...Yannic Becker; Hermann Haller Heparan sulfate (HS) proteoglycans are life-supporting proteins comprising a core protein to which one or more HS glycan chains are covalently bound. HS proteoglycans act as binding sites for circulating cells and molecules, allow gradient formation, and provide local...

...Sylvie Ricard-Blum; John R. Couchman Syndecans are transmembrane heparan sulfate proteoglycans present on most mammalian cell surfaces. They have a long evolutionary history, a single syndecan gene being expressed in bilaterian invertebrates. Syndecans have attracted interest because...

... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 antibiotics infection malaria proteoglycan Glycans represent one of the most diverse classes of biological macromolecules. They are a major part of the biomass of every organism...

..., heterogeneous polysaccharides displayed on proteoglycans that bind various ligands, including cell surface proteins expressed on Leishmania promastigote and amastigote parasites. The fine chemical structure of HS is formed by a plethora of specific enzymes during biosynthesis, with various positions (N-, 2-O...

...Rafael S. Aquino; Yvonne Hui-Fang Teng; Pyong Woo Park Syndecan-1 (Sdc1) is a major cell surface heparan sulfate (HS) proteoglycan of epithelial cells, a cell type targeted by many bacterial pathogens early in their pathogenesis. Loss of Sdc1 in mice is a gain-of-function mutation...

... hyaluronic acid mechanosignaling proteoglycan Other studies indicate that integrins can co-operate with BMPRs in an ECM-dependent manner, which augments BMP signaling. For example, the binding of the drosophila BMP2/4 homolog Decapentaplegic (Dpp) or human BMP4 to collagen type IV promotes BMP...

...A.E.I. Proudfoot Chemokines exert their biological activity through high-affinity interactions with cell-surface receptors, thereby activating specific signalling pathways, and a second low-affinity interaction with proteoglycans. Proteoglycans consist of a protein core, to which GAG...

...B. Mulloy; C.C. Rider The defining characteristic of the glycoproteins known as proteoglycans is the presence of O-linked acidic polysaccharides known as GAGs (glycosaminoglycans). The backbone of these linear polysaccharides is a repeating disaccharide, comprising N -acetyl hexosamine alternating...

...S.E. Stringer The presence of HS (heparan sulphate) proteoglycans on the cell surface and in the extracellular environment is critical to many physiological processes including the growth of new blood vessels from pre-existing vasculature (angiogenesis). A plethora of growth factors...

... 2003 glucosaminyl N-deacetylase/N-sulphotransferase heparan sulphate heparan sulphate biosynthesis knockout mice proteoglycan Abbreviations used: HS, heparan sulphate; NDST, glucosaminyl N-deacetylase/N-sulphotransferase. 340 Biochemical Society Transactions (2003) Volume 31...

... 22 November 2002 Copyright 2003 Biochemical Society 2003 cancer dermatan sulphate glycosaminoglycan heparan sulphate hepatocyte growth factor/scatter factor proteoglycan Abbreviations used: DS; dermatan sulphate; GAG; glycosaminoglycan; HGF; hepatocyte growth factor; HS...

... and innervated with degeneration and disease. This may lead to an increased supply of oxygen and nutrients to the disc, but can also introduce other cells types and molecules such as cytokines and growth factors. collagen innervation intervertebral disc proteoglycan vascularization Biochemical Society...

... heparanome proteoglycan sulphotransferase HS, heparan sulphate HSPG, HS proteoglycan FGF, fibroblast growth factor FGFR, FGF receptor NDST, N-deacetylase-N-sulphotransferase 6OST, 6-O-sulphotransferase 2OST, 2-O-sulphotransferase The Glycobiology of Development Dynamic biosynthesis...

...T. M. Rogalski; G. P. Mullen; J. A. Bush; E. J. Gilchrist; D. G. Moerman The unc-52 gene encodes the nematode homologue of mammalian perlecan, the major heparan sulphate proteoglycan of the extracellular matrix. This is a large complex protein with regions similar to low-density lipoprotein...