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Articles

The AICD interactome: implications in neurodevelopment and neurodegeneration

Laura Lok-Haang Ng, Jessica Chow, Kwok-Fai Lau

Biochem Soc Trans (2024) 52 (6): 2539–2556.

https://doi.org/10.1042/BST20241510

Published: 13 December 2024

... with JULAC. APP intracellular domain neurodevelopment protein-protein interaction Over the last century, research in Alzheimer's disease (AD) has accumulated a large body of data corroborating the amyloid cascade hypothesis (ACH). ACH posits the extracellular deposition of amyloid-β (Aβ...

View articletitled, The AICD interactome: implications in neurodevelopment and neurodegeneration

Articles

Amyloid precursor protein and its interacting proteins in neurodevelopment

Dennis Dik-Long Chau, Laura Lok-Haang Ng, Yuqi Zhai, Kwok-Fai Lau

Biochem Soc Trans (2023) 51 (4): 1647–1659.

https://doi.org/10.1042/BST20221527

Published: 30 June 2023

... in mammals. Current knowledge, including genetic analyses of gain- and loss-of-function mutants, highlights the importance of APPs in various physiological functions. Notably, APPs consist of multiple extracellular and intracellular protein-binding regions/domains. Protein–protein interactions are crucial...

View articletitled, Amyloid precursor protein and its interacting proteins in neurodevelopment

Articles

POPDC proteins and cardiac function

Thomas Brand

Biochem Soc Trans (2019) 47 (5): 1393–1404.

https://doi.org/10.1042/BST20190249

Published: 24 September 2019

... in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed...

View articletitled, POPDC proteins and cardiac function

Articles

Co-translational control of protein complex formation: a fundamental pathway of cellular organization?

Neal K. Williams, Bernhard Dichtl

Biochem Soc Trans (2018) 46 (1): 197–206.

https://doi.org/10.1042/BST20170451

Published: 06 February 2018

[email protected] ) 13 9 2017 10 12 2017 8 1 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 co-translational interactions intrinsically disordered proteins multiprotein complexes protein–protein interaction quality control...

View articletitled, Co-translational control of protein complex formation: a fundamental pathway of cellular organization?

Articles

One Hippo and many masters: differential regulation of the Hippo pathway in cancer

David Romano, David Matallanas, Dennie T. Frederick, Keith T. Flaherty, Walter Kolch

Biochem Soc Trans (2014) 42 (4): 816–821.

https://doi.org/10.1042/BST20140030

Published: 11 August 2014

... on RAF-induced control of MST2 signalling by protein–protein interactions. Finally, we recapitulate some of the direct mechanisms, such as ubiquitin-dependent degradation or gene silencing by promoter hypermethylation, involved in MST2 pathway component down-regulation in cancers. 1...

View articletitled, One Hippo and many masters: differential regulation of the Hippo pathway in cancer

Articles

Identifying plant cell-surface receptors: combining ‘classical’ techniques with novel methods

Susanne Uebler, Thomas Dresselhaus

Biochem Soc Trans (2014) 42 (2): 395–400.

https://doi.org/10.1042/BST20130251

Published: 20 March 2014

... to determine whether TRICEPS is also suitable for large-scale LRC in plants. cross-linking ligand-based receptor-capture technology protein–protein interaction receptor-like kinase signalling peptide Cell–cell communication events play a key role during developmental processes and reproduction...

View articletitled, Identifying plant cell-surface receptors: combining ‘classical’ techniques with novel methods

Articles

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition

Christopher D.O. Cooper, Joseph A. Newman, Opher Gileadi

Biochem Soc Trans (2014) 42 (1): 130–138.

https://doi.org/10.1042/BST20130227

Published: 23 January 2014

... cellular development and differentiation [ 3 ], but when deregulated are significant mediators of tumorigenesis in various cancers [ 4 , 5 ]. Ets proteins are subclassified by the presence of further domains associated with PPIs (protein–protein interactions) or transcriptional regulation [ 2 , 3...

View articletitled, Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition

Articles

Predicting affinity- and specificity-enhancing mutations at protein–protein interfaces

Oz Sharabi, Jason Shirian, Julia M. Shifman

Biochem Soc Trans (2013) 41 (5): 1166–1169.

https://doi.org/10.1042/BST20130121

Published: 23 September 2013

...Oz Sharabi; Jason Shirian; Julia M. Shifman Manipulations of PPIs (protein–protein interactions) are important for many biological applications such as synthetic biology and drug design. Combinatorial methods have been traditionally used for such manipulations, failing, however, to explain...

