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Keywords: protein structure
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1907–1919.
Published: 18 September 2023
... protein structure redox chemistry Cytoglobin (Cygb) is the fourth member of the globin family found in humans after erythrocyte haemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb). Discovered in 2001 and initially named stellate cell activating protein (STAP) [ 1 ] and histoglobin [ 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1257–1269.
Published: 24 May 2023
... transcription protein structure Sen1 Transcription in animal/fungal cells is performed by three RNA polymerases, with RNA Pol II dealing with mRNAs and some non-coding RNAs (ncRNAs) [ 1 , 2 ]. RNA polymerases employ different termination pathways [ 3–5 ]. In the case of RNA Pol II transcription...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 855–869.
Published: 21 April 2023
... into structural differences among caveolin family members that enable them to support the proper functions of diverse tissues and organisms. caveolae caveolins cell membranes cryo-electron microscopy membrane proteins protein structure Correspondence: Anne K. Kenworthy ( [email protected]...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 183–193.
Published: 20 January 2023
... , deletion of the CI operon and the ndh gene resulted in a decrease in virulence that was even more pronounced than deletion of the ndh gene alone [ 25 ]. cryo-electron microscopy electron transport chain membrane proteins Mycobacterium tuberculosis protein structure Bacteria...
Articles
Shramana Chatterjee, Santhosh Gatreddi, Swati Gupta, Jorge L. Nevarez, Joel A. Rankin, Aiko Turmo, Jian Hu, Robert P. Hausinger
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (4): 1187–1196.
Published: 12 August 2022
... portion of the protein structure being solved due to apparent proteolysis ( Figure 4A ) [ 38 ]. This domain includes a novel CTP-binding pocket involving residues from three separate chains of the protein ( Figure 4B ). The N-terminal domain of unknown structure has a histidine-rich region, thought...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 747–758.
Published: 14 March 2022
... computational biology drug discovery and design molecular docking platforms protein structure Drug repurposing possesses great advantages in terms of establishing new therapeutic options for specific disorders by exploiting drugs used for other conditions that are already known to be largely safe...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 541–554.
Published: 07 February 2022
... protein conformations, models to calculate experimental observables from protein structure, and methods to refine ensembles against experimental data. We also provide examples of recent applications of integrative conformational ensemble determination to study IDPs and multidomain proteins and suggest...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bacteriophages cryo-electron microscopy protein structure structural biology virology Bacteriophages, or phages, infect prokaryotes and are the most abundant biological entity on the planet [ 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1505–1513.
Published: 16 August 2021
... and membrane protein studies, which uniquely provides information on structure, interactions and dynamics of membrane proteins. High resolution approaches are discussed in conjunction with applications of NMR methods to studies of membrane lipid and protein structure and interactions. Signal enhancement...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 965–976.
Published: 05 March 2021
... protein structure proteolysis Asparaginyl endopeptidases (AEPs) are cysteine proteases of the C13 family (clan CD) that cleave at the carboxyl-terminal side of Asx (Asp or Asn). First discovered in legume plants [ 1 ], these enzymes were thus categorised as legumains (EC 3.4.22.34) [ 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2457–2466.
Published: 18 December 2020
... (CC BY) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. ion mobility mass spectrometry protein structure...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2615–2624.
Published: 10 November 2020
... pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. protein structure ring ligases TRIM proteins ubiquitin ligases An abundance of cellular functions is controlled by the attachment of a 76-residue ubiquitin (Ub) molecule to a protein...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 1227–1241.
Published: 05 May 2020
... by the participation of University of Groningen in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. membrane proteins protein structure transport Structural studies of membrane transporters from diverse protein families have revealed that alternating access...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 37–45.
Published: 15 January 2019
... BY-NC-ND) . AAA proteins cryo-electron microscopy endosomal sorting protein disassembly protein structure E ndosomal S orting C omplex R equired for T ransport (ESCRT) pathways drive membrane fission in numerous cellular processes, including cytokinesis, multivesicular...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 433–440.
Published: 21 December 2018
... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . function membrane lipid oligomerisation protein structure transporter Integral membrane transporters play key roles in the effective movement of specific molecules...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 157–167.
Published: 17 December 2018
... ( [email protected] ) 28 9 2018 1 11 2018 6 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 acyl coenzyme A palmitoylation protein lipidation protein structure S-acylation transmembrane proteins Of all...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 47–61.
Published: 17 December 2018
... transmission at millisecond time scale. Representative structures of this group, solved by cryo-EM and X-ray crystallography, combined electrophysiology and computational methods such MD have been powerful tools to the structure–function elucidation of these proteins. Structurally, these channels...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1093–1098.
