... this machinery in therapeutic approaches. Correspondence: Piotr Bragoszewski ( [email protected] ) 7 10 2023 10 11 2023 14 11 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 mitochondria protein degradation...

... with exquisite specificity will be discussed. The post-translational modification of proteins by ubiquitin is involved in most cellular processes. The ubiquitin system is most well-known for its role in managing protein degradation [ 1 ], however ubiquitin transfer (ubiquitylation) has extensive non...

... associated proteostatic stresses and quality control pathways has been obtained in recent years. Six MOM associated protein degradation (MAD) pathways center on three AAA ATPases: Cdc48 in the cytoplasm, Msp1 integral to MOM, and Yme1 integral to the inner membrane. These pathways survey MOM proteome from...

... system) and autophagy. Owing to the fact that these pathways directly or indirectly regulate many cell functions, this meeting brought together an audience with a wide range of research interests, including genetic, cell biological, biochemical and structural aspects of protein degradation. Some...

... in structure and specificity between Nictaba and the SBD of the mammalian Fbs proteins, a similar role for the plant F-box proteins with a Nictaba domain in nucleocytoplasmic protein degradation in plant cells is suggested. A major proteolytic route in eukaryotes involves Ub (ubiquitin), a highly conserved...

... Biochemical Society 2008 autophagy cytosol proteasome protein degradation tripeptidyl peptidase II (TPPII) ubiquitin–proteasome system It is a well-established fact that the proteasome is the main culprit for protein turnover in the nucleus and the cytosol. The proteasome is a large...

... Society 2008 activator protein-1 (AP-1) c-Fos Fra-1 proteasome protein degradation ubiquitin The AP-1 (activator protein-1) complex is a family of dimeric transcription factors binding to DNA motifs {AP-1/TRE [PMA (‘TPA’)-responsive element]} found in many genes [ 1 ]. It is involved...

...M.G. MacKenzie; D.L. Hamilton; J.T. Murray; K. Baar Resistance-exercise training results in a progressive increase in muscle mass and force production. Following an acute bout of resistance exercise, the rate of protein synthesis increases proportionally with the increase in protein degradation...

...-translational modification protein degradation The resolution of inflammatory responses is a tightly co-ordinated active process that limits inflammation to the acute phase. It prevents prolonged inflammation, which can damage tissues and trigger diseases such as atherosclerosis, rheumatoid arthritis...

... proliferation. 29 9 2006 © 2007 The Biochemical Society 2007 antizyme antizyme inhibitor ornithine decarboxylase (ODC) polyamine protein degradation Health Implications of Dietary Amines: A joint COST Action 922 and Biochemical Society Focused Meeting held at Medico-Chirurgical...

... Meeting of the Biochemical Society, held at Imperial College, London, 16–18 December 2002 18 November 2002 Copyright 2003 Biochemical Society 2003 Crithidia fasciculata polyamine 26 S proteasome protein degradation Abbreviations used: ODC, ornithine decarboxylase...

...A. Ciechanover Until the early 1980s, protein degradation was a neglected research area, and scientists were mostly busy deciphering the genetic code and its translation to the proteome. Destruction of cellular proteins was thought to be a scavenger, non-specific and dead-end process. Although...