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Keywords: protein kinase A (PKA)
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Articles
Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling Historically, mitochondria were recognized solely as the ‘powerhouses’ of the cell, responsible for the generation of nearly 90% of cellular ATP. However, this view has changed drastically, and now...
Articles
Biochem Soc Trans (2014) 42 (2): 289–294.
Published: 20 March 2014
... Biochemical Society 2014 A-kinase-anchoring protein (AKAP) cAMP compartmentalization phosphodiesterase (PDE) platelet protein kinase A (PKA) Unravelling these issues will improve our understanding of how the cAMP signalling pathway controls platelets in health and disease. Targeting...
Articles
Biochem Soc Trans (2014) 42 (2): 279–283.
Published: 20 March 2014
... the mechanisms by which cAMP signalling maintains MLCP in an active state to control platelet contractile machinery. cAMP myosin light chain phosphatase (MLCP) platelet protein kinase A (PKA) RhoA Rho-associated kinase (ROCK) Circulating blood platelets scan the integrity of the vascular...
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Articles
Biochem Soc Trans (2014) 42 (1): 89–97.
Published: 23 January 2014
... endothelial barrier function exchange protein directly activated by cAMP (Epac) guanine-nucleotide-exchange factor (GEF) protein kinase A (PKA) vascular smooth muscle vasculature vasodilatation The second messenger cAMP controls a range of vascular processes, including endothelial barrier...
Articles
Biochem Soc Trans (2013) 41 (4): 981–986.
Published: 18 July 2013
... that are independent of catalysis. 1 To whom correspondence should be addressed (email [email protected] ). 20 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 ATP GTP protein kinase protein kinase A (PKA) pseudokinase Raf Protein kinases represent one...
Articles
Biochem Soc Trans (2013) 41 (4): 1083–1088.
Published: 18 July 2013
... growth factor receptor (EGFR) kinase kinase inhibitor protein kinase A (PKA) pseudokinase Oncogenic kinases present significant drug targets for directed chemotherapy [ 7 ]. Small-molecule inhibitors that prevent oncogenic kinases from binding ATP (and subsequently performing phosphotransfer...
Articles
Biochem Soc Trans (2012) 40 (1): 51–57.
Published: 19 January 2012
... failure protein kinase A (PKA) cAMP is a universal second messenger which is produced from ATP by adenylate cyclase upon activation of G s PCRs (G s -protein-coupled receptors) [ 1 ]. Pivotal in shaping and controlling intracellular cAMP gradients are PDEs (phosphodiesterases) [ 2 ]. cAMP is one...
Articles
Biochem Soc Trans (2012) 40 (1): 210–214.
Published: 19 January 2012
... (PDE4) phosphorylation protein kinase A (PKA) small heat-shock protein Hsps (heat-shock proteins) are a diverse group of molecular chaperones that are up-regulated in response to cellular stress. Originally described in Drosophila melanogaster as a group of proteins whose expression...
Articles
Biochem Soc Trans (2011) 39 (2): 487–491.
Published: 22 March 2011
..., as it depends on the presence of MAF1. 1 email [email protected] 8 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 MAF1 mammalian target of rapamycin complex 1 (mTORC1) protein kinase A (PKA) RNA polymerase III S6 kinase 1 (S6K1) Sch9...
Articles
Biochem Soc Trans (2007) 35 (5): 931–937.
Published: 25 October 2007
... 2007 A-kinase-anchoring protein (AKAP) cAMP compartmentalization extracellular-signal-regulated kinase (ERK) phosphodiesterase (PDE) protein kinase A (PKA) cAMP activates Epac (exchange protein directly activated by cAMP) [ 1 ], cAMP-regulated ion channels [ 2 ] and, last...
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Articles
Biochem Soc Trans (2006) 34 (6): 1299–1302.
Published: 25 October 2006
... of the striatum [ 15 ]. action potential depolarization phosphorylation protein kinase A (PKA) sodium channel tyrosine kinase It is becoming increasingly evident that protein kinases frequently form signalling complexes with their substrates [ 20 ]. Consistent with this idea, PKA co-purifies...
Articles
Biochem Soc Trans (2006) 34 (4): 465–467.
Published: 21 July 2006
... compartmentalization protein kinase A (PKA) Although the investigation of cAMP signalling has been underway for over 50 years, it was not until the early 1980s that the compartmentalized modulation of these events was appreciated. This concept developed from physiological experiments showing that stimulation...
