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Keywords: protein-protein interaction
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Articles
Biochem Soc Trans (2024) 52 (6): 2539–2556.
Published: 13 December 2024
... for this article was enabled by the participation of Chinese University of Hong Kong in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JULAC. APP intracellular domain neurodevelopment protein-protein interaction...
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Biochem Soc Trans (2023) 51 (4): 1647–1659.
Published: 30 June 2023
... in mammals. Current knowledge, including genetic analyses of gain- and loss-of-function mutants, highlights the importance of APPs in various physiological functions. Notably, APPs consist of multiple extracellular and intracellular protein-binding regions/domains. Proteinprotein interactions are crucial...
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Biochem Soc Trans (2019) 47 (5): 1393–1404.
Published: 24 September 2019
... in zebrafish and mouse. A number of proteinprotein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed...
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Biochem Soc Trans (2018) 46 (1): 197–206.
Published: 06 February 2018
... has been the realization that a large proportion of proteins have regions with intrinsic disorder [ 56 – 58 ]. The picture to emerge is that protein disorder can play a crucial role in protein function, particularly through its involvement in proteinprotein interactions. Protein folding and protein...
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Biochem Soc Trans (2014) 42 (4): 816–821.
Published: 11 August 2014
... on RAF-induced control of MST2 signalling by proteinprotein interactions. Finally, we recapitulate some of the direct mechanisms, such as ubiquitin-dependent degradation or gene silencing by promoter hypermethylation, involved in MST2 pathway component down-regulation in cancers. 1...
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Biochem Soc Trans (2014) 42 (2): 395–400.
Published: 20 March 2014
... plant hormone, phytosulfokine Science 2002 296 1470 1472 31 Sinz A. Chemical cross-linking and mass spectrometry to map three-dimensional protein structures and proteinprotein interactions Mass Spectrom. Rev. 2006 25 663 682 32 Yamaguchi Y. Pearce G. Ryan C.A...
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Biochem Soc Trans (2014) 42 (1): 130–138.
Published: 23 January 2014
... cellular development and differentiation [ 3 ], but when deregulated are significant mediators of tumorigenesis in various cancers [ 4 , 5 ]. Ets proteins are subclassified by the presence of further domains associated with PPIs (proteinprotein interactions) or transcriptional regulation [ 2 , 3...
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Biochem Soc Trans (2013) 41 (5): 1166–1169.
Published: 23 September 2013
...Oz Sharabi; Jason Shirian; Julia M. Shifman Manipulations of PPIs (proteinprotein interactions) are important for many biological applications such as synthetic biology and drug design. Combinatorial methods have been traditionally used for such manipulations, failing, however, to explain...
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Biochem Soc Trans (2013) 41 (5): 1131–1136.
Published: 23 September 2013
...Nicholas Sawyer; Elizabeth B. Speltz; Lynne Regan Protein engineering is at an exciting stage because designed proteinprotein interactions are being used in many applications. For instance, three designed proteins are now in clinical trials. Although there have been many successes over the last...
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Biochem Soc Trans (2012) 40 (5): 995–999.
Published: 19 September 2012
... 2012 Calvin cycle CP12 intrinsically disordered protein proteinprotein interaction For many years, it had been thought that the ability of a protein to fulfil its cellular function depends on a well-defined three-dimensional structure. In the last decade, however, evidence has...
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Biochem Soc Trans (2012) 40 (4): 624–628.
Published: 20 July 2012
...–protein interaction One of the challenges of nanopore-based protein sensing is clogging of protein inside the pore and absorption of protein on the nanopore wall. Mayer and colleagues addressed this problem by introducing the ‘fluid-wall technology’, originally inspired by olfactory processes...
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Biochem Soc Trans (2012) 40 (3): 523–530.
Published: 22 May 2012
... study, AUC (analytical ultracentrifugation) was repeated in the absence of sucrose, which can perturb proteinprotein interactions, to show again that an equimolar mixture of α 2 and β 2 sedimented at around 10 S with an apparent molecular mass that is consistent with an α 2 β 2 oligomerization state...
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Biochem Soc Trans (2011) 39 (2): 584–588.
Published: 22 March 2011
...–protein interaction recognition sequence restriction enzyme Type II restriction endonucleases recognize specific DNA sequences, typically 4–8 bp long, and cleave both stands at fixed positions relative to the sequence, in reactions that usually require Mg 2+ ions as a cofactor [ 1...
