... arginine methylation cross-talk hetero-oligomeric complex PRMTs protein–protein interactions regulation Arginine methylation is a universally occurring post-translational modification (PTM) in eukaryotic organisms including mammals in which the methyl transfer occurs between the methyl donor...

... Limited on behalf of the Biochemical Society 2022 HDX-MS hydrogen exchange hydrogen-deuterium exchange mass spectrometry intrinsically disordered proteins PI4K protein–protein interactions A significant proportion of the human proteome is composed of regions that display a high degree...

...Giridhar Sekar; Adedolapo Ojoawo; Tudor Moldoveanu Apoptosis is a common cell death program that is important in human health and disease. Signaling in apoptosis is largely driven through protein–protein interactions. The BCL-2 family proteins function in protein–protein interactions as key...

...Antony J. Burton; Ghaith M. Hamza; Andrew X. Zhang; Tom W. Muir Protein–protein interactions (PPIs) in the nucleus play key roles in transcriptional regulation and ensure genomic stability. Critical to this are histone-mediated PPI networks, which are further fine-tuned through dynamic post...

... nuclear polarization membrane lipids NMR spectroscopy protein structure protein–protein interactions transmembrane proteins Cell membranes are self-assembled structures, which enclose the principal compartments of life and define the cell as its fundamental unit. Membranes primarily consist...

...Ewa Blaszczak; Natalia Lazarewicz; Aswani Sudevan; Robert Wysocki; Gwenaël Rabut Protein–protein interactions (PPIs) orchestrate nearly all biological processes. They are also considered attractive drug targets for treating many human diseases, including cancers and neurodegenerative disorders...

..., making both regions candidates as sites for protein–protein interactions and inter–lobe interface formation. We propose a sequential assembly model, whereby CESA proteins form stable trimers shortly after native folding, followed by sequential recruitment of lobes into a rosette, possibly assisted...

... drives the system towards the amyloid state. context-dependence fuzzy complexes fuzzy logic intrinsically disordered proteins protein–protein interactions Traditionally, we consider a statement either true or false (0 or 1, Boolean logic). In our everyday life, however, we use more...

... incorporated. The selective reaction shows higher cross-linking efficiency, lower background and predictable cross-linking sites. It has been applied to enhance protein/peptide stability, pinpoint protein–protein interactions, stabilize protein complexes, engineer covalent protein inhibitors, identify...

... 2020 14 4 2020 16 4 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 mass spectrometry protein–protein interactions proteome The development of new methods has paved the way for mass spectrometry (MS) to be used...

... towards identifying new UBDs which may represent the ‘dark matter’ of the ubiquitin system. © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 phosphorylation/dephosphorylation protein turnover protein–protein interactions ubiquitin signalling...

... Society 2019 allosteric regulation cellulose synthase cyclic di-GMP flagella PilZ domain protein–protein interactions C-di-GMP is a second messenger found in many environmental and pathogenic bacteria. C-di-GMP regulates a plethora of cellular functions and has attracted great attention...

... Schug ( [email protected] ) 23 6 2017 30 8 2017 4 9 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 big data analysis coevolution epistasis protein–protein interactions signaling statistical inference...

... 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 asymmetry protein complex protein–protein interactions quaternary structure stoichiometry Many if not most proteins can assemble into complexes in order to carry out their biological...

... protein–protein interactions pseudoenzyme pseudokinases signalling Counterparts of active enzymes that lack key catalytic residues and are therefore predicted to possess defective catalytic activities, termed pseudoenzymes, are thought to comprise ∼10% of proteomes throughout the kingdoms...

... function within signalling pathways. This information is vital for researchers to gain a more comprehensive knowledge of cellular networks which can then be used to develop new therapeutic strategies for disease. However, studying protein–protein interactions (PPIs) can be challenging as the interactions...

...Daniel Poglayen; Manuel Alejandro Marín-López; Jaume Bonet; Oriol Fornes; Javier Garcia-Garcia; Joan Planas-Iglesias; Joan Segura; Baldo Oliva; Narcis Fernandez-Fuentes Virtually all the biological processes that occur inside or outside cells are mediated by protein–protein interactions (PPIs...

... PO 4 3− , 137 mM NaCl, 2.7 mM KCl, pH 7.4. ‡MPD is 2-Methyl-2,4,-pentanediol. © 2015 Authors; published by Portland Press Limited 2015 affinity reagent antibody protein design protein–protein interactions protein purification repeat protein Protein design has reached...

.... Recently, a number of peptide and small molecule inhibitors of the protein-protein interaction (PPI) between Keap1 and Nrf2 have been described. These classes of compound have contrasting modes of action at the molecular level and there is emerging evidence that their biological activities have...

.... Structure 2003 11 165 174 15 Jack R.L. Buchanan G. Dubini A. Hatzixanthis K. Palmer T. Sargent F. EMBO J. 2004 23 3962 3972 15 9 2004 © 2005 The Biochemical Society 2005 molecular chaperone molybdopterin cofactor protein–protein...

... © 2004 The Biochemical Society 2004 initiation factors internal ribosomal entry site (IRES) phosphorylation poly(A)-binding protein (PABP) protein–protein interactions translation The first evidence for translational surveillance was the observation that the poly(A) tail...

... To whom correspondence should be addressed (e-mail [email protected] ). 6 7 2001 © 2001 Biochemical Society 2001 neurotransmitter transporter protein trafficking protein-protein interactions CLIP, cytoplasmic linker protein CLASP, CLIP-associated protein GABA, γ-aminobutync...