View articletitled, Predicting affinity- and specificity-enhancing mutations at protein–protein interfaces

Articles

NextGen protein design

Nicholas Sawyer, Elizabeth B. Speltz, Lynne Regan

Biochem Soc Trans (2013) 41 (5): 1131–1136.

https://doi.org/10.1042/BST20130112

Published: 23 September 2013

...Nicholas Sawyer; Elizabeth B. Speltz; Lynne Regan Protein engineering is at an exciting stage because designed protein–protein interactions are being used in many applications. For instance, three designed proteins are now in clinical trials. Although there have been many successes over the last...

View articletitled, NextGen protein design

Articles

An intrinsically disordered protein, CP12: jack of all trades and master of the Calvin cycle

Brigitte Gontero, Stephen C. Maberly

Biochem Soc Trans (2012) 40 (5): 995–999.

https://doi.org/10.1042/BST20120097

Published: 19 September 2012

... 2012 Calvin cycle CP12 intrinsically disordered protein protein–protein interaction For many years, it had been thought that the ability of a protein to fulfil its cellular function depends on a well-defined three-dimensional structure. In the last decade, however, evidence has...

View articletitled, An intrinsically disordered protein, CP12: jack of all trades and master of the Calvin cycle

Articles

Solid-state nanopores for biosensing with submolecular resolution

Azadeh Bahrami, Fatma Doğan, Deanpen Japrung, Tim Albrecht

Biochem Soc Trans (2012) 40 (4): 624–628.

https://doi.org/10.1042/BST20120121

Published: 20 July 2012

... detection of single protein molecules and protein–protein interactions using synthetic nanopores Anal. Chem. 2008 80 4651 4658 39 Kowalczyk S.W. Hall A.R. Dekker C. Detection of local protein structures along DNA using solid-state nanopores Nano Lett. 2009 10 324 328 40...

View articletitled, Solid-state nanopores for biosensing with submolecular resolution

Articles

The prototypic class Ia ribonucleotide reductase from Escherichia coli : still surprising after all these years

Edward J. Brignole, Nozomi Ando, Christina M. Zimanyi, Catherine L. Drennan

Biochem Soc Trans (2012) 40 (3): 523–530.

https://doi.org/10.1042/BST20120081

Published: 22 May 2012

... equilibrium feedback regulation nucleotide biosynthesis oligomerization protein–protein interaction In all organisms, propagation of genetic material from one generation to the next requires DNA replication. The accuracy of the genetic copy and the repair of mistakes depend on balanced levels...

View articletitled, The prototypic class Ia ribonucleotide reductase from Escherichia coli : still surprising after all these years

Articles

Mammalian Hippo signalling: a kinase network regulated by protein–protein interactions

Alexander Hergovich

Biochem Soc Trans (2012) 40 (1): 124–128.

https://doi.org/10.1042/BST20110619

Published: 19 January 2012

... that functionally compensate for loss of their counterparts in Drosophila . Furthermore, studies in Drosophila and mammalian cell systems showed that Hippo signalling represents a kinase cascade that is tightly regulated by PPIs (protein–protein interactions). Several Hippo signalling molecules contain SARAH...

View articletitled, Mammalian Hippo signalling: a kinase network regulated by protein–protein interactions

Articles

Probing the druggability of protein–protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach

Noha Abdel-Rahman, Alfonso Martinez-Arias, Tom L. Blundell

Biochem Soc Trans (2011) 39 (5): 1327–1333.

https://doi.org/10.1042/BST0391327

Published: 21 September 2011

...Noha Abdel-Rahman; Alfonso Martinez-Arias; Tom L. Blundell In order to achieve greater selectivity in drug discovery, researchers in both academia and industry are targeting cell regulatory systems. This often involves targeting the protein–protein interactions of regulatory multiprotein assemblies...

View articletitled, Probing the druggability of protein–protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach

Includes: Supplementary data

Articles

The reaction mechanism of FokI excludes the possibility of targeting zinc finger nucleases to unique DNA sites

Stephen E. Halford, Lucy E. Catto, Christian Pernstich, David A. Rusling, Kelly L. Sanders

Biochem Soc Trans (2011) 39 (2): 584–588.

https://doi.org/10.1042/BST0390584

Published: 22 March 2011

..., College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K. 2 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA looping gene therapy protein–protein interaction recognition sequence restriction enzyme Type II restriction endonucleases...