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Biochem Soc Trans (2011) 39 (1): 163–168.
Published: 19 January 2011
... Biochemical Society 2011 archaeon chromosome replication DNA replication proteinprotein interaction replication machinery replisome In all forms of cellular life, chromosomal DNA replication requires the complex interplay of a large number of essential and non-essential protein factors...
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Biochem Soc Trans (2010) 38 (6): 1432–1435.
Published: 24 November 2010
... (MLIV) mucolipin proteinprotein interaction transient receptor potential mucolipin (TRPML) MLIV (mucolipidosis type IV, MIM#252650) is an LSD (lysosomal storage disorder) presenting unique features in the LSD group either in the clinical picture or the nature of the basic metabolic defect...
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Biochem Soc Trans (2010) 38 (6): 1632–1637.
Published: 24 November 2010
... The Authors Journal compilation © 2010 Biochemical Society 2010 mRNA stability phosphorylation proteinprotein interaction translation tristetraprolin (TTP) yeast two-hybrid screen Figure 1 Schematic representation of phosphorylation-dependent regulation of TTP function For details, see...
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Biochem Soc Trans (2010) 38 (4): 947–951.
Published: 26 July 2010
...Vadim B. Vasilyev The first detailed report of a specific interaction of CP (caeruloplasmin) with another protein described its complex with LF (lactoferrin) in 2000. Since then, several proteinprotein interactions involving CP have been reported, mostly concerning iron-containing proteins. The CP...
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Biochem Soc Trans (2010) 38 (2): 388–394.
Published: 22 March 2010
..., control proteinprotein interactions, which in turn determine whether recombination proceeds. The present review brings together the evidence for this model derived from the studies on φC31 integrase, Bxb1 integrase and other related proteins. 1 To whom correspondence should be addressed (email...
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Biochem Soc Trans (2009) 37 (4): 768–771.
Published: 22 July 2009
... interaction datasets can be used to study functional evolution directly. In terms of constraining change, the co-evolution of interacting molecules is a very subtle process. This has implications for the signal being used to predict proteinprotein interactions. In terms of functional change, the ‘rewiring...
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Biochem Soc Trans (2008) 36 (6): 1442–1447.
Published: 19 November 2008
... by using CANDI to confer specificity as well as stability on the resulting proteinprotein interaction, such that the energy barrier between desired and non-desired species is maximized. We have additionally dissected the free energy of the folding pathway of Jun–Fos variants to glean new rules...
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Biochem Soc Trans (2008) 36 (6): 1422–1426.
Published: 19 November 2008
... Biochemical Society 2008 fast kinetics iron acquisition proteinprotein interaction thermodynamics transferrin transferrin receptor 1 Iron is an essential trace element for almost all life forms. It is involved in oxygen transport, key metabolic reactions, DNA synthesis, etc. Iron is also...
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Biochem Soc Trans (2008) 36 (6): 1414–1417.
Published: 19 November 2008
...Ishu Saraogi; Andrew D. Hamilton The inhibition of proteinprotein interactions using small molecules is a viable approach for the treatment of a range of pathological conditions that result from a malfunctioning of these interactions. Our strategy for the design of such agents involves the mimicry...
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Biochem Soc Trans (2007) 35 (6): 1634–1637.
Published: 23 November 2007
...-binding complex initiation factor mRNA post-translational modification proteinprotein interaction translation regulation Gene expression can be regulated at numerous levels from alterations in the chromatin state of the gene through to transcription of DNA, processing and translation...
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Biochem Soc Trans (2007) 35 (6): 1389–1392.
Published: 23 November 2007
... be addressed (email [email protected] ). 2 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 histone deacetylase (HDAC) proteinprotein interaction small ubiquitin-related modifier (SUMO) transcriptional activation transcriptional repression Given...
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Biochem Soc Trans (2007) 35 (5): 962–965.
Published: 25 October 2007
... protein synthesis protein in situ array proteinprotein interaction protein–ribosome–mRNA complex (PRM complex) proteomic technology ribosome display Protein interactions play a critical role in the control of all biological pathways [ 1 ], and their study has therefore become a key area...
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Biochem Soc Trans (2007) 35 (5): 970–973.
