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Keywords: protein-protein interaction
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2539–2556.
Published: 13 December 2024
... for this article was enabled by the participation of Chinese University of Hong Kong in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JULAC. APP intracellular domain neurodevelopment protein-protein interaction...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1647–1659.
Published: 30 June 2023
... in mammals. Current knowledge, including genetic analyses of gain- and loss-of-function mutants, highlights the importance of APPs in various physiological functions. Notably, APPs consist of multiple extracellular and intracellular protein-binding regions/domains. Protein–protein interactions are crucial...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (5): 1393–1404.
Published: 24 September 2019
... in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (1): 197–206.
Published: 06 February 2018
... has been the realization that a large proportion of proteins have regions with intrinsic disorder [ 56 – 58 ]. The picture to emerge is that protein disorder can play a crucial role in protein function, particularly through its involvement in protein–protein interactions. Protein folding and protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 816–821.
Published: 11 August 2014
... on RAF-induced control of MST2 signalling by protein–protein interactions. Finally, we recapitulate some of the direct mechanisms, such as ubiquitin-dependent degradation or gene silencing by promoter hypermethylation, involved in MST2 pathway component down-regulation in cancers. 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 395–400.
Published: 20 March 2014
... plant hormone, phytosulfokine Science 2002 296 1470 1472 31 Sinz A. Chemical cross-linking and mass spectrometry to map three-dimensional protein structures and protein–protein interactions Mass Spectrom. Rev. 2006 25 663 682 32 Yamaguchi Y. Pearce G. Ryan C.A...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 130–138.
Published: 23 January 2014
... cellular development and differentiation [ 3 ], but when deregulated are significant mediators of tumorigenesis in various cancers [ 4 , 5 ]. Ets proteins are subclassified by the presence of further domains associated with PPIs (protein–protein interactions) or transcriptional regulation [ 2 , 3...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1166–1169.
Published: 23 September 2013
...Oz Sharabi; Jason Shirian; Julia M. Shifman Manipulations of PPIs (protein–protein interactions) are important for many biological applications such as synthetic biology and drug design. Combinatorial methods have been traditionally used for such manipulations, failing, however, to explain...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1131–1136.
Published: 23 September 2013
...Nicholas Sawyer; Elizabeth B. Speltz; Lynne Regan Protein engineering is at an exciting stage because designed protein–protein interactions are being used in many applications. For instance, three designed proteins are now in clinical trials. Although there have been many successes over the last...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 995–999.
Published: 19 September 2012
... 2012 Calvin cycle CP12 intrinsically disordered protein protein–protein interaction For many years, it had been thought that the ability of a protein to fulfil its cellular function depends on a well-defined three-dimensional structure. In the last decade, however, evidence has...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 624–628.
Published: 20 July 2012
...–protein interaction One of the challenges of nanopore-based protein sensing is clogging of protein inside the pore and absorption of protein on the nanopore wall. Mayer and colleagues addressed this problem by introducing the ‘fluid-wall technology’, originally inspired by olfactory processes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (3): 523–530.
Published: 22 May 2012
... study, AUC (analytical ultracentrifugation) was repeated in the absence of sucrose, which can perturb protein–protein interactions, to show again that an equimolar mixture of α 2 and β 2 sedimented at around 10 S with an apparent molecular mass that is consistent with an α 2 β 2 oligomerization state...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 124–128.
Published: 19 January 2012
... that functionally compensate for loss of their counterparts in Drosophila . Furthermore, studies in Drosophila and mammalian cell systems showed that Hippo signalling represents a kinase cascade that is tightly regulated by PPIs (protein–protein interactions). Several Hippo signalling molecules contain SARAH...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1327–1333.
Published: 21 September 2011
...Noha Abdel-Rahman; Alfonso Martinez-Arias; Tom L. Blundell In order to achieve greater selectivity in drug discovery, researchers in both academia and industry are targeting cell regulatory systems. This often involves targeting the protein–protein interactions of regulatory multiprotein assemblies...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 584–588.
Published: 22 March 2011
...–protein interaction recognition sequence restriction enzyme Type II restriction endonucleases recognize specific DNA sequences, typically 4–8 bp long, and cleave both stands at fixed positions relative to the sequence, in reactions that usually require Mg 2+ ions as a cofactor [ 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 163–168.
Published: 19 January 2011
... Biochemical Society 2011 archaeon chromosome replication DNA replication protein–protein interaction replication machinery replisome In all forms of cellular life, chromosomal DNA replication requires the complex interplay of a large number of essential and non-essential protein factors...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1432–1435.
Published: 24 November 2010
... (MLIV) mucolipin protein–protein interaction transient receptor potential mucolipin (TRPML) MLIV (mucolipidosis type IV, MIM#252650) is an LSD (lysosomal storage disorder) presenting unique features in the LSD group either in the clinical picture or the nature of the basic metabolic defect...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1632–1637.
