... Attribution License 4.0 (CC BY) . Correspondence: Jennifer C. Lee ( [email protected] ) amyloid imaging techniques phase separation protein aggregation raman spectroscopy Understanding the molecular intricacies of amyloid formation and phase separation is critical...

...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 amyloid atomic force microscopy image analysis protein aggregation protein assembly Since the development of atomic force microscopy (AFM) in the mid-1980s [ 1 ], there have been many notable advances...

...-regulated chaperones and their role in cell stress responses. 30 1 2023 12 4 2023 18 4 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 molecular chaperones oxidative stress protein aggregation proteostasis redox...

... to the accumulation of protein aggregates in the cell and disease. Sequestration of misfolded proteins into PQC compartments represents one branch of the PQC network. In neurodegenerative diseases, certain proteins form abnormal protein deposits. Which PQC compartments house misfolded proteins associated...

...Loes van Dam; Tobias B. Dansen It is well established that both an increase in reactive oxygen species (ROS: i.e. O 2 •− , H 2 O 2 and OH • ), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease. However, it is far from clear whether...

... supporting a role for kinase and GTPase activity in mediating the pathogenic effects of familial LRRK2 mutations in different model systems, with an emphasis on rodent models of PD. We also critically discuss the contribution and relevance of protein aggregation, namely of α-synuclein and tau-proteins, which...

.... Correspondence: Georgios Psakis ( [email protected] ) 13 5 2016 22 6 2016 28 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 amyloid formation apoptosis oligomerisation plants protein aggregation VDAC Refolding...

... systems that underscore the role of protein aggregation in the development of FUS-related proteinopathies. T.A.S. is funded by an European Molecular Biology Organization (EMBO) short-term fellowship [number ASTF 351/2011] and by the Russian Foundation for Basic Research [grant number 12-04-31791...

...Natalia Sanchez de Groot; Marc Torrent; Anna Villar-Piqué; Benjamin Lang; Salvador Ventura; Jörg Gsponer; M. Madan Babu Protein aggregation is being found to be associated with an increasing number of human diseases. Aggregation can lead to a loss of function (lack of active protein) or to a toxic...

... to either of these authors (email [email protected] and [email protected] ). 30 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) mitochondrion protein aggregation Saccharomyces cerevisiae...

... components of the aggresome as binding partners of MSUT-2. Thus we hypothesize that MSUT-2 plays a role in the formation and/or clearance of protein aggregates. We are currently exploring the role of MSUT-2 in tauopathy using mammalian systems. The identification of sut-2 as a gene required for tau...

... To whom correspondence should be addressed (email [email protected] ). 8 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 dementia phosphorylation protein aggregation proteolysis tau tauopathy Changes in tau conformation could be induced...

...Annakaisa Haapasalo; Jayashree Viswanathan; Lars Bertram; Hilkka Soininen; Rudolph E. Tanzi; Mikko Hiltunen Abnormal protein aggregation and intracellular or extracellular accumulation of misfolded and aggregated proteins are key events in the pathogenesis of different neurodegenerative diseases...

...Robert C. Hider; Yongmin Ma; Francisco Molina-Holgado; Alessandra Gaeta; Sourav Roy Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated...

... 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyotrophic lateral sclerosis (ALS) Cu,Zn-superoxide dismutase (SOD1) oxidative stress protein aggregation transition metal With an incidence of 1–2 per 100000 individuals per year, ALS (amyotrophic lateral...

... of cell death in several different neurodegenerative diseases could be the direct production of H 2 O 2 during the early stages of protein aggregation. In our laboratories, we have developed a sensitive ESR technique for detecting the generation of H 2 O 2 from amyloidogenic proteins [ 7...