...Gábor Maksay; Joseph A. Marsh The assembly of proteins into complexes is fundamental to nearly all biological signalling processes. Symmetry is a dominant feature of the structures of experimentally determined protein complexes, observed in the vast majority of homomers and many heteromers. However...

... to selectively and therapeutically target GPCRs. 1 To whom correspondence should be addressed ( [email protected] ). 25 11 2015 © 2016 Authors; published by Portland Press Limited 2016 cAMP compartmentalization G protein G protein-coupled receptor (GPCR) protein complex...

... activities. COP9 signalosome (CSN) moonlighting protein pleiotropy promiscuity protein complex proteasome lid Multifunctional proteins are generally referred to as either pleiotropic proteins or proteins with moonlighting activities. The definition of a single gene product, which influences...

.... allostery dynamics oligomerization p53 protein complex quaternary structure Although Nature does not function as an engineer [ 5 ], many of its systems share an important principle with engineered networks: modularity [ 6 ]. Modularity of natural systems can be studied from different...

...A.J. Venkatakrishnan; Emmanuel D. Levy; Sarah A. Teichmann Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes...

... characterization of the proteins involved in such multimeric assemblies. Advances in MS have made possible the identification of multisubunit protein complexes isolated from cell lysates with high sensitivity and accuracy, whereas the TAP (tandem affinity purification) methodology efficiently isolates native...