... modifications for the aetiology of diseases such as spinal and bulbar muscular atrophy (Kennedy's disease) and prostate cancer, and the perspectives for pharmacological intervention. Lys residues of the R 630 KLKK 634 cluster ( Figure 1B ) are primary targets for methylation, performed by the non-histone...

... to tumourigenesis. This review considers the role of primary cilia in the pathogenesis of endocrine-related cancers. breast cancers cilia endocrine cancer ovarian cancer prostate cancer Von Hippel–Lindau Single, non-motile, primary cilia occur on the majority of mammalian cell types, but were long...

... AS of key genes and the initiation of prostate cancer metastasis. 1 Correspondence may be addressed to either author (email [email protected] or [email protected] ). 31 1 2012 The treatment of localized prostate cancer largely results in excellent survival outcome...

..., direct evidence of this has not emerged. In vivo , ps20 stimulated angiogenesis, although expression of WFDC1/ps20 was down-regulated in the reactive stroma tumour microenvironment in prostate cancer. WFDC1 expression is differential in other cancers and inflammatory conditions. Recent studies point...

... of incontinence and impotence can affect the quality of life of patients. Early intervention with localized immunotherapy represents a potential solution as lymphocyte infiltration does occur in prostate cancer lesions, and immunotherapy with dendritic cell vaccines can significantly increase survival in late...

...Emma L. Clark; Frances V. Fuller-Pace; David J. Elliott; Craig N. Robson The mechanisms involved in the transition from androgen-dependent to androgen-independent PCa (prostate cancer) remain largely undefined. The AR (androgen receptor) is an androgen-dependent transcription factor and is thought...

...N.A. Cross; M. Papageorgiou; C.L. Eaton Prostate cancers frequently metastasize to the skeleton, and it has been hypothesized that this environment selectively supports the growth of these tumours. Specifically there is strong evidence that interactions between tumour cells and BMSCs (bone marrow...

...I. Podgorski; B.E. Linebaugh; B.F. Sloane The skeleton is the most common site of metastasis in patients with advanced prostate cancer. Despite many advances in targeting skeletal metastases, the mechanisms behind the attraction of prostate cancer cells to the bone are not known. Osteoclast...

... ). 10 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 BioShuttle drug targeting molecular imaging plasmid delivery prostate cancer transfer efficiency Diagosis and treatment planning of prostate cancer is challenging because, in most cases, the tumour...

...N. Prevarskaya; M. Flourakis; G. Bidaux; S. Thebault; R. Skryma A major clinical problem with PC (prostate cancer) is the cell's ability to survive and proliferate upon androgen withdrawal. Indeed, deregulated cell differentiation and proliferation, together with the suppression of apoptosis...

... leads to disruption of male development; prostate cancer; and a neuromuscular degenerative condition termed spinal bulbar muscular atrophy or Kennedy's disease. The AR gene is X-linked and the protein is coded for by eight exons, giving rise to a C-terminal LBD (ligand-binding domain; exons 4–8), linked...

..., an endogenous cannabinoid receptor ligand) and diacylglycerols, to form LPA and PA, respectively. This AGK (acylglycerol kinase) is highly expressed in prostate cancer cell lines and the results reviewed here suggest that AGK might be a critical player in the initiation and progression of prostate cancer...

... pools, in metastatic, hormone-refractory prostate cancer (HRPC) patients. A total of 13 volunteers (mean age, 67±10 years) with metastatic HRPC were proposed for PRD and ID (0.75 g/day of oral neomycin every other week). The mean time from HRPC diagnosis to the start of the diet was 12±8 months...