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Keywords: protein aggregation
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Biochem Soc Trans (2024) BST20230599.
Published: 26 April 2024
... of fibrils in disease progression. Indeed, several studies are interrogating amyloid structures in ex vivo patient tissues [ 49–54 ]. As the field moves toward in cellulo studies, the complexity of the cell must be addressed, such as the role of hydration in protein aggregation. Camino et al. have...
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Biochem Soc Trans (2023) 51 (3): 1169–1177.
Published: 04 May 2023
... chaperones oxidative stress protein aggregation proteostasis redox signalling Molecular chaperones are highly conserved proteins that assist polypeptides in acquiring or retaining their native, functional conformation. Client recognition and binding are typically based on a combination...
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Biochem Soc Trans (2022) 50 (2): 759–771.
Published: 21 March 2022
... to the accumulation of protein aggregates in the cell and disease. Sequestration of misfolded proteins into PQC compartments represents one branch of the PQC network. In neurodegenerative diseases, certain proteins form abnormal protein deposits. Which PQC compartments house misfolded proteins associated...
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Biochem Soc Trans (2020) 48 (2): 379–397.
Published: 20 April 2020
...Loes van Dam; Tobias B. Dansen It is well established that both an increase in reactive oxygen species (ROS: i.e. O 2 •− , H 2 O 2 and OH • ), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease. However, it is far from clear whether...
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Biochem Soc Trans (2016) 44 (5): 1531–1540.
Published: 19 October 2016
.... Correspondence: Georgios Psakis ( g.psakis@hud.ac.uk ) 13 5 2016 22 6 2016 28 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 amyloid formation apoptosis oligomerisation plants protein aggregation VDAC In 2007...
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Biochem Soc Trans (2013) 41 (6): 1613–1617.
Published: 20 November 2013
... and deposition in insoluble inclusions contributory to the pathology? Could their presence even be sufficient to cause pathological changes typical for FUSopathies? The present review summarizes experimental data obtained in various model systems that underscore the role of protein aggregation in the development...
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Biochem Soc Trans (2012) 40 (5): 1032–1037.
Published: 19 September 2012
...Natalia Sanchez de Groot; Marc Torrent; Anna Villar-Piqué; Benjamin Lang; Salvador Ventura; Jörg Gsponer; M. Madan Babu Protein aggregation is being found to be associated with an increasing number of human diseases. Aggregation can lead to a loss of function (lack of active protein) or to a toxic...
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Biochem Soc Trans (2011) 39 (5): 1482–1487.
Published: 21 September 2011
... to either of these authors (email M.F.Tuite@kent.ac.uk and C.W.Gourlay@kent.ac.uk ). 30 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) mitochondrion protein aggregation Saccharomyces cerevisiae...
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Biochem Soc Trans (2010) 38 (4): 1016–1020.
Published: 26 July 2010
... ]. dementia phosphorylation protein aggregation proteolysis tau tauopathy Changes in tau conformation could be induced by post-translational modifications including phosphorylation and truncation [ 1 ]. Of these, tau phosphorylation has been the most actively investigated, but in the present...
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Biochem Soc Trans (2010) 38 (4): 973–976.
Published: 26 July 2010
... components of the aggresome as binding partners of MSUT-2. Thus we hypothesize that MSUT-2 plays a role in the formation and/or clearance of protein aggregates. We are currently exploring the role of MSUT-2 in tauopathy using mammalian systems. The identification of sut-2 as a gene required for tau...
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Biochem Soc Trans (2008) 36 (6): 1304–1308.
Published: 19 November 2008
...Robert C. Hider; Yongmin Ma; Francisco Molina-Holgado; Alessandra Gaeta; Sourav Roy Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated...
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Biochem Soc Trans (2008) 36 (6): 1322–1328.
Published: 19 November 2008
... dismutase (SOD1) oxidative stress protein aggregation transition metal With an incidence of 1–2 per 100000 individuals per year, ALS (amyotrophic lateral sclerosis) (OMIM #105400), also referred to as Lou Gehrig's disease, is one of the most common motor neurodegenerative disorders...
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