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Keywords: proteolysis
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Biochem Soc Trans (2024) 52 (1): 431–440.
Published: 08 February 2024
.... The activity of the LDLR is also regulated by proteolysis. Proteolytic cleavage of the transmembrane region of the LDLR by γ-secretase destabilises the receptor, directing it to the lysosome for degradation. Shedding of the extracellular domain of the receptor by membrane-type 1 matrix metalloprotease...
Biochem Soc Trans (2022) 50 (3): 1119–1132.
Published: 19 May 2022
... via intra-mitochondrial proteolysis involving multiple AAA+ proteases. Together, these proteolytic pathways maintain the activity and homeostasis of OXPHOS components. Correspondence: Monika W. Murcha ( monika.murcha@uwa.edu.au ) 9 2 2022 7 4 2022 3 5 2022 © 2022...
Biochem Soc Trans (2021) 49 (6): 2611–2625.
Published: 16 December 2021
... may have therapeutic potential in conditions characterised by ECM dysfunction. © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 extracellular matrix fibrosis heat shock proteins molecular chaperones proteolysis...
Biochem Soc Trans (2021) 49 (2): 965–976.
Published: 05 March 2021
... plants, where they are also sometimes called vacuolar processing enzymes due to their localisation in vacuoles and their role in processing vacuolar proteins [ 1 , 5 ]. peptides plant proteins protein structure proteolysis © 2021 The Author(s) 2021 This is an open access article...
Biochem Soc Trans (2010) 38 (4): 1016–1020.
Published: 26 July 2010
... cleavage site, as is evident from mutagenesis [ 5 , 26 ]. The consensus sequence at Asp 421 is recognized by caspase 3 and caspase 7 and mutation of this residue to glutamate inhibits caspase-mediated tau proteolysis [ 27 ]. Transfection of cells with the fragment of tau corresponding to residues 1–421...
Biochem Soc Trans (2010) 38 (4): 955–961.
Published: 26 July 2010
...Yipeng Wang; Sarika Garg; Eva-Maria Mandelkow; Eckhard Mandelkow Tau aggregation is a hallmark of several neurodegenerative diseases, including AD (Alzheimer's disease), although the mechanism underlying tau aggregation remains unclear. Recent studies show that the proteolysis of tau plays...
Biochem Soc Trans (2008) 36 (5): 807–812.
Published: 19 September 2008
... results in a latent 20S core particle that can serve further as a platform for 19S regulatory particle attachment and formation of the biologically active 26S proteasome for ubiquitin-dependent proteolysis. Both general and dedicated proteasome assembly chaperones regulate the efficiency and outcome...
Biochem Soc Trans (2008) 36 (3): 405–410.
Published: 21 May 2008
...Catherine Lindon Inactivation of key substrates by ubiquitin-mediated proteolysis controls the passage of cells through mitosis. The APC/C (anaphase-promoting complex/cyclosome) targets a large number of substrates for proteolysis during the final steps of mitosis and cytokinesis...
Biochem Soc Trans (2007) 35 (4): 643–646.
Published: 20 July 2007
... and composition in more subtle ways. For instance, proteolysis of tenascin-C releases fragments that inhibit fibroblast migration from this molecule which, when intact, stimulates migration. In this way, proteolysis may limit fibroblast infiltration into a wound bed. Conversely, lack of proteolytic activity...
Biochem Soc Trans (2007) 35 (1): 156–160.
Published: 22 January 2007
... 801 The Arabidopsis genome also contains predicted components of the aspartate protease containing γ secretase complex [ 41 , 46 ] and seven Rhomboid class serine proteases [ 47 ], both of which have been implicated in the intramembrane proteolysis of both membrane-located ligand precursors...
Biochem Soc Trans (2005) 33 (5): 1123–1125.
Published: 26 October 2005
... a prerequisite for the octarepeat region in the N-terminus of the protein. Significantly, two disease-associated mutants of PrP, namely PG14 and A116V (Ala 116 →Val), were unable to undergo β-cleavage and this lack of proteolysis was accompanied by functional consequences in cells expressing these mutant...
Biochem Soc Trans (2004) 32 (4): 606–610.
Published: 01 August 2004
... © 2004 The Biochemical Society 2004 apoptosis eukaryotic initiation factor (eIF) mRNA protein synthesis proteolysis translation inhibition Protein synthesis can be conveniently subdivided into three phases: initiation, elongation and termination. It is now clear...
Biochem Soc Trans (2004) 32 (1): 33–36.
Published: 01 February 2004
... 2004 Alzheimer's disease amyloidogenesis cholesterol glycosylation lovastatin proteolysis β-secretase Abbreviations used: Aβ, β-amyloid; APP, Alzheimer's amyloid precursor protein; APPswe, Swedish mutant of APP; ASP-2, aspartic protease 2; FCS, fetal calf serum; Endo H...
Biochem Soc Trans (2003) 31 (3): 723–727.
Published: 01 June 2003
... and possible exploitation as therapeutic targets. The Behaviour of Enzymes in Cells 723 Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries A.J. Turner1 Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K...
Biochem Soc Trans (2001) 29 (4): 427–430.
Published: 01 August 2001
..., protein degradation serves as an important mechanism for acclimation of the Key words: chloroplast, DegP, RsH, proteolysis. Abbreviations used: PS II, photosystem II; RISP, Rieske Fe-S protein. 'To whom correspondence should be addressed (e-mail zach@agri.huji.ac.il). photosynthetic machinery to changes...
Biochem Soc Trans (2001) 29 (4): 431–436.
Published: 01 August 2001
... functions during the biogenesis of mitochondria. Their activity is modulated by another membrane-protein complex that is composed of prohibitins. Peptides generated upon proteolysis in the matrix space are transported across the inner membrane by an ATP-binding cassette transporter. The function...