...-state NMR, and cryo-electron microscopy have enabled the development of high-resolution molecular structures of these polymorphic amyloid fibrils, which are either grown in vitro or isolated from human and transgenic mouse brain tissues. This article reviews our current understanding of the structural...

.... The idea that TLRs undergo strong purifying selection provides the framework for the discussion of single nucleotide polymorphisms, many of which are associated with the incidence of infectious disease. 1 To whom correspondence should be addressed (email [email protected] ). 3 9 2007...

... human beings of almost 0.1%, most of the variation accounted for by single nucleotide polymorphisms. Variations within the regulatory region of a gene and those causing changes in the amino acid sequence of the encoded protein (either missense variations or alternative use of splice sites, leading...

...A.V. Pandey All microsomal P450s require POR (cytochrome P450 reductase) for catalytic activity. Most of the clinically used drugs are metabolized by a small number of P450s and polymorphisms in the cytochrome P450s are known to cause changes in drug metabolism. We have recently found a number...

...C.C.A. Spencer Meiotic recombination in humans is thought to occur as part of the resolution of DSBs (double-strand breaks). The repair of DSBs potentially leads to biases in DNA repair that can distort the population frequency of the alleles at single-nucleotide polymorphisms. Genome-wide...

... profiles and to modify therapeutic strategy accordingly. advanced glycation end product (AGE) complications diabetes mellitus glycation methylglyoxal polymorphism Abbreviations used: AGE, advanced glycation end products; RAGE, receptor of AGEs. 1364 Biochemical Society Transactions...

... Society held at the University of Essex, Colchester, 2–4 July 2003 4 July 2003 © 2003 Biochemical Society 2003 angiotensin-converting enzyme (ACE) angiotensin bradykinin efficiency phenotype polymorphism Abbreviations used: ACE, angiotensin-converting enzyme; RAS...

..., but it is essential that the scaffold is compatible with high aggrecan retention if a functional tissue is to be attained. 1 To whom correspondence should be addressed (e-mail [email protected] ) 7 7 2002 © 2002 Biochemical Society 2002 aggrecan polymorphism tissue engineering...