Published: 24 November 2010
... The Authors Journal compilation © 2010 Biochemical Society 2010 mRNA stability phosphorylation protein–protein interaction translation tristetraprolin (TTP) yeast two-hybrid screen Figure 1 Schematic representation of phosphorylation-dependent regulation of TTP function For details, see...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 947–951.
Published: 26 July 2010
...Vadim B. Vasilyev The first detailed report of a specific interaction of CP (caeruloplasmin) with another protein described its complex with LF (lactoferrin) in 2000. Since then, several protein–protein interactions involving CP have been reported, mostly concerning iron-containing proteins. The CP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 923–927.
Published: 26 July 2010
[email protected] ). 10 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 blue native gel electrophoresis high-throughput screen Pearson correlation protein–protein interaction Proteomic Complex Detection using Sedimentation (ProCoDeS) tandem affinity purification (TAP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 901–907.
Published: 26 July 2010
... large dynamic range (dissociation constants from 10 −12 M to 10 −1 M). In the present paper, we review some of the advances that have been made in the two different types of sedimentation experiment – sedimentation equilibrium and sedimentation velocity – for the analysis of protein–protein interactions...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 940–946.
Published: 26 July 2010
...Parvez I. Haris For most biophysical techniques, characterization of protein–protein interactions is challenging; this is especially true with methods that rely on a physical phenomenon that is common to both of the interacting proteins. Thus, for example, in IR spectroscopy, the carbonyl vibration...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 388–394.
Published: 22 March 2010
..., control protein–protein interactions, which in turn determine whether recombination proceeds. The present review brings together the evidence for this model derived from the studies on φC31 integrase, Bxb1 integrase and other related proteins. 1 To whom correspondence should be addressed (email...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 768–771.
Published: 22 July 2009
... interaction datasets can be used to study functional evolution directly. In terms of constraining change, the co-evolution of interacting molecules is a very subtle process. This has implications for the signal being used to predict protein–protein interactions. In terms of functional change, the ‘rewiring...
Articles
Bostjan Kobe, Gregor Guncar, Rebecca Buchholz, Thomas Huber, Bohumil Maco, Nathan Cowieson, Jennifer L. Martin, Mary Marfori, Jade K. Forwood
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1438–1441.
Published: 19 November 2008
... structural information on protein–protein complexes, and it yields the most detailed structural information about the interaction. However, there is a major issue when using MX to study protein–protein interactions: a crystal structure does not define a unique protein–protein interface. A crystal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1442–1447.
Published: 19 November 2008
... by using CANDI to confer specificity as well as stability on the resulting protein–protein interaction, such that the energy barrier between desired and non-desired species is maximized. We have additionally dissected the free energy of the folding pathway of Jun–Fos variants to glean new rules...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1422–1426.
Published: 19 November 2008
... Biochemical Society 2008 fast kinetics iron acquisition protein–protein interaction thermodynamics transferrin transferrin receptor 1 Iron is an essential trace element for almost all life forms. It is involved in oxygen transport, key metabolic reactions, DNA synthesis, etc. Iron is also...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1414–1417.
Published: 19 November 2008
...Ishu Saraogi; Andrew D. Hamilton The inhibition of protein–protein interactions using small molecules is a viable approach for the treatment of a range of pathological conditions that result from a malfunctioning of these interactions. Our strategy for the design of such agents involves the mimicry...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 479–482.
Published: 21 May 2008
... addition to techniques for the investigation of protein–protein interactions in this model organism. 1 To whom correspondence should be addressed (email [email protected] ). 28 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 The systems described comprise...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (2): 157–166.
Published: 20 March 2008
... cleavages release NICD in the receiving cell, providing access to the nucleus and complex formation with CSL (see the text for details). ADAM, a disintegrin and metalloproteinase; E(spl) , Enhancer of split . ankyrin repeat intrinsic disorder Notch signalling protein–protein interaction...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1634–1637.
Published: 23 November 2007
...-binding complex initiation factor mRNA post-translational modification protein–protein interaction translation regulation Gene expression can be regulated at numerous levels from alterations in the chromatin state of the gene through to transcription of DNA, processing and translation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1389–1392.
Published: 23 November 2007
... be addressed (email [email protected] ). 2 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 histone deacetylase (HDAC) protein–protein interaction small ubiquitin-related modifier (SUMO) transcriptional activation transcriptional repression Given...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 962–965.
Published: 25 October 2007
... protein synthesis protein in situ array protein–protein interaction protein–ribosome–mRNA complex (PRM complex) proteomic technology ribosome display Protein interactions play a critical role in the control of all biological pathways [ 1 ], and their study has therefore become a key area...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1021–1026.
Published: 25 October 2007
... selective competitive inhibitor peptides and allosteric agonist peptides of individual PKC isoenzymes. The strategies and rationale used to identify these peptide regulators of protein–protein interaction may be applicable to other signalling events. Importantly, the PKC-regulating peptides proved...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 966–969.
