...Michael J. Shipston BK (large conductance calcium- and voltage-activated potassium) channels are important determinants of physiological control in the nervous, endocrine and vascular systems with channel dysfunction associated with major disorders ranging from epilepsy to hypertension and obesity...

... been detected on some membrane proteins; binding of anionic lipid molecules to these hotspots can be functionally important. Binding of anionic lipids to non-annular sites on membrane proteins such as the potassium channel KcsA can also be important for function. It is argued that the packing...

... The Authors Journal compilation © 2010 Biochemical Society 2010 brain exocytosis glutamate potassium channel synaptosome Presynaptic nerve terminal and en passant varicosities are surprisingly accessible to neurochemical and bioenergetic analysis, by virtue of their ability to shear off...

...A. Dennis; L. Wang; X. Wan; E. Ficker The cardiac potassium channel hERG (human ether - a - go - go -related gene) encodes the α-subunit of the rapid delayed rectifier current I Kr in the heart, which contributes to terminal repolarization in human cardiomyocytes. Direct block of hERG/ I Kr...

... but migrates, invades, proliferates and adopts phenotypes of other cells. An intriguing aspect of modulation is switching to different ion transport systems. Initial events include loss of the Ca V 1.2 (L-type voltage-gated calcium) channel and gain of the K Ca 3.1 (IKCa) potassium channel, which putatively...

...T.M. Weiger; S. Colombatto; V. Kainz; W. Heidegger; M.A. Grillo; A. Hermann Potassium channels are ubiquitous in cells and serve essential functions in physiology and pathophysiology. Potassium channel blockers have been shown to block tumour growth by arresting cells at the G 0 /G 1 checkpoint...

... of the second transmembrane α-helix in MscL. The efficiency of hydrophobic matching between MscL and the surrounding lipid bilayer is high. Fluorescence quenching methods can also be used to study binding of lipids to non-annular sites such as those between monomers in the homotetrameric potassium channel KcsA...

... interacting with lipid phosphate groups play an important role in stabilizing the voltage-sensor domain of the KvAP channel within a bilayer. Simulations of the bacterial potassium channel KcsA reveal specific interactions of phosphatidylglycerol with an acidic lipid-binding site at the interface between...