...Nordin M.J. Hanssen; Coen D.A. Stehouwer; Casper G. Schalkwijk Cardiovascular disease, caused predominantly by atherosclerotic plaque rupture, remains one of the leading causes of death. However, the mechanism of plaque rupture remains largely unknown. Recent studies have linked high metabolic...

... themselves as unstable angina, acute myocardial infarction or sudden cardiac death. The most common cause of acute coronary thrombosis is plaque rupture (in approx. 75%), notably the rupture of a thin-cap fibroatheroma [ 2 ]. These plaques typically cause only minor stenosis of the coronary lumen...

...C.L. Jackson Little is known of the relationship between plaque rupture and adaptive geometric remodelling, especially in the context of unstable atherosclerosis. We have assessed remodelling in the proximal brachiocephalic arteries of fat-fed apoE (apolipoprotein E)-knockout mice. The rate...