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Keyword: protein kinase A (PKA)
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Articles
Biochem Soc Trans (2014) 42 (2): 265-269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling Mitochondria are marvels of compartmentalization, and this property is intimately connected with their function. Compartmentalization of these organelles is achieved thanks to two structures with...
Articles
Biochem Soc Trans (2014) 42 (2): 302-307.
Published: 20 March 2014
...) hyperpolarization-activated cyclic-nucleotide-modulated channel (HCN) protein kinase A (PKA) selectivity signalling cAMP is a universal second messenger that relays and amplifies extracellular signals by causing conformational changes in intracellular CBDs (cAMP-binding domains) [ 1 , 2 ]. In eukaryotes...
Articles
Biochem Soc Trans (2014) 42 (2): 279-283.
Published: 20 March 2014
... light chain phosphatase (MLCP) platelet protein kinase A (PKA) RhoA Rho-associated kinase (ROCK) Circulating blood platelets scan the integrity of the vascular endothelium for damage and adhere to areas of injury where the extracellular matrix proteins collagen and vWF (von Willebrand factor...
Articles
Biochem Soc Trans (2014) 42 (2): 289-294.
Published: 20 March 2014
... whom correspondence should be addressed (email khalid.naseem@hyms.ac.uk ). 19 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 A-kinase-anchoring protein (AKAP) cAMP compartmentalization phosphodiesterase (PDE) platelet protein kinase A (PKA...
Articles
Biochem Soc Trans (2014) 42 (1): 89-97.
Published: 23 January 2014
... endothelial barrier function exchange protein directly activated by cAMP (Epac) guanine-nucleotide-exchange factor (GEF) protein kinase A (PKA) vascular smooth muscle vasculature vasodilatation The second messenger cAMP controls a range of vascular processes, including endothelial barrier...
Articles
Biochem Soc Trans (2013) 41 (4): 981-986.
Published: 18 July 2013
... that are independent of catalysis. 1 To whom correspondence should be addressed (email staylor@ucsd.edu ). 20 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 ATP GTP protein kinase protein kinase A (PKA) pseudokinase Raf Protein...
Articles
Biochem Soc Trans (2013) 41 (4): 1083-1088.
Published: 18 July 2013
... growth factor receptor (EGFR) kinase kinase inhibitor protein kinase A (PKA) pseudokinase The eukaryotic cell is a staggeringly complex environment, with intricate regulatory mechanisms underpinning every aspect of its behaviour. At the heart of many of these regulatory mechanisms is the...
Articles
Biochem Soc Trans (2012) 40 (1): 51-57.
Published: 19 January 2012
... © 2012 Biochemical Society 2012 cAMP exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor guanine-nucleotide-exchange factor heart failure protein kinase A (PKA) cAMP is a universal second messenger which is produced from ATP by adenylate cyclase upon...
Articles
Biochem Soc Trans (2012) 40 (1): 210-214.
Published: 19 January 2012
... 2012 cardioprotection heat-shock protein 20 (Hsp20) phosphodiesterase type 4 (PDE4) phosphorylation protein kinase A (PKA) small heat-shock protein Hsps (heat-shock proteins) are a diverse group of molecular chaperones that are up-regulated in response to cellular stress. Originally...
Articles
Biochem Soc Trans (2011) 39 (2): 487-491.
Published: 22 March 2011
... it depends on the presence of MAF1. 1 email Annemieke.Michels@unil.ch 8 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 MAF1 mammalian target of rapamycin complex 1 (mTORC1) protein kinase A (PKA) RNA polymerase III S6 kinase 1 (S6K1) Sch9...
Articles
Biochem Soc Trans (2007) 35 (5): 931-937.
Published: 25 October 2007
... protein (AKAP) cAMP compartmentalization extracellular-signal-regulated kinase (ERK) phosphodiesterase (PDE) protein kinase A (PKA) cAMP activates Epac (exchange protein directly activated by cAMP) [ 1 ], cAMP-regulated ion channels [ 2 ] and, last but not least, the broad-substrate...
Articles
Biochem Soc Trans (2007) 35 (5): 938-941.
Published: 25 October 2007
...-arrestin cAMP phosphodiesterase cardiomyocyte phosphodiesterase-4D5 (PDE4D5) protein kinase A (PKA) cAMP is a critical second messenger that can influence and regulate a vast array of cellular events vital for the response and control of signalling pathways to environmental cues [ 1 – 3 ]. It...
Articles
Biochem Soc Trans (2006) 34 (6): 1299-1302.
Published: 25 October 2006
... localized transmitter-mediated modulation of sodium channels by other protein kinases. 1 To whom correspondence should be addressed (email Scheuer@u.washington.edu ). 26 6 2006 © 2006 The Biochemical Society 2006 action potential depolarization phosphorylation protein kinase A...