Published: 28 August 2018
... transmembrane conductance regulator ion channel protein structure transmembrane proteins CFTR is a member of the ATP-binding cassette (ABC) family of proteins [ 1 – 3 ]. As such, CFTR has the standard four-domain structure consisting of two transmembrane domains and two soluble nucleotide-binding...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 790–795.
Published: 09 June 2016
... B. Tate C. Vogel H. Overcoming barriers to membrane protein structure determination Nat. Biotechnol. 2011 29 335 340 10.1038/nbt.1833 21478852 4 Overington J. Al-Lazikani B. Hopkins A. Opinion–How many drug targets are there? Nat. Rev. Drug Dis. 2006 5 993...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 88–93.
Published: 09 February 2016
... (O-GlcNAc) O-linked N -acetylglucosamine (O-GlcNAc) transferase post-translational modification protein structure signal transduction Protein O-linked N -acetylglucosamine (O-GlcNAc) post-translational modification is characterized by the attachment of N -acetylglucosamine moieties...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 1033–1040.
Published: 09 October 2015
... the Creative Commons Attribution Licence 3.0 . ATP-binding cassette (ABC) transporter disease multi-drug resistance protein structure transport mechanism 1 Correspondence may be addressed to either author (email [email protected] or [email protected]...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 807–811.
Published: 09 October 2015
...; published by Portland Press Limited 2015 bioinformatics protein structure proteome scoring function tandem repeats Table 1 Scores used to assess TR MSAs Gaps are considered as twenty-first amino acids. Given an MSA of n repeat units, of length l , a fractional frequency can...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1704–1708.
Published: 17 November 2014
... the ability to bind a protein can result from very subtle sequence changes. 1 email [email protected] 4 8 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 antibodies complementarity determining regions evolution moonlighting protein structure...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 479–484.
Published: 20 March 2014
... activation metalloenzyme protein structure Figure 3 Structural and electrostatic comparison of the E. coli and C. butylicum Glo1 enzymes Interface separating surface (green) between the closest approaching residues of the two subunits (red and blue) for ( A ) E. coli Glo1 and ( B ) C...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (6): 1295–1301.
Published: 21 November 2012
... in similar conditions close to their physiological environment, providing information about the protein internal motions and interactions in solution. extracellular electron transfer Geobacter sulfurreducens multihaem cytochrome nuclear magnetic resonance (NMR) protein structure The first...
Includes: Supplementary data
Articles
Sungsam Gong, Catherine L. Worth, G. Richard J. Bickerton, Semin Lee, Duangrudee Tanramluk, Tom L. Blundell
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 727–733.
Published: 22 July 2009
..., distribution and reproduction in any medium, provided the original work is properly cited. buried residue hydrogen bond local structural environment protein evolution protein structure The mechanism and nature of protein–nucleic acid recognition is believed to be different from those of protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 723–726.
Published: 22 July 2009
... protein structure In the 150 years since On the Origin of Species [ 1 ] was published, we have learnt much about that “mystery of mysteries”: how species originate and evolve. Much of the knowledge has come from huge advances in molecular biology which have revealed the constituent molecules...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (2): 157–166.
Published: 20 March 2008
... protein structure The Notch pathway is a transmembrane signal transduction pathway used in cell-fate determination in metazoan development, homoeostasis and stem-cell maintenance and differentiation. Through Notch signalling, neighbouring cells determine each other's fates, producing complex...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 431–434.
Published: 22 May 2006
... Society 2006 docking heparan sulphate heparin protein structure protein surface simulated annealing The complex glycosaminoglycan HS (heparan sulphate) [ 1 ] is found on cell surfaces and in the extracellular matrix in most animal tissues. Many secreted proteins bind...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 742–745.
Published: 26 October 2004
... to date. The implications of this model for the possible mechanisms of antibody-mediated inhibition of EGFR are discussed. ErbB receptor extracellular domain growth factor mechanism-based inhibitor protein structure target-specific drug Recent structural data have led to the proposal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 631–633.
Published: 01 June 2003
...B.A. Wallace; Robert W. Janes CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 601–606.
Published: 01 August 2001
... © 2001 Biochemical Society 2001 amyloid-β peptide α-helix → β-strand transition prion protein protein structure secondary structure prediction Aβ, amyloid-β ES, electrospray PAP, pulmonary alveolar proteinosis PrP, prion protein SP-C, surfactant protein C DPPC...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (2): 264–269.
Published: 01 February 2000
... of the algorithm, it will be possible to compare all of these against the Protein Structure Database and determine the extent to which the current ideal forms can account for the variety of protein structure. Analysis of the remainder should provide a base for the development of further forms. 1 9 1999...