Published: 25 October 2007
.... The underlying luminal proteinprotein interactions, however, are inherently difficult to analyse, mainly due to their transient nature and the rather specialized environment of the ER. To overcome these limitations, we developed a PCA (protein fragment complementation assay) based on the citrine variant of YFP...
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Biochem Soc Trans (2007) 35 (5): 835–847.
Published: 25 October 2007
... Journal compilation © 2007 Biochemical Society 2007 membrane protein membrane transport molecular chaperone proteinprotein interaction protein targeting twin-arginine translocase In principle, all protein-targeting systems must rely on an amino acid ‘signaL' displayed by the passenger...
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Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
..., M.B., Lim, E.M.L., Thomas, W.G. and Eidne, K.A. Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells, pp. 1664–1670, © 2006, with permission from Elsevier. A number of studies have now utilized BRET to investigate...
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Biochem Soc Trans (2007) 35 (3): 502–507.
Published: 22 May 2007
... degradosome membrane molecular recognition proteinprotein interaction self-assembly Nearly 50 years ago, Anfisen and colleagues demonstrated that a denatured protein can reform into its native structure spontaneously. These observations were insightfully interpreted as indicating that the amino...
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Biochem Soc Trans (2007) 35 (3): 551–554.
Published: 22 May 2007
... against both wild-type and mutated proteases. They are therefore promising alternatives to active-site-directed inhibitors in AIDS therapy. Disruption of proteinprotein interactions by small molecules is a new way to obtain potentially therapeutic molecules. The actions of dimerization inhibitors...
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Biochem Soc Trans (2006) 34 (2): 317–319.
Published: 20 March 2006
...’ are being discovered [ 2 ]. DNA-binding protein inhibitor DNA mimicry MfpA ocr proteinprotein interaction uracil glycosylase © 2006 The Biochemical Society 2006 12 10 2005 2 Present address: The Sheffield Bioincubator, University of Sheffield, Sheffield S3 7QB, U.K. ...
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Biochem Soc Trans (2006) 34 (1): 162–164.
Published: 20 January 2006
... conformational change NifL–NifA system nitrogen fixation proteinprotein interaction redox regulation Expression of nif genes required for nitrogen fixation in Azotobacter vinelandii is controlled at the transcriptional level by a regulatory system comprising the σ 54 -dependent activator, NifA...
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Biochem Soc Trans (2005) 33 (1): 105–107.
Published: 01 February 2005
... [email protected] ). 30 9 2004 © 2005 The Biochemical Society 2005 molecular chaperone [NiFe] hydrogenase proteinprotein interaction Tat protein transport system N -oxide reductase twin-arginine signal peptide Escherichia coli displays a remarkable flexibility in its...
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Biochem Soc Trans (2004) 32 (6): 1103–1106.
Published: 26 October 2004
... fusion protein. The findings from initial experiments suggest an increase in transcription initiation and elongation rates by AR-AF1–Lex. The role of proteinprotein interactions involving co-activators and basal transcription factors and AR-AF1 activity are discussed. 1 To whom correspondence...
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Biochem Soc Trans (2002) 30 (4): 373–378.
Published: 01 August 2002
...M. R. Roberts; G. L. de Bruxelles 14-3-3 proteins regulate a wide range of target proteins via direct protein-protein interactions. The target-binding domain in 14-3-3 proteins is highly conserved, suggesting similar biochemical properties for all 14-3-3s. However, higher eukaryotes possess...
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Biochem Soc Trans (2002) 30 (2): 47–51.
Published: 01 April 2002
..., pyruvate decarboxylase E2p, dihydrolipoyl acetyltransferase E2o, dihydrolipoyl succinyltransferase E3, dihydrolipoyl dehydrogenase PDH, pyruvate dehydrogenase T 2 , transverse relaxation time lipoic acid lipoyl domain protein-protein interaction pyruvate dehydrogenase Metabolite...
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Biochem Soc Trans (2000) 28 (6): 615–616.
Published: 01 December 2000
... interacted with ACP in the yeast nucleus. 1 To whom correspondence should be addressed (e-mail [email protected] ) 3 7 2000 © 2000 Biochemical Society 2000 enoyl-ACP reductase protein-protein interaction yeast two hybrid ACP, acyl carrier protein DES, stearoyl-ACP...