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Keywords: polymer physics
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Biochem Soc Trans (2021) 49 (4): 1675–1684.
Published: 20 July 2021
... inside the cell nucleus. Genome architecture is linked to vital functional purposes, yet a full comprehension of the mechanisms behind DNA folding is still far from being accomplished. Theoretical approaches based on polymer physics have been employed to understand the complexity of chromatin...
Biochem Soc Trans (2013) 41 (2): 612–615.
Published: 21 March 2013
...’ polymer physics from the study of chromosome behaviour, in particular chromatin fibres inside the nucleus would probably not behave as standard equilibrated polymer chains. But how do chromosomes fold inside the nucleus? In particular, do they truly behave as featureless random coils? Unfortunately...
Biochem Soc Trans (2013) 41 (2): 582–588.
Published: 21 March 2013
...–protein interactions. In part, this was caused by a caging effect through which one protein could interact with several DNA segments, which then slowed down its diffusive motion. Brownian dynamics simulations DNA looping facilitated diffusion polymer physics search on DNA In living cells...
Biochem Soc Trans (2013) 41 (2): 508–512.
Published: 21 March 2013
...-dimensional architecture is orchestrated. In the present article, we review the application of a model based on classical polymer physics, the strings and binders switch model, to explain the molecular mechanisms of chromatin self-organization. We explore the scenario where chromatin architecture is shaped...