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Keywords: proteinase
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Articles

A copper-binding site in the cytoplasmic domain of BACE1 identifies a possible link to metal homoeostasis and oxidative stress in Alzheimer's disease

C. Dingwall
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 571–573.
https://doi.org/10.1042/BST0350571
Published: 22 May 2007
...C. Dingwall The amyloidogenic processing pathway of the APP (amyloid precursor protein) generates Aβ (amyloid β-peptide), the major constituent in Alzheimer's disease senile plaques. This processing is catalysed by two unusual membrane-localized aspartic proteinases, β-secretase [BACE1 (β-site APP...
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Articles

Molecular mousetraps and the serpinopathies

D.A. Lomas, D. Belorgey, M. Mallya, E. Miranda, K.J. Kinghorn, L.K. Sharp, R.L. Phillips, R. Page, A.S. Robertson, D.C. Crowther
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (2): 321–330.
https://doi.org/10.1042/BST0330321
Published: 01 April 2005
...D.A. Lomas; D. Belorgey; M. Mallya; E. Miranda; K.J. Kinghorn; L.K. Sharp; R.L. Phillips; R. Page; A.S. Robertson; D.C. Crowther Members of the serine proteinase inhibitor or serpin superfamily inhibit their target proteinases by a remarkable conformational transition that involves the enzyme being...
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