...Charlène Martin; Mathilde Bergamelli; Cécile E. Malnou; Gisela D'Angelo For several years, a growing number of studies have highlighted the pivotal role of placental extracellular vesicles (EVs) throughout pregnancy. These membrane nanovesicles, heterogeneous in nature, composition and origin...

...Jonathan K.H. Li; Pei F. Lai; Rachel M. Tribe; Mark R. Johnson Cyclic adenosine monophosphate (cAMP) contributes to maintenance of a quiescent (relaxed) state in the myometrium (i.e. uterine smooth muscle) during pregnancy, which most commonly has been attributed to activation of protein kinase...

...Sampada Kallol; Christiane Albrecht Cholesterol is a major nutrient required for fetal growth. It is also a precursor for the synthesis of steroid hormones and essential for the development and maturation of fetal organs. During pregnancy, the placenta controls the transport of cholesterol from...

...Carmine M. Pariante Depression in pregnancy (also called ‘antenatal depression’) is being increasingly recognized as a clinically relevant condition that affects obstetric outcome, maternal behaviour and children's future mental health. The present review focuses on the molecular mechanisms...

... discuss how imprinting defects in the placenta may adversely affect the health of the fetus and its mother during pregnancy and beyond. Genomic imprinting has been explored extensively in mouse models aided by our ability to genetically manipulate gene expression. For the purpose of the present...

... normal circumstances. In developed countries, this applies mainly to micronutrients. Even now, iron deficiency is a common disorder, especially in pregnancy. Similarly, copper intake in the U.K. population is rarely above adequate levels. It is now becoming clear that nutrient deficiencies during...

... in healthy individuals ingesting diets high in saturated fat and in late pregnancy where, despite lipid-induced insulin resistance, glucose tolerance is maintained through augmented GSIS (glucose-stimulated insulin secretion). NRs (nuclear receptors) are members of a superfamily of ligand-regulated...

...V.A. Holmes; J.M.W. Wallace Pregnancy is a risk factor for venous thrombosis and the incidence of venous thromboembolism during normal pregnancy is 6-fold higher during pregnancy than in the general female population of child-bearing age. This incidence is, however, remarkably low given...

... occurs during the second half of pregnancy. In this review we will address these and other issues related to the expression of both placental and fetal leptin. 1 To whom correspondence should be addressed (e-mail [email protected] ) 13 11 2000 © 2001 Biochemical Society 2001...

... production in pancreatic islets, and the insulin secretory response to glucose is blunted in PRLR-deficient mice. These observations suggest roles for the lactogens in pancreatic development and function during pregnancy and postnatal life. GH, growth hormone GH-V, placental GH GH-N, pituitary GH PL...