Articles
Biochem Soc Trans (2006) 34 (4): 465-467.
Published: 21 July 2006
... compartmentalization protein kinase A (PKA) Although the investigation of cAMP signalling has been underway for over 50 years, it was not until the early 1980s that the compartmentalized modulation of these events was appreciated. This concept developed from physiological experiments showing that stimulation of...
Articles
Biochem Soc Trans (2006) 34 (4): 476-479.
Published: 21 July 2006
...) immunomodulation Lck phosphodiesterase protein kinase A (PKA) T-cell TCR (T-cell receptor) is a multimeric complex consisting of two functional units, one involved in ligand binding (αβ) and the other in signal transduction (CD3 γ, δ, ϵ and ζ chains). One of the most immediate events taking place in T...
Articles
Biochem Soc Trans (2006) 34 (4): 510-511.
Published: 21 July 2006
... cAMP cardiomyocyte phosphodiesterase (PDE) protein kinase A (PKA) The force and frequency of cardiomyocyte contraction is continuously tuned by a number of signals conveyed from the bloodstream, the neighbouring cells and the cardiac nerve endings. Many such signals exert their function...
Articles
Biochem Soc Trans (2006) 34 (4): 489-491.
Published: 21 July 2006
...@biotek.uio.no ). 28 3 2006 © 2006 The Biochemical Society 2006 A-kinase-anchoring protein (AKAP) cAMP excitation–contraction coupling heart phospholamban (PLB) protein kinase A (PKA) sarcoplasmic/endoplasmic-reticulum Ca 2+ -ATPase 2 (SERCA2) Contraction and relaxation of heart...
Articles
Biochem Soc Trans (2006) 34 (4): 472-473.
Published: 21 July 2006
... kinase A (PKA) scaffolding protein A variety of hormones, neurotransmitters and other stimuli mediate activation of the G s /adenylate cyclase system and thereby induce the generation of the second messenger cAMP and activation of PKA (protein kinase A), a serine/threonine kinase. The inactive PKA...
Articles
Biochem Soc Trans (2006) 34 (4): 498-501.
Published: 21 July 2006
.... 1 To whom correspondence should be addressed (email anders.tengholm@mcb.uu.se ). 28 3 2006 © 2006 The Biochemical Society 2006 calcium cAMP fluorescein arsenical helix binder (FlAsH) glucagon-like peptide-1 insulin protein kinase A (PKA) Spatial compartmentalization...
Articles
Biochem Soc Trans (2005) 33 (6): 1354-1356.
Published: 26 October 2005
... 2005 © 2005 The Biochemical Society 2005 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) calcium/calmodulin-dependent protein kinase (CaMKII) long-term potentiation (LTP) phosphorylation protein kinase A (PKA) synaptic plasticity A major component...
Articles
Biochem Soc Trans (2005) 33 (6): 1327-1329.
Published: 26 October 2005
...-associated protein (MAP) protein kinase A (PKA) Rap1 Many extracellular physiological signalling agents increase the intracellular levels of the ubiquitous second messenger cAMP [ 1 ]. These include immunomodulators, neurotransmitters and hormones, which typically activate the seven-transmembrane...
Articles
Biochem Soc Trans (2005) 33 (6): 1330-1332.
Published: 26 October 2005
... Alzheimer's disease cAMP exchange protein directly activated by cAMP (EPAC) guanine nucleotide-exchange factor (GEF) protein kinase A (PKA) Rap Although the effects of cAMP-mediated signalling are wide ranging, there are only two general cAMP effectors, i.e. proteins that are activated by binding...
Articles
Biochem Soc Trans (2005) 33 (6): 1316-1318.
Published: 26 October 2005
... exocytosis protein kinase A (PKA) Various hormones and other signals induce the generation of cAMP by activation of adenylate cyclase, most often via G-protein-coupled receptors. The most important effector molecule of cAMP is PKA (protein kinase A), a serine/threonine kinase that is involved in...
Articles
Biochem Soc Trans (2005) 33 (1): 257-260.
Published: 01 February 2005
... © 2005 The Biochemical Society 2005 adenylate cyclase cAMP fbp1 transcription G-protein Schizosaccharomyces pombe protein kinase A (PKA) Nutrient sensing is critical to the survival of both prokaryotic and eukaryotic micro-organisms, which adjust their metabolism to utilize the...
Articles
Biochem Soc Trans (2004) 32 (3): 443-446.
Published: 01 June 2004
... Chancellors Conference Centre, University of Manchester, 1–3 December 2003 19 November 2003 © 2004 Biochemical Society 2004 integrin mitogen-activated protein kinase (MAP kinase) motility p21-activated kinase (PAK) protein kinase A (PKA) Rho GTPase Abbreviations used: ECM...