Articles
Biochem Soc Trans (2006) 34 (4): 510–511.
Published: 21 July 2006
... cAMP cardiomyocyte phosphodiesterase (PDE) protein kinase A (PKA) The force and frequency of cardiomyocyte contraction is continuously tuned by a number of signals conveyed from the bloodstream, the neighbouring cells and the cardiac nerve endings. Many such signals exert their function...
Articles
Biochem Soc Trans (2006) 34 (4): 472–473.
Published: 21 July 2006
... kinase A (PKA) scaffolding protein A variety of hormones, neurotransmitters and other stimuli mediate activation of the G s /adenylate cyclase system and thereby induce the generation of the second messenger cAMP and activation of PKA (protein kinase A), a serine/threonine kinase. The inactive PKA...
Articles
Biochem Soc Trans (2006) 34 (4): 476–479.
Published: 21 July 2006
... Lck phosphodiesterase protein kinase A (PKA) T-cell Interestingly, the cAMP inhibitory pathway has also been shown to be implicated in several immune diseases [ 41 – 47 ]. T-cells from HIV-infected patients have elevated levels of cAMP and hyperactivation of PKA. Targeting of the cAMP–PKA...
Articles
Biochem Soc Trans (2006) 34 (4): 498–501.
Published: 21 July 2006
... To whom correspondence should be addressed (email [email protected] ). 28 3 2006 © 2006 The Biochemical Society 2006 calcium cAMP fluorescein arsenical helix binder (FlAsH) glucagon-like peptide-1 insulin protein kinase A (PKA) Spatial compartmentalization...
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Biochem Soc Trans (2006) 34 (4): 489–491.
Published: 21 July 2006
... 878 A-kinase-anchoring protein (AKAP) cAMP excitation–contraction coupling heart phospholamban (PLB) protein kinase A (PKA) sarcoplasmic/endoplasmic-reticulum Ca 2+ -ATPase 2 (SERCA2) Contraction and relaxation of heart muscle cells are regulated by calcium (Ca 2+ ) cycling...
Articles
Biochem Soc Trans (2005) 33 (6): 1327–1329.
Published: 26 October 2005
... (MAP) protein kinase A (PKA) Rap1 Many extracellular physiological signalling agents increase the intracellular levels of the ubiquitous second messenger cAMP [ 1 ]. These include immunomodulators, neurotransmitters and hormones, which typically activate the seven-transmembrane domain class...
Articles
Biochem Soc Trans (2005) 33 (6): 1330–1332.
Published: 26 October 2005
... Alzheimer's disease cAMP exchange protein directly activated by cAMP (EPAC) guanine nucleotide-exchange factor (GEF) protein kinase A (PKA) Rap Although the effects of cAMP-mediated signalling are wide ranging, there are only two general cAMP effectors, i.e. proteins that are activated by binding...
Articles
Biochem Soc Trans (2005) 33 (6): 1316–1318.
Published: 26 October 2005
... of anchored PKA signalling (e.g. renal and cardiovascular diseases). © 2005 The Biochemical Society 2005 A-kinase anchoring protein (AKAP) aquaporin-2 (AQP2) cAMP compartmentalization exocytosis protein kinase A (PKA) Various hormones and other signals induce the generation of cAMP...
Articles
Biochem Soc Trans (2005) 33 (6): 1354–1356.
Published: 26 October 2005
... © 2005 The Biochemical Society 2005 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) calcium/calmodulin-dependent protein kinase (CaMKII) long-term potentiation (LTP) phosphorylation protein kinase A (PKA) synaptic plasticity AMPA α-amino-3-hydroxy...
Articles
Biochem Soc Trans (2005) 33 (1): 257–260.
Published: 01 February 2005
... The Biochemical Society 2005 adenylate cyclase cAMP fbp1 transcription G-protein Schizosaccharomyces pombe protein kinase A (PKA) Nutrient sensing is critical to the survival of both prokaryotic and eukaryotic micro-organisms, which adjust their metabolism to utilize the resources available...
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Biochem Soc Trans (2004) 32 (3): 443–446.
Published: 01 June 2004
... at Chancellors Conference Centre, University of Manchester, 1–3 December 2003 19 November 2003 © 2004 Biochemical Society 2004 integrin mitogen-activated protein kinase (MAP kinase) motility p21-activated kinase (PAK) protein kinase A (PKA) Rho GTPase Abbreviations used: ECM...