...-lymphocyte glycolysis hypoxia-inducible factor 1α (HIF1α) mammalian target of rapamycin complex 1 (mTORC1) protein kinase B (PKB) trafficking mTOR (mammalian target of rapamycin) is a serine/threonine kinase with important functions for a range of cellular processes. mTOR forms two distinct...

... kinase B (PKB) protein turnover The machinery of the body, i.e. muscle, tendon, ligament and bone, accounts for the overwhelming amount of protein-bound amino acid in the body, with the collagen in connective tissue alone accounting for approx. 3 kg of body weight. We now have a much better idea...

... ). 1 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 protein kinase B (PKB) protein kinase C (PKC) phosphoinositide-dependent kinase 1 (PDK1) phosphorylation pleckstrin homology domain (PH domain) protein serine/threonine kinase In mammals, cellular...

...) phosphorylation protein kinase B (PKB) Class I PI3Ks (phosphoinositide 3-kinases) generate PIP 3 (phosphatidylinositol 3,4,5-trisphosphate), which interacts with specialized lipid-binding domains present in protein kinases [such as Akt/PKB (protein kinase B)], regulators of small GTPases and scaffolding...

... brian.hemmings@fmi.ch ). 16 12 2006 © 2007 The Biochemical Society 2007 adipocyte differentiation cancer glucose homoeostasis mouse model phosphatase and tensin homologue deleted on chromosome 10 (PTEN) protein kinase B (PKB) The serine/threonine kinase PKB (protein kinase B, also...

..., and place specific emphasis on the role of these pathways in insulin-stimulated glucose uptake. 1 To whom correspondence should be addressed (email j.tavare@bristol.ac.uk ). 21 11 2005 © 2006 The Biochemical Society 2006 AS160 glucose homoeostasis GTPase insulin protein kinase...

... (PI3K) protein kinase B (PKB) signal transduction Vav Stimulation of the BCR (B-cell antigen receptor) results in the activation of protein tyrosine kinases and the recruitment of scaffold proteins leading to the assembly of a multiprotein complex, termed a signalsome. This complex regulates...