View articletitled, The reaction mechanism of FokI excludes the possibility of targeting zinc finger nucleases to unique DNA sites

Articles

Protein–protein interactions in the archaeal core replisome

Stuart A. MacNeill

Biochem Soc Trans (2011) 39 (1): 163–168.

https://doi.org/10.1042/BST0390163

Published: 19 January 2011

... Biochemical Society 2011 archaeon chromosome replication DNA replication protein–protein interaction replication machinery replisome In all forms of cellular life, chromosomal DNA replication requires the complex interplay of a large number of essential and non-essential protein factors...

View articletitled, Protein–protein interactions in the archaeal core replisome

Articles

Mucolipidosis type IV and the mucolipins

Gideon Bach, David A. Zeevi, Ayala Frumkin, Aviram Kogot-Levin

Biochem Soc Trans (2010) 38 (6): 1432–1435.

https://doi.org/10.1042/BST0381432

Published: 24 November 2010

... (MLIV) mucolipin protein–protein interaction transient receptor potential mucolipin (TRPML) MLIV (mucolipidosis type IV, MIM#252650) is an LSD (lysosomal storage disorder) presenting unique features in the LSD group either in the clinical picture or the nature of the basic metabolic defect...

View articletitled, Mucolipidosis type IV and the mucolipins

Articles

Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins

Christopher Tiedje, Alexey Kotlyarov, Matthias Gaestel

Biochem Soc Trans (2010) 38 (6): 1632–1637.

https://doi.org/10.1042/BST0381632

Published: 24 November 2010

... The Authors Journal compilation © 2010 Biochemical Society 2010 mRNA stability phosphorylation protein–protein interaction translation tristetraprolin (TTP) yeast two-hybrid screen ARE AU-rich element IL interleukin IP immunoprecipitation LPS lipopolysaccharide...

View articletitled, Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins

Articles

Interactions of caeruloplasmin with other proteins participating in inflammation

Vadim B. Vasilyev

Biochem Soc Trans (2010) 38 (4): 947–951.

https://doi.org/10.1042/BST0380947

Published: 26 July 2010

...Vadim B. Vasilyev The first detailed report of a specific interaction of CP (caeruloplasmin) with another protein described its complex with LF (lactoferrin) in 2000. Since then, several protein–protein interactions involving CP have been reported, mostly concerning iron-containing proteins. The CP...

View articletitled, Interactions of caeruloplasmin with other proteins participating in inflammation

Articles

Proteomic Complex Detection using Sedimentation (ProCoDeS): screening for proteins in stable complexes and their candidate interaction partners

Marcelo P. Segura, Kathryn S. Lilley, Paul Dupree

Biochem Soc Trans (2010) 38 (4): 923–927.

https://doi.org/10.1042/BST0380923

Published: 26 July 2010

... protein–protein interaction Proteomic Complex Detection using Sedimentation (ProCoDeS) tandem affinity purification (TAP) From the perspective of method scaling, the generation of specific antibodies required for affinity purification of complexes becomes rapidly unattainable as the number...

View articletitled, Proteomic Complex Detection using Sedimentation (ProCoDeS): screening for proteins in stable complexes and their candidate interaction partners

Articles

Insight into protein–protein interactions from analytical ultracentrifugation

Stephen E. Harding, Arthur J. Rowe

Biochem Soc Trans (2010) 38 (4): 901–907.

https://doi.org/10.1042/BST0380901

Published: 26 July 2010

... large dynamic range (dissociation constants from 10 −12 M to 10 −1 M). In the present paper, we review some of the advances that have been made in the two different types of sedimentation experiment – sedimentation equilibrium and sedimentation velocity – for the analysis of protein–protein interactions...

View articletitled, Insight into protein–protein interactions from analytical ultracentrifugation

Articles

Can infrared spectroscopy provide information on protein–protein interactions?

Parvez I. Haris

Biochem Soc Trans (2010) 38 (4): 940–946.

https://doi.org/10.1042/BST0380940

Published: 26 July 2010

...Parvez I. Haris For most biophysical techniques, characterization of protein–protein interactions is challenging; this is especially true with methods that rely on a physical phenomenon that is common to both of the interacting proteins. Thus, for example, in IR spectroscopy, the carbonyl vibration...

