (mTOR) mRNA phosphoinositide 3-kinase (PI3K) protein synthesis translation The regulation of TOP mRNAs has been studied for a number of years, and, consequently, an extensive body of literature has accumulated, focusing in particular on the signalling pathways that lie...
Articles
Biochem Soc Trans (2005) 33 (6): 1279–1281.
Published: 26 October 2005
... (University College London, U.K.), Y. Goda (University College London, U.K.), R. Insall (Birmingham, U.K.) and M. Wakelam (Birmingham, U.K.). ADP-ribosylation factor 6 (ARF6) centaurin-α 1 KIF13B membrane trafficking phosphoinositide 3-kinase (PI3K) PtdIns(3,4,5) P 3 The ARFs (ADP...
Articles
Biochem Soc Trans (2005) 33 (6): 1522–1525.
Published: 26 October 2005
...) phosphoinositide 3-kinase (PI3K) pluripotency teratoma tumorigenicity Embryonic stem (ES) cells were first established from the inner cell mass of mouse blastocysts in 1981 [ 1 , 2 ]. ES cells can proliferate infinitely while maintaining pluripotency, the ability to differentiate into any kind of cells...
Articles
Biochem Soc Trans (2005) 33 (6): 1507–1508.
Published: 26 October 2005
... in the regulation of cell migration. 1 To whom correspondence should be addressed (email n.r.leslie@dundee.ac.uk ). 4 7 2005 © 2005 The Biochemical Society 2005 cell migration chemoattractant lipid phosphatase phosphoinositide 3-kinase (PI3K) PtdIns(3,4,5) P 3 phosphatase...
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Biochem Soc Trans (2005) 33 (5): 1029–1032.
Published: 26 October 2005
... hippocampus leptin N -methyl- D -aspartate receptor (NMDA receptor) synaptic plasticity phosphoinositide 3-kinase (PI3K) It is well documented that the hormone leptin plays a key role in regulating food intake and body weight via its actions on specific hypothalamic nuclei [ 1 ]. Hypothalamic...
Articles
Biochem Soc Trans (2004) 32 (5): 781–784.
Published: 26 October 2004
... 3-kinase (PI3K) protein kinase B (PKB) signal transduction Vav Stimulation of the BCR (B-cell antigen receptor) results in the activation of protein tyrosine kinases and the recruitment of scaffold proteins leading to the assembly of a multiprotein complex, termed a signalsome...