... ubiquitin ligases. Systems that are available or being developed in plants can be distinguished primarily by the type of E3 ubiquitin ligase involved, including those that utilize Cullin-RING ligases, bacterial novel E3 ligases, and N-end rule pathway E3 ligases, or they can be controlled by proteolysis...

... protein quality control proteolysis SPFH protein Taken together, HflKC assembly regulates FtsH proteolytic activity via the membrane compartmentalization effect. However, the exact mechanism of HflKC as either a negative regulator of non-substrate membrane proteins by isolating them from FtsH...

.... The activity of the LDLR is also regulated by proteolysis. Proteolytic cleavage of the transmembrane region of the LDLR by γ-secretase destabilises the receptor, directing it to the lysosome for degradation. Shedding of the extracellular domain of the receptor by membrane-type 1 matrix metalloprotease...

... via intra-mitochondrial proteolysis involving multiple AAA+ proteases. Together, these proteolytic pathways maintain the activity and homeostasis of OXPHOS components. Correspondence: Monika W. Murcha ( [email protected] ) 9 2 2022 7 4 2022 3 5 2022 © 2022...

... extracellular matrix fibrosis heat shock proteins molecular chaperones proteolysis Fibronectin is an abundant non-collagenase ECM protein. FN is secreted as a soluble dimer composed of two identical monomers of ∼240 kDa joined via C-terminal disulfide bonds. FN interacts with multiple ECM components...

... by the participation of University of Western Australia in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. peptides plant proteins protein structure proteolysis Asparaginyl endopeptidases (AEPs) are cysteine...

...Yipeng Wang; Sarika Garg; Eva-Maria Mandelkow; Eckhard Mandelkow Tau aggregation is a hallmark of several neurodegenerative diseases, including AD (Alzheimer's disease), although the mechanism underlying tau aggregation remains unclear. Recent studies show that the proteolysis of tau plays...

... , of which Asp 421 is the preferred cleavage site, as is evident from mutagenesis [ 5 , 26 ]. The consensus sequence at Asp 421 is recognized by caspase 3 and caspase 7 and mutation of this residue to glutamate inhibits caspase-mediated tau proteolysis [ 27 ]. Transfection of cells with the fragment of tau...

... stimulates a programme of tyrosine phosphorylation, ubiquitination and proteolysis. This is linked to ESCRT (endosomal sorting complex required for transport)-mediated recognition of activated VEGFR2 and sorting in endosomes before arrival in lysosomes for terminal degradation. In addition, Rab GTPases...

...Gemma Marfany; Rosa Farràs; Eduardo Salido; Dimitris P. Xirodimas; Manuel S. Rodríguez Proteolysis has traditionally been considered as a radical way to terminate the function of a protein. However, protein destruction also is the starting point for many processes as they can only occur when...

... results in a latent 20S core particle that can serve further as a platform for 19S regulatory particle attachment and formation of the biologically active 26S proteasome for ubiquitin-dependent proteolysis. Both general and dedicated proteasome assembly chaperones regulate the efficiency and outcome...

...Catherine Lindon Inactivation of key substrates by ubiquitin-mediated proteolysis controls the passage of cells through mitosis. The APC/C (anaphase-promoting complex/cyclosome) targets a large number of substrates for proteolysis during the final steps of mitosis and cytokinesis...

... to many diseases involving matrix turnover. © The Authors Journal compilation © 2007 Biochemical Society 2007 cytokine extracellular matrix fibrotic disease inflammation matrix turnover proteolysis 1 email [email protected] 9 5 2007 Matrix breakdown...

... The Biochemical Society 2007 aleurone Arabidopsis calpain epidermis proteolysis receptor-like kinase Most plant organs are covered with a well-defined epidermal layer, which is crucial for defence against pathogens, regulation of water relations and gas exchange and, in the root...

... a prerequisite for the octarepeat region in the N-terminus of the protein. Significantly, two disease-associated mutants of PrP, namely PG14 and A116V (Ala 116 →Val), were unable to undergo β-cleavage and this lack of proteolysis was accompanied by functional consequences in cells expressing these mutant...

... To whom correspondence should be addressed (email [email protected] ). 22 3 2004 © 2004 The Biochemical Society 2004 apoptosis eukaryotic initiation factor (eIF) mRNA protein synthesis proteolysis translation inhibition Protein synthesis can be conveniently...

... 2004 Alzheimer's disease amyloidogenesis cholesterol glycosylation lovastatin proteolysis β-secretase Abbreviations used: Aβ, β-amyloid; APP, Alzheimer's amyloid precursor protein; APPswe, Swedish mutant of APP; ASP-2, aspartic protease 2; FCS, fetal calf serum; Endo H...

... and possible exploitation as therapeutic targets. The Behaviour of Enzymes in Cells 723 Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries A.J. Turner1 Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K...

..., protein degradation serves as an important mechanism for acclimation of the Key words: chloroplast, DegP, RsH, proteolysis. Abbreviations used: PS II, photosystem II; RISP, Rieske Fe-S protein. 'To whom correspondence should be addressed (e-mail [email protected]). photosynthetic machinery to changes...

... functions during the biogenesis of mitochondria. Their activity is modulated by another membrane-protein complex that is composed of prohibitins. Peptides generated upon proteolysis in the matrix space are transported across the inner membrane by an ATP-binding cassette transporter. The function...