Published: 25 October 2007
...S. Rotem; C. Katz; A. Friedler ASPP (apoptosis-stimulating protein of p53) 2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. Here, we provide an overview of the structure and protein–protein interactions of ASPP2. The C-terminus of ASPP2 contains Ank (ankyrin...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 970–973.
Published: 25 October 2007
.... The underlying luminal protein–protein interactions, however, are inherently difficult to analyse, mainly due to their transient nature and the rather specialized environment of the ER. To overcome these limitations, we developed a PCA (protein fragment complementation assay) based on the citrine variant of YFP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 835–847.
Published: 25 October 2007
... Journal compilation © 2007 Biochemical Society 2007 membrane protein membrane transport molecular chaperone protein–protein interaction protein targeting twin-arginine translocase In principle, all protein-targeting systems must rely on an amino acid ‘signaL' displayed by the passenger...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
..., M.B., Lim, E.M.L., Thomas, W.G. and Eidne, K.A. Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells, pp. 1664–1670, © 2006, with permission from Elsevier. A number of studies have now utilized BRET to investigate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 502–507.
Published: 22 May 2007
... degradosome membrane molecular recognition protein–protein interaction self-assembly Nearly 50 years ago, Anfisen and colleagues demonstrated that a denatured protein can reform into its native structure spontaneously. These observations were insightfully interpreted as indicating that the amino...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 551–554.
Published: 22 May 2007
... against both wild-type and mutated proteases. They are therefore promising alternatives to active-site-directed inhibitors in AIDS therapy. Disruption of protein–protein interactions by small molecules is a new way to obtain potentially therapeutic molecules. The actions of dimerization inhibitors...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 679–682.
Published: 25 October 2006
.... Until recently, all protein interactions had to be determined in vitro using biochemical approaches: this biochemical legacy has provided cell biologists with the basis to test defined protein–protein interactions not only inside cells, but now also with high spatial resolution. These techniques can...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 971–974.
Published: 25 October 2006
... The Biochemical Society 2006 folded protein guanine nucleotide dissociation inhibitor (GDI) Rho GTPase protein–protein interaction talin vinculin There are now many examples of ‘intrinsically disordered’ proteins [ 1 , 2 ], including proteins involved in cell-cycle regulation, signal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1054–1057.
Published: 25 October 2006
... the events of transactivation, the AR makes specific protein–protein interactions with several basal transcription factors such as TBP (TATA-box-binding protein) and TFIIF (transcription factor IIF). These interactions occur predominantly within a defined region termed AF1 (activation function-1) located...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (2): 317–319.
Published: 20 March 2006
...’ are being discovered [ 2 ]. DNA-binding protein inhibitor DNA mimicry MfpA ocr protein–protein interaction uracil glycosylase © 2006 The Biochemical Society 2006 12 10 2005 2 Present address: The Sheffield Bioincubator, University of Sheffield, Sheffield S3 7QB, U.K. ...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 162–164.
Published: 20 January 2006
... conformational change NifL–NifA system nitrogen fixation protein–protein interaction redox regulation Expression of nif genes required for nitrogen fixation in Azotobacter vinelandii is controlled at the transcriptional level by a regulatory system comprising the σ 54 -dependent activator, NifA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 105–107.
Published: 01 February 2005
... [email protected] ). 30 9 2004 © 2005 The Biochemical Society 2005 molecular chaperone [NiFe] hydrogenase protein–protein interaction Tat protein transport system N -oxide reductase twin-arginine signal peptide Escherichia coli displays a remarkable flexibility in its...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1103–1106.
Published: 26 October 2004
... fusion protein. The findings from initial experiments suggest an increase in transcription initiation and elongation rates by AR-AF1–Lex. The role of protein–protein interactions involving co-activators and basal transcription factors and AR-AF1 activity are discussed. 1 To whom correspondence...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (4): 373–378.
Published: 01 August 2002
...M. R. Roberts; G. L. de Bruxelles 14-3-3 proteins regulate a wide range of target proteins via direct protein-protein interactions. The target-binding domain in 14-3-3 proteins is highly conserved, suggesting similar biochemical properties for all 14-3-3s. However, higher eukaryotes possess...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (2): 47–51.
Published: 01 April 2002
..., pyruvate decarboxylase E2p, dihydrolipoyl acetyltransferase E2o, dihydrolipoyl succinyltransferase E3, dihydrolipoyl dehydrogenase PDH, pyruvate dehydrogenase T 2 , transverse relaxation time lipoic acid lipoyl domain protein-protein interaction pyruvate dehydrogenase Metabolite...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (6): 615–616.
Published: 01 December 2000
... interacted with ACP in the yeast nucleus. 1 To whom correspondence should be addressed (e-mail [email protected] ) 3 7 2000 © 2000 Biochemical Society 2000 enoyl-ACP reductase protein-protein interaction yeast two hybrid ACP, acyl carrier protein DES, stearoyl-ACP...