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Keyword: protein design
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Articles
Biochem Soc Trans (2019) 47 (5): 1233-1245.
Published: 11 October 2019
...Paul Curnow The construction of artificial membrane proteins from first principles is of fundamental interest and holds considerable promise for new biotechnologies. This review considers the potential advantages of adopting a strictly minimalist approach to the process of membrane protein design...
Articles
Biochem Soc Trans (2019) 47 (2): 701-711.
Published: 22 March 2019
... evolution evolutionary biology protein design protein engineering remote mutation Enzymes have been used as biocatalysts for thousands of years, but our ability to understand how proteins function, and to utilise this knowledge to engineer and design new proteins for our own applications is a...
Articles
Biochem Soc Trans (2016) 44 (3): 689-691.
Published: 09 June 2016
... Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . biotechnology molecular modelling protein design protein engineering synthetic biology BrisSynBio is supported by £13.6 million from Biotechnology and Biological Sciences Research Council (BBSRC...
Articles
Biochem Soc Trans (2015) 43 (5): 874-880.
Published: 09 October 2015
... important practical applications. 1 To whom correspondence should be addressed (email lynne.regan@yale.edu ) . 30 4 2015 © 2015 Authors; published by Portland Press Limited 2015 affinity reagent antibody protein design protein–protein interactions protein purification repeat...
Articles
Biochem Soc Trans (2015) 43 (5): 881-888.
Published: 09 October 2015
...Pamela J.E. Rowling; Elin M. Sivertsson; Albert Perez-Riba; Ewan R.G. Main; Laura S. Itzhaki Studying protein folding and protein design in globular proteins presents significant challenges because of the two related features, topological complexity and co-operativity. In contrast, tandem-repeat...
Articles
Biochem Soc Trans (2015) 43 (5): 819-824.
Published: 09 October 2015
... compartments. 1 These authors contributed equally to this review. 2 To whom correspondence should be addressed (email philippe.minard@u-psud.fr ) . 15 4 2015 © 2015 Authors; published by Portland Press Limited 2015 αRep combinatorial library crystal structure protein...
Articles
Biochem Soc Trans (2015) 43 (5): 856-860.
Published: 09 October 2015
...@vt.edu ) 22 4 2015 © 2015 Authors; published by Portland Press Limited 2015 alternative protein scaffold biosensor imaging agent molecular recognition protein design repeat proteins The sensitivity and specificity of biosensors and imaging agents are decidedly dependent...
Articles
Biochem Soc Trans (2015) 43 (5): 825-831.
Published: 09 October 2015
... aitziber.lopezcortajarena@imdea.org ) . 20 4 2015 © 2015 Authors; published by Portland Press Limited 2015 biomolecular templating hybrid materials protein design repeat proteins tetratricopeptide repeat nanostructures Nowadays, the industrial sector demands complicated and sophisticated...
Articles
Biochem Soc Trans (2013) 41 (5): 1166-1169.
Published: 23 September 2013
... correspondence should be addressed (email jshifman@mail.huji.ac.il ). 26 6 2013 © 2013 The Authors 2013 binding affinity binding landscape protein design protein–protein interaction saturated mutagenesis PPIs (protein–protein interactions) play a crucial role in virtually all...
Articles
Biochem Soc Trans (2013) 41 (5): 1131-1136.
Published: 23 September 2013
... decade, protein engineering still faces numerous challenges. Often, designs do not work as anticipated and they still require substantial redesign. The present review focuses on the successes, the challenges and the limitations of rational protein design today. 1 These authors contributed...
Articles
Biochem Soc Trans (2013) 41 (5): 1152-1158.
Published: 23 September 2013
... Engineering, Granta Park, Cambridge CB21 6GH, U.K. 11 6 2013 © 2013 The Authors 2013 β-roll motif engineering biomaterial protein design repeat protein tetratricopeptide repeat Repeat or solenoid proteins are incredibly ubiquitous protein folds that typically form non-globular...
Articles
Biochem Soc Trans (2012) 40 (3): 561-566.
Published: 22 May 2012
... oxidoreductase protein design protein engineering synthetic protein All too commonly, it is inferred that a specific biochemical function is necessarily linked with either a singular enzyme structure or a particular primary sequence. This ignores the apparent ‘memory-less’ random Markovian process of...
Articles
Biochem Soc Trans (2007) 35 (3): 487-491.
Published: 22 May 2007
... coiled coil leucine-zipper nanostructured material peptide α-helix protein design self-assembling peptide Hierarchical self-assembly is a prerequisite for the organization of biological systems [ 1 ]. It is particularly strongly emphasized in biopolymer architectures that underpin complex...