.... Phosphorylation, a reversible post-translational protein modification regulating important cellular functions, is mediated by complementary enzymes, protein kinases and phosphatases. Protein phosphatases can be grouped into two major categories according to the residues they dephosphorylate. Protein tyrosine...

...Iris Verbinnen; Pieter Vaneynde; Sara Reynhout; Lisa Lenaerts; Rita Derua; Gunnar Houge; Veerle Janssens By removing Ser/Thr-specific phosphorylations in a multitude of protein substrates in diverse tissues, Protein Phosphatase type 2A (PP2A) enzymes play essential regulatory roles in cellular...

... with p-sites in disordered regions. The latter makes these amino acid sequences crossroads for signaling and motif strength between kinases, pSer/pThr-binding proteins and phosphatases. 14-3-3 proteins intrinsically disordered proteins protein phosphatases protein-serine-threonine kinases...

... of the system are protein phosphatases and the regulation of their activity in space and time. As the NE is clearly becoming an interesting compartment for the control and transduction of several signalling pathways, in this review we will focus on the role of Protein Phosphatases at the NE since...

... contributes to aging. Conversely, studies using genetically tractable model organisms argue that adaptation to environmental stress or resistance to proteotoxicity can extend lifespan [ 7 ]. neurodegeneration protein phosphatases therapeutics translation factors unfolded protein response ©...

... protein phosphatases PTP4A3 The phosphatase of regenerating liver (PRL)-3 protein belongs to the PRL subfamily, which are dual-specificity phosphatases classified as a subgroup of protein tyrosine phosphatases (PTP). This subfamily of small proteins (∼22 kDa) includes three members, PRL-1, -2...