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Keywords: phosphoproteomics
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Articles

Insulin signalling and GLUT4 trafficking in insulin resistance

Open Access
Julian van Gerwen, Amber S. Shun-Shion, Daniel J. Fazakerley
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1057–1069.
https://doi.org/10.1042/BST20221066
Published: 30 May 2023
... changes in insulin signalling and GLUT4 trafficking underpinning insulin resistance remain unclear. In this review, we highlight insights from recent unbiased phosphoproteomics studies, which have enabled a comprehensive examination of insulin signalling and have transformed our perspective on how...
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Articles

Approaches for measuring signalling plasticity in the context of resistance to targeted cancer therapies

Available to Purchase
Edmund H. Wilkes, Pedro Casado, Pedro R. Cutillas
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 791–797.
https://doi.org/10.1042/BST20140029
Published: 11 August 2014
... its pro-apoptotic effect, rendering therapy ineffective. Figure 3 The principles of KSEA applied to predicting intrinsic resistance ( A ) The phosphoproteome (represented by phosphopeptide intensities) was quantified across 15 primary AML samples. By matching each phosphopeptide to its...
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Articles

Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components

Available to Purchase
Barbara Mair, Johannes Popow, Karl Mechtler, Stefan Weitzer, Javier Martinez
Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 831–837.
https://doi.org/10.1042/BST20130025
Published: 18 July 2013
... of these authors (email [email protected] or [email protected] ). 5 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 ATP hydrolysis cleavage and polyadenylation factor I subunit (CLP1) phosphoproteomics tRNA splicing tRNA-splicing...
View articletitled, Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components
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Includes: Supplementary data