View articletitled, Can infrared spectroscopy provide information on protein–protein interactions?

Articles

Site-specific recombination by φC31 integrase and other large serine recombinases

Margaret C.M. Smith, William R.A. Brown, Andrew R. McEwan, Paul A. Rowley

Biochem Soc Trans (2010) 38 (2): 388–394.

https://doi.org/10.1042/BST0380388

Published: 22 March 2010

..., control protein–protein interactions, which in turn determine whether recombination proceeds. The present review brings together the evidence for this model derived from the studies on φC31 integrase, Bxb1 integrase and other related proteins. 1 To whom correspondence should be addressed (email...

View articletitled, Site-specific recombination by φC31 integrase and other large serine recombinases

Articles

Evolution in protein interaction networks: co-evolution, rewiring and the role of duplication

David L. Robertson, Simon C. Lovell

Biochem Soc Trans (2009) 37 (4): 768–771.

https://doi.org/10.1042/BST0370768

Published: 22 July 2009

... interaction datasets can be used to study functional evolution directly. In terms of constraining change, the co-evolution of interacting molecules is a very subtle process. This has implications for the signal being used to predict protein–protein interactions. In terms of functional change, the ‘rewiring...

View articletitled, Evolution in protein interaction networks: co-evolution, rewiring and the role of duplication

Articles

Crystallography and protein–protein interactions: biological interfaces and crystal contacts

Bostjan Kobe, Gregor Guncar, Rebecca Buchholz, Thomas Huber, Bohumil Maco, Nathan Cowieson, Jennifer L. Martin, Mary Marfori, Jade K. Forwood

Biochem Soc Trans (2008) 36 (6): 1438–1441.

https://doi.org/10.1042/BST0361438

Published: 19 November 2008

... structural information on protein–protein complexes, and it yields the most detailed structural information about the interaction. However, there is a major issue when using MX to study protein–protein interactions: a crystal structure does not define a unique protein–protein interface. A crystal...

View articletitled, Crystallography and protein–protein interactions: biological interfaces and crystal contacts

Articles

iPEP: peptides designed and selected for interfering with protein interaction and function

Jody M. Mason, Kristian M. Müller, Katja M. Arndt

Biochem Soc Trans (2008) 36 (6): 1442–1447.

https://doi.org/10.1042/BST0361442

Published: 19 November 2008

... by hydrophobic collapse and helix formation, whereas later events account for the consolidation of more intricate intermolecular electrostatic interactions. activator protein-1 (AP-1) basic leucine zipper (bZIP) interfering peptide protein-fragment complementation assay (PCA) protein–protein interaction...

View articletitled, iPEP: peptides designed and selected for interfering with protein interaction and function

Articles

α-Helix mimetics as inhibitors of protein–protein interactions

Ishu Saraogi, Andrew D. Hamilton

Biochem Soc Trans (2008) 36 (6): 1414–1417.

https://doi.org/10.1042/BST0361414

Published: 19 November 2008

...Ishu Saraogi; Andrew D. Hamilton The inhibition of protein–protein interactions using small molecules is a viable approach for the treatment of a range of pathological conditions that result from a malfunctioning of these interactions. Our strategy for the design of such agents involves the mimicry...

View articletitled, α-Helix mimetics as inhibitors of protein–protein interactions

Articles

Kinetics and thermodynamics of metal-loaded transferrins: transferrin receptor 1 interactions

Nguyêt-Thanh Ha-Duong, Miryana Hémadi, Zohra Chikh, Jean-Michel El Hage Chahine

Biochem Soc Trans (2008) 36 (6): 1422–1426.

https://doi.org/10.1042/BST0361422

Published: 19 November 2008

...) 1 Correspondence may be addressed to either of these authors (email [email protected] or [email protected] ). 29 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 fast kinetics iron acquisition protein–protein interaction...

View articletitled, Kinetics and thermodynamics of metal-loaded transferrins: transferrin receptor 1 interactions

Articles

Development and implementation of split-GFP-based bimolecular fluorescence complementation (BiFC) assays in yeast

Emma Barnard, Neil V. McFerran, Alan Trudgett, John Nelson, David J. Timson

Biochem Soc Trans (2008) 36 (3): 479–482.

https://doi.org/10.1042/BST0360479

Published: 21 May 2008

... addition to techniques for the investigation of protein–protein interactions in this model organism. 1 To whom correspondence should be addressed (email [email protected] ). 28 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 BiFC bimolecular...

