...Inés Montoya-Novoa; José Luis Gardeazábal-Torbado; Andrea Alegre-Martí; Pablo Fuentes-Prior; Eva Estébanez-Perpiñá A major mechanism to modulate the biological activities of the androgen receptor (AR) involves a growing number of post-translational modifications (PTMs). In this review we summarise...

... of the most abundant proteins in mammals. The ECM comprises of multiple different protein species and sugar polymers, with both different isoforms and post-translational modifications (PTMs) providing a large variety of microenvironments that play a key role in determining tissue structure and health...

...Jai S. Bhachoo; Alexander J. Garvin The preservation of genome integrity requires specialised DNA damage repair (DDR) signalling pathways to respond to each type of DNA damage. A key feature of DDR is the integration of numerous post-translational modification signals with DNA repair factors...

... components to ER stress-related diseases in metazoans. Post-translational modifications (PTMs) of proteins are emerging as key players in cell-fate decisions in situations of imbalanced ER proteostasis. In this review, we address PTMs orchestrating cell-fate decisions in ER stress in plants and provide...

... phospholipids post translational modification scramblase Glycerophospholipids and sphingolipids consist of a hydrophilic head and a hydrophobic tail that spontaneously form the lipid bilayer structure of membranes. Cellular membranes, including plasma and intracellular membranes, consist of lipid...

... in various physiological processes and diseases, and analyze the accumulated lines of evidence supporting diverse molecular mechanisms associated with different PANX1 activation modalities. We focus on examining recent discoveries regarding PANX1 regulations by reversible post-translational modifications...

...Jorge Ripoll-Rozada; Joshua W. C. Maxwell; Richard J. Payne; Pedro José Barbosa Pereira Tyrosine- O -sulfation is a common post-translational modification (PTM) of proteins following the cellular secretory pathway. First described in human fibrinogen, tyrosine- O -sulfation has long been associated...

... minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphorylation of inflammasome...

... deglycosylation glycosylation O -GlcNAc post translational modification protein engineering O- GlcNAc is a monosaccharide post-translational modification (PTM) installed on thousands of nucleocytoplasmic and mitochondrial proteins at multiple serine or threonine residues in eukaryotic cells [ 1...

... mass spectrometry post translational modification protein–protein interactions Correspondence: Antony J. Burton ( [email protected] ) or Tom W. Muir ( [email protected] ) 1 9 2021 5 10 2021 6 10 2021 © 2021 The Author(s). Published by Portland Press...

...Yi Zhu; Gerald W. Hart O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is actively added to and removed from thousands of intracellular proteins. As a PTM, O-GlcNAcylation tunes the functions of a protein in various ways, such as enzymatic activity...

... molecules require essential post-translational modifications (PTMs), including hydroxylation of proline and lysine residues, and subsequent attachment of glycan moieties (galactose and glucose) to specific hydroxylysine residues on procollagen alpha chains. The resulting galactosyl-hydroxylysine (Gal-Hyl...

... been shown capable of inhibiting PHD1–3 as well as a number of histone demethylases, although the biological role of these findings is unknown [ 37–39 ]. disease hydroxylation hypoxia nutrient sensing oxygenase post translational modification Beyond the HIF hydroxylases, the extent...

... and the Biochemical Society under a transformative agreement with JISC. cell metabolism inorganic polyphosphates phosphate post translational modification signalling Arthur Kornberg and Igor Kulaev spent a large part of their careers working on inorganic polyphosphate (polyP). Convinced...

... are subject of post-translational modifications such as phosphorylation, SUMOlyation, and acetylation. In this work, we summarize recent advances in the study of these immunophilins portraying them as scaffolding proteins capable to organize protein heterocomplexes, describing some of their antagonistic...