1-15 of 15
Keywords: post translational modification
Close
Sort by
Articles
Articles
Biochem Soc Trans (2024) 52 (3): 1199–1217.
Published: 23 May 2024
... of the most abundant proteins in mammals. The ECM comprises of multiple different protein species and sugar polymers, with both different isoforms and post-translational modifications (PTMs) providing a large variety of microenvironments that play a key role in determining tissue structure and health...
Articles
Biochem Soc Trans (2024) 52 (2): 773–792.
Published: 17 April 2024
...Jai S. Bhachoo; Alexander J. Garvin The preservation of genome integrity requires specialised DNA damage repair (DDR) signalling pathways to respond to each type of DNA damage. A key feature of DDR is the integration of numerous post-translational modification signals with DNA repair factors...
Articles
Articles
Biochem Soc Trans (2023) 51 (5): 1857–1869.
Published: 28 September 2023
... phospholipids post translational modification scramblase Glycerophospholipids and sphingolipids consist of a hydrophilic head and a hydrophobic tail that spontaneously form the lipid bilayer structure of membranes. Cellular membranes, including plasma and intracellular membranes, consist of lipid...
Articles
Biochem Soc Trans (2023) 51 (4): 1687–1699.
Published: 25 August 2023
... in various physiological processes and diseases, and analyze the accumulated lines of evidence supporting diverse molecular mechanisms associated with different PANX1 activation modalities. We focus on examining recent discoveries regarding PANX1 regulations by reversible post-translational modifications...
Articles
Biochem Soc Trans (2022) 50 (1): 387–401.
Published: 07 January 2022
...Jorge Ripoll-Rozada; Joshua W. C. Maxwell; Richard J. Payne; Pedro José Barbosa Pereira Tyrosine- O -sulfation is a common post-translational modification (PTM) of proteins following the cellular secretory pathway. First described in human fibrinogen, tyrosine- O -sulfation has long been associated...
Articles
Biochem Soc Trans (2021) 49 (6): 2495–2507.
Published: 02 December 2021
... minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphorylation of inflammasome...
Articles
Biochem Soc Trans (2021) 49 (6): 2891–2901.
Published: 16 November 2021
... deglycosylation glycosylation O -GlcNAc post translational modification protein engineering The O- GlcNAc modification itself is primarily governed by a pair of enzymes in mammalian cells, O- GlcNAc transferase (OGT) [ 26 ] for installation and a β- N -acetylglucosaminidase, O- GlcNAcase (OGA...
Articles
Biochem Soc Trans (2021) 49 (5): 2431–2441.
Published: 28 October 2021
... ]. This elegant solution to the challenge of packaging DNA into the nucleus is further fine-tuned post-translational modification of histone proteins (hPTMs) and modification of the DNA [ 2 , 3 ]. hPTMs are present both on the extended unstructured tail regions and in the globular domains of histone proteins...
Articles
Biochem Soc Trans (2021) 49 (2): 867–880.
Published: 26 March 2021
...Yi Zhu; Gerald W. Hart O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is actively added to and removed from thousands of intracellular proteins. As a PTM, O-GlcNAcylation tunes the functions of a protein in various ways, such as enzymatic activity...
Articles
Biochem Soc Trans (2021) 49 (2): 855–866.
Published: 11 March 2021
... molecules require essential post-translational modifications (PTMs), including hydroxylation of proline and lysine residues, and subsequent attachment of glycan moieties (galactose and glucose) to specific hydroxylysine residues on procollagen alpha chains. The resulting galactosyl-hydroxylysine (Gal-Hyl...
Articles
Biochem Soc Trans (2020) 48 (5): 1843–1858.
Published: 28 September 2020
... to disease progression. disease hydroxylation hypoxia nutrient sensing oxygenase post translational modification As 2OG-oxygenases require oxygen for catalysis, it is reasonable to suggest that their enzymatic activity may be sensitive to fluctuations in cellular oxygen levels. Moreover...
Articles
Biochem Soc Trans (2020) 48 (1): 95–101.
Published: 12 February 2020
... intermediate species. Second, our laboratory determined the ability of polyP to covalently modify proteins in a process called polyphosphorylation [ 39 ]. This new post-translational modification occurs by attachment of the polymer to a lysine residue, conferring to polyP a novel role in signal transduction...
Articles