View articletitled, Development and implementation of split-GFP-based bimolecular fluorescence complementation (BiFC) assays in yeast

Articles

The effects of conformational heterogeneity on the binding of the Notch intracellular domain to effector proteins: a case of biologically tuned disorder

Angela Bertagna, Dima Toptygin, Ludwig Brand, Doug Barrick

Biochem Soc Trans (2008) 36 (2): 157–166.

https://doi.org/10.1042/BST0360157

Published: 20 March 2008

... cleavages release NICD in the receiving cell, providing access to the nucleus and complex formation with CSL (see the text for details). ADAM, a disintegrin and metalloproteinase; E(spl) , Enhancer of split . ankyrin repeat intrinsic disorder Notch signalling protein–protein interaction...

View articletitled, The effects of conformational heterogeneity on the binding of the Notch intracellular domain to effector proteins: a case of biologically tuned disorder

Articles

Control of protein translation by phosphorylation of the mRNA 5′-cap-binding complex

O.A. Pierrat, V. Mikitova, M.S. Bush, K.S. Browning, J.H. Doonan

Biochem Soc Trans (2007) 35 (6): 1634–1637.

https://doi.org/10.1042/BST0351634

Published: 23 November 2007

...–protein interaction translation regulation Gene expression can be regulated at numerous levels from alterations in the chromatin state of the gene through to transcription of DNA, processing and translation of the mRNA to post-translational modification of the protein. At the post-transcriptional...

View articletitled, Control of protein translation by phosphorylation of the mRNA 5′-cap-binding complex

Articles

A role for SUMO modification in transcriptional repression and activation

M.J. Lyst, I. Stancheva

Biochem Soc Trans (2007) 35 (6): 1389–1392.

https://doi.org/10.1042/BST0351389

Published: 23 November 2007

... histone deacetylase (HDAC) protein–protein interaction small ubiquitin-related modifier (SUMO) transcriptional activation transcriptional repression There is now substantial evidence for the involvement of SUMO modification in the regulation of gene expression [ 1 , 2 ]. From first principles...

View articletitled, A role for SUMO modification in transcriptional repression and activation

Articles

The twin-arginine transport system: moving folded proteins across membranes

F. Sargent

Biochem Soc Trans (2007) 35 (5): 835–847.

https://doi.org/10.1042/BST0350835

Published: 25 October 2007

... protein–protein interaction protein targeting twin-arginine translocase The efficient targeting of proteins to their sites of physiological function is an essential feature of all biological systems. The Tat (twin-arginine transport) system is a protein-targeting pathway found in all kingdoms...

View articletitled, The twin-arginine transport system: moving folded proteins across membranes

Articles

Rapid discovery of protein interactions by cell-free protein technologies

M. He, M.J. Taussig

Biochem Soc Trans (2007) 35 (5): 962–965.

https://doi.org/10.1042/BST0350962

Published: 25 October 2007

... protein synthesis protein in situ array protein–protein interaction protein–ribosome–mRNA complex (PRM complex) proteomic technology ribosome display Here, two cell-free protein technologies, ribosome display and PISA (protein in situ array), are described. Both technologies are discovery...

View articletitled, Rapid discovery of protein interactions by cell-free protein technologies

Articles

Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic

G.R. Budas, T. Koyanagi, E.N. Churchill, D. Mochly-Rosen

Biochem Soc Trans (2007) 35 (5): 1021–1026.

https://doi.org/10.1042/BST0351021

Published: 25 October 2007

... selective competitive inhibitor peptides and allosteric agonist peptides of individual PKC isoenzymes. The strategies and rationale used to identify these peptide regulators of protein–protein interaction may be applicable to other signalling events. Importantly, the PKC-regulating peptides proved...

View articletitled, Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic

Articles

Insights into the structure and protein–protein interactions of the pro-apoptotic protein ASPP2

S. Rotem, C. Katz, A. Friedler

Biochem Soc Trans (2007) 35 (5): 966–969.

https://doi.org/10.1042/BST0350966

Published: 25 October 2007

...S. Rotem; C. Katz; A. Friedler ASPP (apoptosis-stimulating protein of p53) 2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. Here, we provide an overview of the structure and protein–protein interactions of ASPP2. The C-terminus of ASPP2 contains Ank (ankyrin...

