... transferscence protein conformation protein kinases Kinase inhibitor resistance is frequently associated with mutations in the kinase domain [ 19 ], but can also occur through alterations elsewhere in the protein or via compensatory rewiring of signaling pathways [ 20 , 21 ]. A particularly widespread...

... [ 69 , 70 ]. A soluble fraction of this conformation can readily assemble into PHFs, suggesting that it facilitates tau aggregation [ 69 , 71 ]. aggregation oligomers post-translational modifications protein conformation recombinant protein tau Tauopathies are a heterogenous group...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cryo-electron microscopy molecular chaperones molecular mechanisms protein conformation All organisms depend on properly folded and functioning proteins...

... protein conformation protein misfolding Proteostasis refers to a delicately tuned balance between the processes of protein synthesis, folding, localization, and degradation. Proteins act as sensors, transducers, and effectors to normally maintain systemic proteostasis in the face of many...

...) 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cell adhesion extracellular matrix integrins protein conformation trafficking Metazoan...

...’ during their transport cycle. Correspondence: Alison Baker ( [email protected] ) 16 8 2018 9 10 2018 30 10 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ABC transport proteins protein conformation...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 CRIB effectors intrinsically disordered proteins protein conformation small G-proteins The field of small G-protein biology, as much as any other, has been dominated and beautifully informed...

.... This merge will allow the cross-referencing of a broad spectrum of multi-disciplinary data facilitating progress in all these fields. allosteric regulation fractals protein conformation protein dynamics Correspondence: Alexandr Kornev ( [email protected] ) 12 1 2018 14 3 2018 19...

... androgen action gene regulation protein conformation polyglutamine repeat AR, androgen receptor Hsp, heat-shock protein NTD, N-terminal domain SBMA, spinal bulbar muscular atrophy Biochemical Society Transactions (200 I), Volume 29, part 2 46 47 48 49 50 51 52 53 Sathyamoorthy, N., Gilsdotf...