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Keywords: protein dynamics
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Biochem Soc Trans (2021) 49 (1): 131–144.
Published: 24 December 2020
... of amphipathic helices. This tool has shown success in cryo-EM, solution state NMR [ 25 ] and MAS ssNMR [ 13 , 26 ]. enzyme structure enzyme-substrate interactions isotope labelling magic angle spinning molecular docking protein dynamics Enzyme catalysis is required for the vast majority...
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Biochem Soc Trans (2019) 47 (4): 1101–1116.
Published: 08 August 2019
... of the Biochemical Society 2019 molecular conformations protein dynamics protein-tyrosine kinases regulatory mechanisms At the end of the 1800s, photographers had been producing still images for nearly a century. The advent of moving pictures at this time caused a dramatic shift in the viewer's...
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Biochem Soc Trans (2018) 46 (3): 587–597.
Published: 20 April 2018
... allosteric regulation fractals protein conformation protein dynamics Allostery is a process that regulates the activity of enzymes via binding a modulator at a distal site, sterically different from the chemically active site. It is now well recognized that allostery is a fundamental property...
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Biochem Soc Trans (2016) 44 (3): 905–915.
Published: 09 June 2016
... of the Biochemical Society 2016 ABC proteins EPR spectroscopy membrane transport protein dynamics spin labelling Membrane transporter proteins comprise a wide variety of proteins which underpin a diverse range of functions–from the import of vital solutes to the efflux of a multitude of drugs...
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Biochem Soc Trans (2015) 43 (5): 773–786.
Published: 09 October 2015
...-translational modifications. A powerful tool to study the regulation of membrane signalling enzymes and complexes is hydrogen deuterium exchange–MS (HDX–MS), a technique that allows for the interrogation of protein dynamics upon membrane binding and recruitment. This review will highlight the theory...
Articles
Biochem Soc Trans (2014) 42 (1): 145–150.
Published: 23 January 2014
...Kristina Lorenzen; Tony Pawson In recent years, HDX-MS (hydrogen–deuterium exchange coupled to MS) on biomolecules has evolved from a niche technique to a powerful method in the investigation of protein dynamics. Protein kinases, in particular, represent an area of active study using this technique...
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Biochem Soc Trans (2014) 42 (1): 139–144.
Published: 23 January 2014
... of York, U.K., 17–19 June 2013. Organized and Edited by Nicholas Brindle (University of Leicester, U.K.), Sandip Patel (University College London, U.K.) and Stephen Yarwood (University of Glasgow, U.K.) allostery cAMP cGMP covariance NMR protein dynamics singular value decomposition (SVD...
Articles
Biochem Soc Trans (2012) 40 (5): 955–962.
Published: 19 September 2012
... compilation © 2012 Biochemical Society 2012 intrinsically disordered protein integrative method nuclear magnetic resonance (NMR) protein dynamics small-angle X-ray scattering (SAXS) IDPs (intrinsically disordered proteins) are nowadays recognized as fundamental elements to explain...
Articles
Biochem Soc Trans (2012) 40 (3): 531–538.
Published: 22 May 2012
... applications, these investigations provide fundamental insights into protein dynamics. Upon photon absorption, the free p -HBI chromophore undergoes strong twisting around the methylene bridge linking its two cyclic moieties, potentially leading to cis – trans isomerization and accounting for the lack...
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Biochem Soc Trans (2012) 40 (3): 515–521.
Published: 22 May 2012
...David R. Glowacki; Jeremy N. Harvey; Adrian J. Mulholland One of the most controversial questions in enzymology today is whether protein dynamics are significant in enzyme catalysis. A particular issue in these debates is the unusual temperature-dependence of some kinetic isotope effects for enzyme...
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Biochem Soc Trans (2012) 40 (2): 409–414.
Published: 21 March 2012
... are located at opposite sites of the β-sandwich. The ‘BC’ (L2) and ‘FG’ loops (L5) of C2 bind Ca 2+ , while the AB, CD and EF loops bind Ca 2+ in Calx-β domains. calcium binding Calx-β magnesium binding protein dynamics protein stability sodium/calcium exchanger (NCX) The NCX (Na + /Ca 2...
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Biochem Soc Trans (2012) 40 (1): 219–223.
Published: 19 January 2012
... Society 2012 allostery cAMP cGMP chemical shift covariance analysis (CHESCA) exchange protein directly activated by cAMP (Epac) nuclear magnetic resonance (NMR) protein dynamics cAMP is an ancient second messenger that controls a multitude of essential cellular processes by binding...
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Biochem Soc Trans (2009) 37 (2): 349–353.
Published: 20 March 2009
... and substrate in a reactive configuration from which hydride is transferred by quantum mechanical tunnelling. In the present paper, we review results from experiments that probe the influence of protein dynamics on the chemical step of the reaction catalysed by TmDHFR (DHFR from Thermotoga maritima...
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Biochem Soc Trans (2006) 34 (5): 979–982.
Published: 25 October 2006
... of the Cy3 and Cy5 emission until one component is irreversibly photobleached ( Figure 2 and [ 16 ]). If this FRET pair is used to explore protein dynamics on the same time scale as blinking, then careful control experiments are required to establish the behaviour of the protein rather than...
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