View articletitled, Insights into the structure and protein–protein interactions of the pro-apoptotic protein ASPP2

Articles

Visualization of protein interactions inside the secretory pathway

B. Nyfeler, H.-P. Hauri

Biochem Soc Trans (2007) 35 (5): 970–973.

https://doi.org/10.1042/BST0350970

Published: 25 October 2007

.... The underlying luminal protein–protein interactions, however, are inherently difficult to analyse, mainly due to their transient nature and the rather specialized environment of the ER. To overcome these limitations, we developed a PCA (protein fragment complementation assay) based on the citrine variant of YFP...

View articletitled, Visualization of protein interactions inside the secretory pathway

Articles

Monitoring interactions between G-protein-coupled receptors and β-arrestins

K.D.G. Pfleger, M.B. Dalrymple, J.R. Dromey, K.A. Eidne

Biochem Soc Trans (2007) 35 (4): 764–766.

https://doi.org/10.1042/BST0350764

Published: 20 July 2007

..., M.B., Lim, E.M.L., Thomas, W.G. and Eidne, K.A. Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells, pp. 1664–1670, © 2006, with permission from Elsevier. A number of studies have now utilized BRET to investigate...

View articletitled, Monitoring interactions between G-protein-coupled receptors and β-arrestins

Articles

Design and chance in the self-assembly of macromolecules

J.A.R. Worrall, M. Górna, X.Y. Pei, D.R. Spring, R.L. Nicholson, B.F. Luisi

Biochem Soc Trans (2007) 35 (3): 502–507.

https://doi.org/10.1042/BST0350502

Published: 22 May 2007

... in the structure. RhlB is similar, but contains loop extensions (L1). Based on our analysis of the protein–protein interactions between the components of the degradosome, we estimate that its cumulative mass may be in excess of 2.5 MDa [ 28 ]. In many stable complexes in the cell that are made of multiple...

View articletitled, Design and chance in the self-assembly of macromolecules

Articles

An alternative strategy for inhibiting multidrug-resistant mutants of the dimeric HIV-1 protease by targeting the subunit interface

L. Bannwarth, M. Reboud-Ravaux

Biochem Soc Trans (2007) 35 (3): 551–554.

https://doi.org/10.1042/BST0350551

Published: 22 May 2007

... against both wild-type and mutated proteases. They are therefore promising alternatives to active-site-directed inhibitors in AIDS therapy. Disruption of protein–protein interactions by small molecules is a new way to obtain potentially therapeutic molecules. 1 To whom correspondence should...

View articletitled, An alternative strategy for inhibiting multidrug-resistant mutants of the dimeric HIV-1 protease by targeting the subunit interface

Articles

The human androgen receptor AF1 transactivation domain: interactions with transcription factor IIF and molten-globule-like structural characteristics

D.N. Lavery, I.J. McEwan

Biochem Soc Trans (2006) 34 (6): 1054–1057.

https://doi.org/10.1042/BST0341054

Published: 25 October 2006

... the events of transactivation, the AR makes specific protein–protein interactions with several basal transcription factors such as TBP (TATA-box-binding protein) and TFIIF (transcription factor IIF). These interactions occur predominantly within a defined region termed AF1 (activation function-1) located...

View articletitled, The human androgen receptor AF1 transactivation domain: interactions with transcription factor IIF and molten-globule-like structural characteristics

Articles

Fluorescence lifetime imaging microscopy (FLIM) to quantify protein–protein interactions inside cells

R.R. Duncan

Biochem Soc Trans (2006) 34 (5): 679–682.

https://doi.org/10.1042/BST0340679

Published: 25 October 2006

.... Until recently, all protein interactions had to be determined in vitro using biochemical approaches: this biochemical legacy has provided cell biologists with the basis to test defined protein–protein interactions not only inside cells, but now also with high spatial resolution. These techniques can...

View articletitled, Fluorescence lifetime imaging microscopy (FLIM) to quantify protein–protein interactions inside cells

Articles

Folding and unfolding for binding: large-scale protein dynamics in protein–protein interactions

G.C.K. Roberts

Biochem Soc Trans (2006) 34 (5): 971–974.

https://doi.org/10.1042/BST0340971

Published: 25 October 2006

... The Biochemical Society 2006 folded protein guanine nucleotide dissociation inhibitor (GDI) Rho GTPase protein–protein interaction talin vinculin Figure 1 Structure of talin-(1843–1973), showing the four-helix bundle (colouring from blue at the N-terminus to red at the C-terminus) The helix...

