... proteins through an on–off cycle [ 6 ]. DHHC proteins are protein acyltransferases (PATs) that catalyze the addition of palmitate onto substrate proteins [ 7 , 8 ]. Conserved throughout eukaryotes, families of DHHC proteins range in size from five members in Schizosaccharomyces pombe [ 9 ] to 23...

.... Palmitoylation regulates protein membrane interactions, activity, trafficking and stability and can be constitutive or regulated by signalling inputs. A family of PATs (protein acyltransferases) is responsible for modifying proteins with palmitate or other long-chain fatty acids on the cytoplasmic face...