View articletitled, Folding and unfolding for binding: large-scale protein dynamics in protein–protein interactions

Articles

DNA mimicry by proteins

D.T.F. Dryden, M.R. Tock

Biochem Soc Trans (2006) 34 (2): 317–319.

https://doi.org/10.1042/BST0340317

Published: 20 March 2006

... mimicry MfpA ocr protein–protein interaction uracil glycosylase The interactions of proteins, and particularly of enzymes, with DNA are tightly controlled spatially and temporally to ensure appropriate treatment of the genome. A classical method of control is the use of sequence-specific DNA...

View articletitled, DNA mimicry by proteins

Articles

Role of the central region of NifL in conformational switches that regulate nitrogen fixation

R. Little, I. Martinez-Argudo, R. Dixon

Biochem Soc Trans (2006) 34 (1): 162–164.

https://doi.org/10.1042/BST0340162

Published: 20 January 2006

.... 2001 26 369 376 © 2006 The Biochemical Society 2006 Azotobacter vinelandii conformational change NifL–NifA system nitrogen fixation protein–protein interaction redox regulation Expression of nif genes required for nitrogen fixation in Azotobacter vinelandii...

View articletitled, Role of the central region of NifL in conformational switches that regulate nitrogen fixation

Articles

Common principles in the biosynthesis of diverse enzymes

R.L. Jack, A. Dubini, T. Palmer, F. Sargent

Biochem Soc Trans (2005) 33 (1): 105–107.

https://doi.org/10.1042/BST0330105

Published: 01 February 2005

... have enabled us to define a chaperone-mediated ‘proofreading’ mechanism involved in co-ordinating assembly and export of twin-arginine transport-dependent enzymes. molecular chaperone [NiFe] hydrogenase protein–protein interaction Tat protein transport system N -oxide reductase twin-arginine...

View articletitled, Common principles in the biosynthesis of diverse enzymes

Articles

In vitro regulation of reporter gene transcription by the androgen receptor AF1 domain

M.A. Choudhry, I.J. McEwan

Biochem Soc Trans (2004) 32 (6): 1103–1106.

https://doi.org/10.1042/BST0321103

Published: 26 October 2004

... fusion protein. The findings from initial experiments suggest an increase in transcription initiation and elongation rates by AR-AF1–Lex. The role of protein–protein interactions involving co-activators and basal transcription factors and AR-AF1 activity are discussed. 1 To whom correspondence...

View articletitled, In vitro regulation of reporter gene transcription by the androgen receptor AF1 domain

Articles

Plant 14-3-3 protein families: evidence for isoform-specific functions?

M. R. Roberts, G. L. de Bruxelles

Biochem Soc Trans (2002) 30 (4): 373–378.

https://doi.org/10.1042/bst0300373

Published: 01 August 2002

...M. R. Roberts; G. L. de Bruxelles 14-3-3 proteins regulate a wide range of target proteins via direct protein-protein interactions. The target-binding domain in 14-3-3 proteins is highly conserved, suggesting similar biochemical properties for all 14-3-3s. However, higher eukaryotes possess...

View articletitled, Plant 14-3-3 protein families: evidence for isoform-specific functions?

Articles

Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes

Richard N. Perham, D. Dafydd Jones, Hitesh J. Chauhan, Mark J. Howard

Biochem Soc Trans (2002) 30 (2): 47–51.

https://doi.org/10.1042/bst0300047

Published: 01 April 2002

..., pyruvate decarboxylase E2p, dihydrolipoyl acetyltransferase E2o, dihydrolipoyl succinyltransferase E3, dihydrolipoyl dehydrogenase PDH, pyruvate dehydrogenase T 2 , transverse relaxation time lipoic acid lipoyl domain protein-protein interaction pyruvate dehydrogenase Metabolite...

View articletitled, Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes

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Protein interactions of fatty acid synthase II

G. Honeyman, T. Fawcett

Biochem Soc Trans (2000) 28 (6): 615–616.

https://doi.org/10.1042/bst0280615

Published: 01 December 2000

... interacted with ACP in the yeast nucleus. © 2000 Biochemical Society 2000 enoyl-ACP reductase protein-protein interaction yeast two hybrid ACP, acyl carrier protein DES, stearoyl-ACP desaturase ENR enoyl-ACP reductase FAS, fatty acid synthase TE, acyl-ACP thioesterase Fatty Acid...

View articletitled, Protein interactions of fatty acid synthase II

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